PMID- 37012135
OWN - NLM
STAT- MEDLINE
DCOM- 20230911
LR  - 20230911
IS  - 1879-1476 (Electronic)
IS  - 0385-8146 (Linking)
VI  - 50
IP  - 6
DP  - 2023 Dec
TI  - Olfactory dysfunction in Japanese children with moderate-to-severe allergic 
      rhinitis.
PG  - 904-910
LID - S0385-8146(23)00061-5 [pii]
LID - 10.1016/j.anl.2023.03.004 [doi]
AB  - OBJECTIVE: Detailed quantitative studies on olfaction remain inadequate in 
      patients with paediatric allergic rhinitis (AR). This study examined olfactory 
      dysfunction in children with AR. METHODS: From July 2016 to November 2018, 
      children aged 6-9 years were recruited and grouped as AR (n = 30) or without AR 
      (control group, n = 10). Odour identification was evaluated by the Universal 
      Sniff (U-Sniff) test and the Open Essence (OE). The results were compared between 
      the AR and control groups. Intranasal mucosa findings, nasal smear eosinophil 
      counts, blood eosinophil counts, total immunoglobulin E (IgE) levels, Japanese 
      cedar-specific IgE and Dermatophagoides pteronyssinus-specific IgE were evaluated 
      in all participants. Additionally, the presence of sinusitis and adenoid 
      hypertrophy in patients with AR was also evaluated by sinus X-ray examinations. 
      RESULTS: The median U-Sniff test scores were not significantly different between 
      the AR and control groups (9.0 vs. 10.0, respectively; p = 0.107). The OE score 
      was significantly lower in the AR group than in the control group (4.0 vs. 8.0; 
      p = 0.007, respectively), especially in the moderate-to-severe AR group versus 
      the control group (4.0 vs. 8.0; p = 0.004). Furthermore, in the OE, the correct 
      answer rates for 'wood', 'cooking gas' and 'sweaty socks' were significantly 
      lower in the AR group than in the control group. CONCLUSIONS: Paediatric AR 
      patients can reduce olfactory identification ability, and the degree may be 
      associated with the severity of AR in nasal mucosal findings. Furthermore, 
      olfactory dysfunction may slow down the response to 'emergency situations', such 
      as gas leak.
CI  - Copyright (c) 2023. Published by Elsevier B.V.
FAU - Suzuki, Ryohei
AU  - Suzuki R
AD  - Department of Pediatrics, Daisan Hospital, The Jikei University School of 
      Medicine, Tokyo, Japan; Department of Pediatrics, The Jikei University School of 
      Medicine, Tokyo, Japan; Department of Pediatrics, Fuji City General Hospital, 
      Fuji, Japan. Electronic address: ryohei7@jikei.ac.jp.
FAU - Mori, Eri
AU  - Mori E
AD  - Department of Otorhinolaryngology, Daisan Hospital, The Jikei University School 
      of Medicine, Tokyo, Japan; Department of Otorhinolaryngology, The Jikei 
      University School of Medicine, Tokyo, Japan.
FAU - Iwasaki, Hijiriko
AU  - Iwasaki H
AD  - Department of Otorhinolaryngology, Daisan Hospital, The Jikei University School 
      of Medicine, Tokyo, Japan; Department of Otorhinolaryngology, The Jikei 
      University School of Medicine, Tokyo, Japan.
FAU - Shimamura, Yosuke
AU  - Shimamura Y
AD  - Department of Otorhinolaryngology, Daisan Hospital, The Jikei University School 
      of Medicine, Tokyo, Japan; Department of Otorhinolaryngology, The Jikei 
      University School of Medicine, Tokyo, Japan.
FAU - Shigeta, Yasushi
AU  - Shigeta Y
AD  - Department of Otorhinolaryngology, The Jikei University School of Medicine, 
      Tokyo, Japan; Department of Otorhinolaryngology, Fuji City General Hospital, 
      Fuji, Japan.
FAU - Sagara, Nagatoshi
AU  - Sagara N
AD  - Department of Pediatrics, Daisan Hospital, The Jikei University School of 
      Medicine, Tokyo, Japan; Department of Pediatrics, The Jikei University School of 
      Medicine, Tokyo, Japan.
FAU - Aota, Akiko
AU  - Aota A
AD  - Department of Pediatrics, Daisan Hospital, The Jikei University School of 
      Medicine, Tokyo, Japan; Department of Pediatrics, The Jikei University School of 
      Medicine, Tokyo, Japan.
FAU - Akashi, Kenichi
AU  - Akashi K
AD  - Department of Pediatrics, Daisan Hospital, The Jikei University School of 
      Medicine, Tokyo, Japan; Department of Pediatrics, The Jikei University School of 
      Medicine, Tokyo, Japan.
FAU - Toyoda, Keiko
AU  - Toyoda K
AD  - Department of Radiology, Daisan Hospital, The Jikei University School of 
      Medicine, Tokyo, Japan; Department of Radiology, The Jikei University School of 
      Medicine, Tokyo, Japan.
FAU - Katsunuma, Toshio
AU  - Katsunuma T
AD  - Department of Pediatrics, Daisan Hospital, The Jikei University School of 
      Medicine, Tokyo, Japan; Department of Pediatrics, The Jikei University School of 
      Medicine, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20230401
PL  - Netherlands
TA  - Auris Nasus Larynx
JT  - Auris, nasus, larynx
JID - 7708170
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Humans
MH  - Child
MH  - Smell
MH  - *Rhinitis, Allergic/complications
MH  - *Paranasal Sinuses
MH  - Immunoglobulin E
MH  - *Olfaction Disorders
OTO - NOTNLM
OT  - Olfaction disorders
OT  - Olfactory test
OT  - Paediatric rhinology
OT  - Quality of life
OT  - Rhinitis
OT  - Smell
COIS- Declaration of Competing Interest The authors declare no conflict of interest.
EDAT- 2023/04/04 06:00
MHDA- 2023/09/11 06:43
CRDT- 2023/04/03 22:02
PHST- 2022/10/27 00:00 [received]
PHST- 2023/03/06 00:00 [revised]
PHST- 2023/03/10 00:00 [accepted]
PHST- 2023/09/11 06:43 [medline]
PHST- 2023/04/04 06:00 [pubmed]
PHST- 2023/04/03 22:02 [entrez]
AID - S0385-8146(23)00061-5 [pii]
AID - 10.1016/j.anl.2023.03.004 [doi]
PST - ppublish
SO  - Auris Nasus Larynx. 2023 Dec;50(6):904-910. doi: 10.1016/j.anl.2023.03.004. Epub 
      2023 Apr 1.