PMID- 37013673 OWN - NLM STAT- MEDLINE DCOM- 20231216 LR - 20240314 IS - 1522-2586 (Electronic) IS - 1053-1807 (Linking) VI - 59 IP - 1 DP - 2024 Jan TI - Prognostic Value of Left Ventricular Longitudinal Function and Myocardial Fibrosis in Patients With Ischemic and Non-Ischemic Dilated Cardiomyopathy Concomitant With Type 2 Diabetes Mellitus: A 3.0 T Cardiac MR Study. PG - 164-176 LID - 10.1002/jmri.28723 [doi] AB - BACKGROUND: Poorly controlled type 2 diabetes mellitus (T2DM) is known to result in left ventricular (LV) dysfunction, myocardial fibrosis, and ischemic/nonischemic dilated cardiomyopathy (ICM/NIDCM). However, less is known about the prognostic value of T2DM on LV longitudinal function and late gadolinium enhancement (LGE) assessed with cardiac MRI in ICM/NIDCM patients. PURPOSE: To measure LV longitudinal function and myocardial scar in ICM/NIDCM patients with T2DM and to determine their prognostic values. STUDY TYPE: Retrospective cohort. POPULATION: Two hundred thirty-five ICM/NIDCM patients (158 with T2DM and 77 without T2DM). FIELD STRENGTH/SEQUENCE: 3T; steady-state free precession cine; phase-sensitive inversion recovery segmented gradient echo LGE sequences. ASSESSMENT: Global peak longitudinal systolic strain rate (GLPSSR) was evaluated to LV longitudinal function with feature tracking. The predictive value of GLPSSR was determined with ROC curve. Glycated hemoglobin (HbA1c) was measured. The primary adverse cardiovascular endpoint was follow up every 3 months. STATISTICAL TESTS: Mann-Whitney U test or student's t-test; Intra and inter-observer variabilities; Kaplan-Meier method; Cox proportional hazards analysis (threshold = 5%). RESULTS: ICM/NIDCM patients with T2DM exhibited significantly lower absolute value of GLPSSR (0.39 +/- 0.14 vs. 0.49 +/- 0.18) and higher proportion of LGE positive (+) despite similar LV ejection fraction, compared to without T2DM. LV GLPSSR was able to predict primary endpoint (AUC 0.73) and optimal cutoff point was 0.4. ICM/NIDCM patients with T2DM (GLPSSR < 0.4) had more markedly impaired survival. Importantly, this group (GLPSSR < 0.4, HbA1c >/= 7.8%, or LGE (+)) exhibited the worst survival. In multivariate analysis, GLPSSR, HbA1c, and LGE (+) significantly predicted primary adverse cardiovascular endpoint in overall ICM/NIDCM and ICM/NIDCM patients with T2DM. CONCLUSIONS: T2DM has an additive deleterious effect on LV longitudinal function and myocardial fibrosis in ICM/NIDCM patients. Combining GLPSSR, HbA1c, and LGE could be promising markers in predicting outcomes in ICM/NIDCM patients with T2DM. EVIDENCE LEVEL: 3 TECHNICAL EFFICACY: 5. CI - (c) 2023 International Society for Magnetic Resonance in Medicine. FAU - Zhang, Hong-Kai AU - Zhang HK AUID- ORCID: 0000-0001-6191-5106 AD - Department of Radiology, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung, and Vascular Diseases, Capital Medical University, Beijing, China. FAU - Du, Yu AU - Du Y AD - Department of Cardiology, Clinical Center for Coronary Heart Disease, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. FAU - Shi, Chun-Yan AU - Shi CY AD - Department of Radiology, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung, and Vascular Diseases, Capital Medical University, Beijing, China. FAU - Zhang, Nan AU - Zhang N AD - Department of Radiology, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung, and Vascular Diseases, Capital Medical University, Beijing, China. FAU - Gao, Hui-Qiang AU - Gao HQ AD - Department of Cardiac Surgery, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Vascular Diseases, Capital Medical University, Beijing, China. FAU - Zhong, Yong-Liang AU - Zhong YL AD - Department of Cardiac Surgery, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Vascular Diseases, Capital Medical University, Beijing, China. FAU - Wang, Mao-Zhou AU - Wang MZ AD - Department of Cardiac Surgery, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Vascular Diseases, Capital Medical University, Beijing, China. FAU - Zhou, Zhen AU - Zhou Z AD - Department of Radiology, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung, and Vascular Diseases, Capital Medical University, Beijing, China. FAU - Gao, Xue-Lian AU - Gao XL AD - Department of Radiology, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung, and Vascular Diseases, Capital Medical University, Beijing, China. FAU - Li, Shuang AU - Li S AD - Department of Radiology, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung, and Vascular Diseases, Capital Medical University, Beijing, China. FAU - Yang, Lin AU - Yang L AD - Department of Radiology, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung, and Vascular Diseases, Capital Medical University, Beijing, China. FAU - Liu, Tong AU - Liu T AD - Department of Cardiology, Clinical Center for Coronary Heart Disease, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. FAU - Fan, Zhan-Ming AU - Fan ZM AD - Department of Radiology, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung, and Vascular Diseases, Capital Medical University, Beijing, China. FAU - Sun, Zhong-Hua AU - Sun ZH AD - Discipline of Medical Radiation Science, Curtin Medical School, Curtin University, Perth, Western Australia, Australia. FAU - Xu, Lei AU - Xu L AUID- ORCID: 0000-0002-8499-0448 AD - Department of Radiology, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung, and Vascular Diseases, Capital Medical University, Beijing, China. LA - eng GR - 81771791/National Natural Science Foundation of China/ GR - 82271986/National Natural Science Foundation of China/ GR - U1908211/National Natural Science Foundation of China/ GR - 2020-1-1052/Capital's Funds for Health Improvement and Research Foundation of China/ GR - 2022YFE0209800/National Key R&D Program of China/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20230404 PL - United States TA - J Magn Reson Imaging JT - Journal of magnetic resonance imaging : JMRI JID - 9105850 RN - 0 (Contrast Media) RN - 0 (Glycated Hemoglobin) RN - AU0V1LM3JT (Gadolinium) SB - IM CIN - J Magn Reson Imaging. 2024 Jan;59(1):177-178. PMID: 37093787 MH - Humans MH - *Cardiomyopathy, Dilated/complications/diagnostic imaging MH - Prognosis MH - Retrospective Studies MH - *Diabetes Mellitus, Type 2/complications MH - Contrast Media MH - Glycated Hemoglobin MH - Magnetic Resonance Imaging, Cine/methods MH - Gadolinium MH - *Cardiomyopathies MH - Ventricular Function, Left MH - Fibrosis MH - *Ventricular Dysfunction, Left/complications/diagnostic imaging MH - Ischemia OTO - NOTNLM OT - cardiac magnetic resonance OT - dilated cardiomyopathy OT - global longitudinal strain rate OT - late gadolinium enhancement OT - type 2 diabetes mellitus EDAT- 2023/04/05 06:00 MHDA- 2023/12/17 09:43 CRDT- 2023/04/04 03:54 PHST- 2023/03/22 00:00 [revised] PHST- 2022/10/25 00:00 [received] PHST- 2023/03/23 00:00 [accepted] PHST- 2023/12/17 09:43 [medline] PHST- 2023/04/05 06:00 [pubmed] PHST- 2023/04/04 03:54 [entrez] AID - 10.1002/jmri.28723 [doi] PST - ppublish SO - J Magn Reson Imaging. 2024 Jan;59(1):164-176. doi: 10.1002/jmri.28723. Epub 2023 Apr 4.