PMID- 37015158
OWN - NLM
STAT- MEDLINE
DCOM- 20230425
LR  - 20230425
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 118
DP  - 2023 May
TI  - Human umbilical cord-derived mesenchymal stem cells-harvested mitochondrial 
      transplantation improved motor function in TBI models through rescuing neuronal 
      cells from apoptosis and alleviating astrogliosis and microglia activation.
PG  - 110106
LID - S1567-5769(23)00427-7 [pii]
LID - 10.1016/j.intimp.2023.110106 [doi]
AB  - Each year, traumatic brain injury (TBI) causes a high rate of mortality 
      throughout the world and those who survive have lasting disabilities. Given that 
      the brain is a particularly dynamic organ with a high energy consumption rate, 
      the inefficiency of current TBI treatment options highlights the necessity of 
      repairing damaged brain tissue at the cellular and molecular levels, which 
      according to research is aggravated due to ATP deficiency and reactive oxygen 
      species surplus. Taking into account that mitochondria contribute to generating 
      energy and controlling cellular stress, mitochondrial transplantation as a new 
      treatment approach has lately reduced complications in a number of diseases by 
      supplying healthy and functional mitochondria to the damaged tissue. For this 
      reason, in this study, we used this technique to transplant human umbilical 
      cord-derived mesenchymal stem cells (hUC-MSCs)-derived mitochondria as a suitable 
      source for mitochondrial isolation into rat models of TBI to examine its 
      therapeutic benefit and the results showed that the successful mitochondrial 
      internalisation in the neuronal cells significantly reduced the number of brain 
      cells undergoing apoptosis, alleviated astrogliosis and microglia activation, 
      retained normal brain morphology and cytoarchitecture, and improved sensorimotor 
      functions in a rat model of TBI. These data indicate that human umbilical 
      cord-derived mesenchymal stem cells-isolated mitochondrial transplantation 
      improves motor function in a rat model of TBI via rescuing neuronal cells from 
      apoptosis and alleviating astrogliosis and microglia activation, maybe as a 
      result of restoring the lost mitochondrial content.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Bamshad, Chia
AU  - Bamshad C
AD  - Department of Medical Biotechnology, Faculty of Paramedicine, Guilan University 
      of Medical Sciences, Rasht, Iran.
FAU - Habibi Roudkenar, Mehryar
AU  - Habibi Roudkenar M
AD  - Burn and Regenerative Medicine Research Center, Velayat Hospital, School of 
      Medicine, Guilan University of Medical Sciences, Rasht, Iran.
FAU - Abedinzade, Mahmoud
AU  - Abedinzade M
AD  - Department of Operation Room, Faculty of Paramedicine, Guilan University of 
      Medical Sciences, Rasht, Iran.
FAU - Yousefzadeh Chabok, Shahrokh
AU  - Yousefzadeh Chabok S
AD  - Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, 
      Iran.
FAU - Pourmohammadi-Bejarpasi, Zahra
AU  - Pourmohammadi-Bejarpasi Z
AD  - Burn and Regenerative Medicine Research Center, Velayat Hospital, School of 
      Medicine, Guilan University of Medical Sciences, Rasht, Iran.
FAU - Najafi-Ghalehlou, Nima
AU  - Najafi-Ghalehlou N
AD  - Department of Medical Laboratory Sciences, Faculty of Paramedicine, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Sato, Tomoaki
AU  - Sato T
AD  - Department of Applied Pharmacology, Graduate School of Medical and Dental 
      Sciences, Kagoshima University, Kagoshima, Japan.
FAU - Tomita, Kazuo
AU  - Tomita K
AD  - Department of Applied Pharmacology, Graduate School of Medical and Dental 
      Sciences, Kagoshima University, Kagoshima, Japan.
FAU - Jahanian-Najafabadi, Ali
AU  - Jahanian-Najafabadi A
AD  - Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical 
      Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
FAU - Feizkhah, Alireza
AU  - Feizkhah A
AD  - Burn and Regenerative Medicine Research Center, Velayat Hospital, School of 
      Medicine, Guilan University of Medical Sciences, Rasht, Iran.
FAU - Mohammadi Roushandeh, Amaneh
AU  - Mohammadi Roushandeh A
AD  - Burn and Regenerative Medicine Research Center, Velayat Hospital, School of 
      Medicine, Guilan University of Medical Sciences, Rasht, Iran. Electronic address: 
      mohammadi_roushandeh@gums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20230402
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
SB  - IM
MH  - Humans
MH  - Rats
MH  - Animals
MH  - Gliosis
MH  - Microglia
MH  - *Mesenchymal Stem Cell Transplantation
MH  - *Brain Injuries, Traumatic
MH  - Mitochondria
MH  - Apoptosis/physiology
MH  - *Mesenchymal Stem Cells
MH  - Umbilical Cord
OTO - NOTNLM
OT  - Apoptosis
OT  - Mesenchymal stem cells
OT  - Mitochondrial transplantation
OT  - Sensorimotor behaviour
OT  - Traumatic brain injury
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/04/05 06:00
MHDA- 2023/04/25 06:42
CRDT- 2023/04/04 18:00
PHST- 2022/11/12 00:00 [received]
PHST- 2023/02/09 00:00 [revised]
PHST- 2023/03/24 00:00 [accepted]
PHST- 2023/04/25 06:42 [medline]
PHST- 2023/04/05 06:00 [pubmed]
PHST- 2023/04/04 18:00 [entrez]
AID - S1567-5769(23)00427-7 [pii]
AID - 10.1016/j.intimp.2023.110106 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2023 May;118:110106. doi: 10.1016/j.intimp.2023.110106. Epub 
      2023 Apr 2.