PMID- 37017835
OWN - NLM
STAT- MEDLINE
DCOM- 20230510
LR  - 20230510
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 21
DP  - 2023 May
TI  - Attenuating effects of selenium and zinc against hexavalent chromium-induced 
      oxidative stress, hormonal instability, and placenta damage in preimplanted rats.
PG  - 60050-60079
LID - 10.1007/s11356-023-26700-3 [doi]
AB  - As a toxic metal, hexavalent chromium (CrVI) has effects on both the reproductive 
      and endocrine systems. This study aimed to evaluate the protective effects of 
      selenium (Se) and zinc (Zn) against the toxicity of chromium on the placenta in 
      pregnant Wistar albino rats. Thirty pregnant Wistar rats were divided into 
      control and four treated groups, receiving subcutaneously (s.c) on the 3rd day of 
      pregnancy, K(2)Cr(2)O(7) (10 mg/kg body weight (bw)) alone, or in association 
      with Se (0.3 mg/kg bw), ZnCl(2) (20 mg/kg bw), or both of them simultaneously. 
      Plasma steroid hormones, placenta histoarchitecture, oxidative stress profile, 
      and developmental parameters were investigated. These results showed that 
      K(2)Cr(2)O(7) exposure induced a significant increase in the levels of both 
      plasma estradiol (E(2)) and placenta malondialdehyde (MDA), the number of fetal 
      resorptions, and percent of post-implantation loss. On the other hand, 
      K(2)Cr(2)O(7) significantly reduced developmental parameters, maternal body and 
      placenta weight, and plasma progesterone (P) and chorionic gonadotropin hormone 
      (beta HCG) levels. However, K(2)Cr(2)O(7) significantly decreased the placenta 
      activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), reduced 
      glutathione (GSH), and nonprotein sulfhydryl (NPSH). These changes have been 
      reinforced by histopathological evaluation of the placenta. Se and/or ZnCl(2) 
      supplementation provoked a significant improvement in most indices. These results 
      suggest that the co-treatment with Se or ZnCl(2) strongly opposes the placenta 
      cytotoxicity induced by K(2)Cr(2)O(7) through its antioxidant action.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Saouli, Asma
AU  - Saouli A
AUID- ORCID: 0000-0002-6132-1620
AD  - Laboratory of Cellular and Molecular Physio-Toxicology-Pathology and 
      Biomolecules, Department of Biology of Organisms, Faculty of Natural and Life 
      Sciences, University of Batna 2, 5000, Batna, Algeria. a.saouli@univ-batna2.dz.
FAU - Adjroud, Ounassa
AU  - Adjroud O
AD  - Laboratory of Cellular and Molecular Physio-Toxicology-Pathology and 
      Biomolecules, Department of Biology of Organisms, Faculty of Natural and Life 
      Sciences, University of Batna 2, 5000, Batna, Algeria.
FAU - Ncir, Marwa
AU  - Ncir M
AD  - Animal Eco-Physiology Laboratory, Department of Life Sciences, Sciences Faculty 
      of Sfax, University of Sfax, BP 1171, 3000, Sfax, Tunisia.
FAU - Bachir, Achouak
AU  - Bachir A
AD  - Anatomy and Pathology Laboratory, EHS Salim Zemirli, 16200, El Harrach, Algeria.
FAU - El Feki, Abdelfattah
AU  - El Feki A
AD  - Animal Eco-Physiology Laboratory, Department of Life Sciences, Sciences Faculty 
      of Sfax, University of Sfax, BP 1171, 3000, Sfax, Tunisia.
LA  - eng
GR  - N  degrees  E2212600/DGRSDT/ MESRS, Algeria./
PT  - Journal Article
DEP - 20230405
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - H6241UJ22B (Selenium)
RN  - J41CSQ7QDS (Zinc)
RN  - 18540-29-9 (chromium hexavalent ion)
RN  - 0 (Antioxidants)
RN  - 0R0008Q3JB (Chromium)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Animals
MH  - Rats
MH  - *Selenium/pharmacology
MH  - Zinc/pharmacology
MH  - Rats, Wistar
MH  - Oxidative Stress
MH  - Antioxidants/pharmacology/metabolism
MH  - Chromium/toxicity
MH  - Superoxide Dismutase/metabolism
MH  - Glutathione/pharmacology
MH  - Placenta/metabolism
OTO - NOTNLM
OT  - Hexavalent chromium
OT  - Histopathology
OT  - Oxidative stress
OT  - Placenta
OT  - Reproductive toxicity
OT  - Selenium
OT  - Steroid hormones
OT  - Zinc
EDAT- 2023/04/06 06:00
MHDA- 2023/05/10 06:41
CRDT- 2023/04/05 11:18
PHST- 2021/10/05 00:00 [received]
PHST- 2023/03/24 00:00 [accepted]
PHST- 2023/05/10 06:41 [medline]
PHST- 2023/04/06 06:00 [pubmed]
PHST- 2023/04/05 11:18 [entrez]
AID - 10.1007/s11356-023-26700-3 [pii]
AID - 10.1007/s11356-023-26700-3 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 May;30(21):60050-60079. doi: 
      10.1007/s11356-023-26700-3. Epub 2023 Apr 5.