PMID- 37018834
OWN - NLM
STAT- MEDLINE
DCOM- 20230407
LR  - 20230407
IS  - 1678-2690 (Electronic)
IS  - 0001-3765 (Linking)
VI  - 95
IP  - 2
DP  - 2023
TI  - Fisetin Attenuates Paracetamol-Induced Hepatotoxicity by Regulating CYP2E1 
      Enzyme.
PG  - e20201408
LID - S0001-37652023000300702 [pii]
LID - 10.1590/0001-3765202320201408 [doi]
AB  - Paracetamol is one of the drugs that cause hepatic damage. Fisetin has wide 
      pharmacological effects such as anticancer, antiinflammatory and antioxidant. We 
      aimed to evaluate the possible protective effect of fisetin on 
      paracetamol-induced hepatotoxicity. Fisetin was administered at 25 and 50 mg/kg 
      doses. Paracetamol was administered orally at a dose of 2 g/kg for induce 
      hepatotoxicity 1 h after the fisetin and NAC treatments. The rats were sacrificed 
      24h after the Paracetamol administration. Tumor necrosis factor-alpha (TNF-alpha), 
      NFkappaB and CYP2E1 mRNA levels and Superoxide dismutase (SOD) activity, glutathione 
      (GSH) and malondialdehyde (MDA) levels of livers were determined. Serum ALT, AST 
      and ALP levels were measured. Histopathological examinations were also performed. 
      Fisetin administration significantly decreased the ALT, AST and ALP levels in a 
      dose dependent manner. In addition, SOD activity and GSH levels increased, and 
      the MDA level decreased with the treatment of fisetin. The TNF-alpha, NFkappaB and CYP2E1 
      gene expressions were significantly lower in both doses of the fisetin groups 
      compared with the PARA group. Histopathological examinations showed that fisetin 
      has hepatoprotective effects. This study showed that fisetin has the liver 
      protective effects by increasing GSH, decreasing inflammatory mediators and 
      CYP2E1.
FAU - Ugan, Rustem A
AU  - Ugan RA
AUID- ORCID: 0000-0002-4837-2343
AD  - Ataturk University, Faculty of Pharmacy, Department of Pharmacology, 25240, 
      Erzurum, Turkey.
AD  - Ataturk University, Clinical Research, Development and Design Application and 
      Research Center, 25240, Erzurum, Turkey.
FAU - Cadirci, Elif
AU  - Cadirci E
AUID- ORCID: 0000-0003-0836-7205
AD  - Ataturk University, Faculty of Medicine, Department of Pharmacology, 25240, 
      Erzurum, Turkey.
AD  - Ataturk University, Clinical Research, Development and Design Application and 
      Research Center, 25240, Erzurum, Turkey.
FAU - Un, Harun
AU  - Un H
AUID- ORCID: 0000-0003-1772-282X
AD  - Agri Ibrahim Cecen University, Faculty of Pharmacy, Department of Biochemistry, 
      04100, Agri, Turkey.
FAU - Cinar, Irfan
AU  - Cinar I
AUID- ORCID: 0000-0002-9826-2556
AD  - Kafkas University, Faculty of Medicine, Department of Pharmacology, Kars, 36200, 
      Turkey.
FAU - Gurbuz, Muhammet A
AU  - Gurbuz MA
AUID- ORCID: 0000-0001-8750-2393
AD  - Ataturk University, Faculty of Medicine, Department of Histology and Embryology, 
      25240, Erzurum, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20230403
PL  - Brazil
TA  - An Acad Bras Cienc
JT  - Anais da Academia Brasileira de Ciencias
JID - 7503280
RN  - 362O9ITL9D (Acetaminophen)
RN  - OO2ABO9578 (fisetin)
RN  - EC 1.14.13.- (Cytochrome P-450 CYP2E1)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Antioxidants)
RN  - GAN16C9B8O (Glutathione)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Rats
MH  - Animals
MH  - *Acetaminophen/pharmacology
MH  - Cytochrome P-450 CYP2E1/metabolism/pharmacology
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Antioxidants/pharmacology
MH  - Liver
MH  - Glutathione
MH  - *Chemical and Drug Induced Liver Injury/drug therapy
MH  - Superoxide Dismutase/metabolism
MH  - Oxidative Stress
EDAT- 2023/04/06 06:00
MHDA- 2023/04/07 06:41
CRDT- 2023/04/05 17:43
PHST- 2020/08/31 00:00 [received]
PHST- 2020/11/14 00:00 [accepted]
PHST- 2023/04/07 06:41 [medline]
PHST- 2023/04/05 17:43 [entrez]
PHST- 2023/04/06 06:00 [pubmed]
AID - S0001-37652023000300702 [pii]
AID - 10.1590/0001-3765202320201408 [doi]
PST - epublish
SO  - An Acad Bras Cienc. 2023 Apr 3;95(2):e20201408. doi: 
      10.1590/0001-3765202320201408. eCollection 2023.