PMID- 37014456
OWN - NLM
STAT- MEDLINE
DCOM- 20230522
LR  - 20230522
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 60
IP  - 7
DP  - 2023 Jul
TI  - Prefrontal oxygenation and working memory in patients with type 2 diabetes 
      mellitus following integrated yoga: a randomized controlled trial.
PG  - 951-961
LID - 10.1007/s00592-023-02085-0 [doi]
AB  - AIMS: Type 2 diabetes mellitus (T2DM) alters brain functional and structural 
      connectivity leading to cognitive dysfunction. This study examined the effect of 
      a 12-week yoga intervention on prefrontal cortex (PFC) oxygenation and working 
      memory in patients with T2DM. METHODS: Fifty participants were randomized into 
      yoga and waitlist control groups. The yoga protocol specific to T2DM was 
      followed. The pre- (day 1), mid- (6 weeks) and post-intervention (12 weeks) 
      assessments included measurement of PFC oxygenation while performing working 
      memory tasks (n-back) using functional near-infrared spectroscopy. RESULTS: 
      Following a 12-week intervention, the yoga group showed improved performance in 
      working memory [accuracy (geometric mean difference of 3.15%, 95% CI [2.33,3.96], 
      p = 0.001) and reaction time (mean difference of 100.8 milliseconds,95% CI 
      [- 166.6, - 35.1], p = 0.002] in the high task load (2-back) associated with 
      higher oxygenation in dorsolateral PFC (beta coefficient mean difference of 95.6, 
      95% CI [0.23,191], p = 0.049) and ventrolateral PFC (beta coefficient mean 
      difference of 53.4, 95% CI [7.8,98.9], p = 0.018) regions. Higher oxygenation in 
      dorsolateral PFC during 2-back task was positively correlated with accuracy 
      (r(23) = 0.65, p < 0.001) and negatively correlated with reaction time (r(23) =  
      - 0.47,p = 0.017). CONCLUSION: Integrated yoga practice may improve working 
      memory performance associated with higher PFC oxygenation in patients with T2DM. 
      As 12 weeks of yoga intervention improved working memory performance, the regular 
      practice of yoga may have the potential to prevent decline of cognitive functions 
      in clinical conditions.
CI  - (c) 2023. Springer-Verlag Italia S.r.l., part of Springer Nature.
FAU - Kaligal, Chidananda
AU  - Kaligal C
AD  - Division of Yoga and Life Sciences, Swami Vivekananda Yoga Anusandhana, Samsthana 
      (S-VYASA), #19 Eknath Bhavan, Gavipuram Circle, K.G. Nagar, Bangalore, 560019, 
      India.
FAU - Kanthi, Amit
AU  - Kanthi A
AD  - Division of Yoga and Life Sciences, Swami Vivekananda Yoga Anusandhana, Samsthana 
      (S-VYASA), #19 Eknath Bhavan, Gavipuram Circle, K.G. Nagar, Bangalore, 560019, 
      India.
FAU - Vidyashree, M
AU  - Vidyashree M
AD  - Division of Yoga and Life Sciences, Swami Vivekananda Yoga Anusandhana, Samsthana 
      (S-VYASA), #19 Eknath Bhavan, Gavipuram Circle, K.G. Nagar, Bangalore, 560019, 
      India.
FAU - Krishna, Dwivedi
AU  - Krishna D
AD  - Division of Yoga and Life Sciences, Swami Vivekananda Yoga Anusandhana, Samsthana 
      (S-VYASA), #19 Eknath Bhavan, Gavipuram Circle, K.G. Nagar, Bangalore, 560019, 
      India.
FAU - Raghuram, Nagarathna
AU  - Raghuram N
AD  - Division of Yoga and Life Sciences, Swami Vivekananda Yoga Anusandhana, Samsthana 
      (S-VYASA), #19 Eknath Bhavan, Gavipuram Circle, K.G. Nagar, Bangalore, 560019, 
      India.
FAU - Hongasandra Ramarao, Nagendra
AU  - Hongasandra Ramarao N
AD  - Division of Yoga and Life Sciences, Swami Vivekananda Yoga Anusandhana, Samsthana 
      (S-VYASA), #19 Eknath Bhavan, Gavipuram Circle, K.G. Nagar, Bangalore, 560019, 
      India.
FAU - Deepeshwar, Singh
AU  - Deepeshwar S
AUID- ORCID: 0000-0002-9867-1405
AD  - Division of Yoga and Life Sciences, Swami Vivekananda Yoga Anusandhana, Samsthana 
      (S-VYASA), #19 Eknath Bhavan, Gavipuram Circle, K.G. Nagar, Bangalore, 560019, 
      India. deepeshwar.singh@svyasa.edu.in.
LA  - eng
GR  - Z.280152092015-HPC(EMR)-AYUSH/Ministry of Ayurveda, Yoga and Naturopathy, Unani, 
      Siddha and Homoeopathy/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20230404
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
SB  - IM
MH  - Humans
MH  - Memory, Short-Term
MH  - *Yoga/psychology
MH  - *Diabetes Mellitus, Type 2/complications/therapy
MH  - Cognition
MH  - Brain
OTO - NOTNLM
OT  - Cognitive performance
OT  - Prefrontal hemodynamics
OT  - fNIRS
OT  - n-back task
EDAT- 2023/04/05 06:00
MHDA- 2023/05/22 06:42
CRDT- 2023/04/04 11:15
PHST- 2023/02/07 00:00 [received]
PHST- 2023/03/24 00:00 [accepted]
PHST- 2023/05/22 06:42 [medline]
PHST- 2023/04/05 06:00 [pubmed]
PHST- 2023/04/04 11:15 [entrez]
AID - 10.1007/s00592-023-02085-0 [pii]
AID - 10.1007/s00592-023-02085-0 [doi]
PST - ppublish
SO  - Acta Diabetol. 2023 Jul;60(7):951-961. doi: 10.1007/s00592-023-02085-0. Epub 2023 
      Apr 4.