PMID- 37019047
OWN - NLM
STAT- MEDLINE
DCOM- 20230418
LR  - 20230420
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 175
DP  - 2023 May
TI  - Similarities and differences in kinetic characteristics of airways inflammation, 
      formation of inducible bronchial-associated lymphoid tissue and remodeling 
      between young and old murine asthma surrogates induced with house dust mite.
PG  - 112160
LID - S0531-5565(23)00081-5 [pii]
LID - 10.1016/j.exger.2023.112160 [doi]
AB  - Elderly asthmatics have higher morbidity and mortality compared with those of 
      youngers. It has been shown that there are also some differences in clinic 
      phenomena between young and elderly asthmatics, however, there is lack of the 
      kinetic comparisons of the changes in the development of asthma between two 
      populations. To better understand the specific pathophysiological manifestations 
      in older patients with asthma, we dynamically and parallelly compared 
      pathophysiological changes in the airways and lung tissues between young and old 
      murine asthma surrogates based on sensitization and challenge with house dust 
      mite (HDM). Murine models were established in young (6-8-week-old) and old 
      (16-17-month-old) female wild-type C57BL/6 mice. Our data showed that repetitive 
      HDM exposure induced relatively low type 2 immune responses (airway 
      hyperresponsiveness, eosinophils recruitment, expression of type 2 cytokines, 
      mucus secretion, serum HDM specific immunoglobulin E (IgE) and IgG) in old mice. 
      However, the type 3 immune responses (neutrophils infiltration and IL-17A 
      expression) were enhanced in old HDM exposed mice, which sustained longer and 
      higher than that of young mice. Notably, the relatively weakened allergic 
      inflammation characteristics might be associated with lower numbers of CD20(+) B 
      cells and IgE(+) cells in the iBALTs in old mice compared with those in young 
      mice. Our data suggest that aging might compromise the ability to induce type 2 
      immune responses, but enhance type 3 immune responses upon repetitive HDM 
      challenge, which might cause relevant phenomena in old experimental mice and 
      might even be applicable to elderly patients with asthma in the clinic.
CI  - Copyright (c) 2023. Published by Elsevier Inc.
FAU - Fu, Tingting
AU  - Fu T
AD  - Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, 
      Capital Medical University & Beijing Institute of Respiratory Medicine, Beijing, 
      China.
FAU - Liu, Jing
AU  - Liu J
AD  - Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, 
      Capital Medical University & Beijing Institute of Respiratory Medicine, Beijing, 
      China.
FAU - Wang, Wenjun
AU  - Wang W
AD  - Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, 
      Capital Medical University & Beijing Institute of Respiratory Medicine, Beijing, 
      China.
FAU - Li, Yan
AU  - Li Y
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren 
      Hospital, Capital Medical University, Beijing Institute of Otorhinolaryngology, 
      Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of 
      Education, Beijing Key Laboratory of Nasal Diseases, Beijing, China.
FAU - Wang, Yunhan
AU  - Wang Y
AD  - Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, 
      Capital Medical University & Beijing Institute of Respiratory Medicine, Beijing, 
      China.
FAU - Cui, Lele
AU  - Cui L
AD  - Department of Immunology, School of Basic Medical Sciences, Capital Medical 
      University, Beijing, China.
FAU - Liu, Meishan
AU  - Liu M
AD  - Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, 
      Capital Medical University & Beijing Institute of Respiratory Medicine, Beijing, 
      China.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Immunology, School of Basic Medical Sciences, Capital Medical 
      University, Beijing, China.
FAU - Ying, Sun
AU  - Ying S
AD  - Department of Immunology, School of Basic Medical Sciences, Capital Medical 
      University, Beijing, China. Electronic address: ying.sun@ccmu.edu.cn.
FAU - Huang, Kewu
AU  - Huang K
AD  - Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, 
      Capital Medical University & Beijing Institute of Respiratory Medicine, Beijing, 
      China. Electronic address: kewuhuang@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230403
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Cytokines)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Female
MH  - Animals
MH  - Mice
MH  - *Pyroglyphidae/metabolism
MH  - Mice, Inbred C57BL
MH  - *Asthma/metabolism
MH  - Lung
MH  - Inflammation/metabolism
MH  - Cytokines/metabolism
MH  - Immunoglobulin E/metabolism
MH  - Lymphoid Tissue
MH  - Disease Models, Animal
OTO - NOTNLM
OT  - Aging
OT  - Asthma
OT  - Immune responses
OT  - Inducible bronchial-associated lymphoid tissue
OT  - Mouse model
COIS- Declaration of competing interest The authors declare no conflicts of interest.
EDAT- 2023/04/06 06:00
MHDA- 2023/04/18 06:42
CRDT- 2023/04/05 18:08
PHST- 2023/01/04 00:00 [received]
PHST- 2023/03/22 00:00 [revised]
PHST- 2023/03/23 00:00 [accepted]
PHST- 2023/04/18 06:42 [medline]
PHST- 2023/04/06 06:00 [pubmed]
PHST- 2023/04/05 18:08 [entrez]
AID - S0531-5565(23)00081-5 [pii]
AID - 10.1016/j.exger.2023.112160 [doi]
PST - ppublish
SO  - Exp Gerontol. 2023 May;175:112160. doi: 10.1016/j.exger.2023.112160. Epub 2023 
      Apr 3.