PMID- 37019819
OWN - NLM
STAT- MEDLINE
DCOM- 20230420
LR  - 20230519
IS  - 1460-2709 (Electronic)
IS  - 1369-3786 (Print)
IS  - 1369-3786 (Linking)
VI  - 61
IP  - 4
DP  - 2023 Apr 3
TI  - Time-to-positivity in bloodstream infection for Candida species as a prognostic 
      marker for mortality.
LID - 10.1093/mmy/myad028 [doi]
LID - myad028
AB  - Time-to-positivity (TTP) may assist in predicting the outcome of candidaemia. We 
      analysed a candidaemia dataset collected prospectively in Australia over 1 year 
      (2014-2015). TTP was defined as the period from blood culture sampling to the 
      blood culture flagging positive. Of 415 candidaemia episodes, overall, 30-day 
      mortality was 29% (120/415); mortality with Candida albicans was 35% (59/169), C. 
      glabrata complex, 37% (43/115), C. tropicalis, 43% (10/23), Pichia kudriavzevii 
      25% (3/12), and C. parapsilosis complex 7% (5/71). Each day of increased TTP 
      multiplied the odds ratio (OR) of survival at 30 days by a factor of 1.32 [95% 
      confidence interval (CI) 1.06-1.69]. Shorter TTP was associated with increased 
      mortality, with 1-day TTP associated with 30-day mortality 37% (41/112) (95%CI: 
      28%-46%) and 5-day TTP 11% (2/18) (95%CI: 2%-36%).
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of The 
      International Society for Human and Animal Mycology.
FAU - Keighley, Caitlin
AU  - Keighley C
AUID- ORCID: 0000-0002-8892-3488
AD  - Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of 
      Clinical Pathology and Medical Research, New South Wales Health Pathology, 
      Westmead Hospital, Sydney, NSW 2145, Australia.
AD  - University of Sydney Institute for Infectious Diseases, Westmead, Sydney, NSW 
      2156, Australia.
AD  - Southern.IML Pathology, Sonic Healthcare, Coniston NSW 2500, Australia.
FAU - Pope, Alun L
AU  - Pope AL
AD  - Eastern Health Clinical School, Monash University, Melbourne, Victoria 3124, 
      Australia.
AD  - Analytical Insight, Crawley 6009, WA, Australia.
FAU - Marriott, Debbie
AU  - Marriott D
AD  - Department of Microbiology and Infectious Diseases, St. Vincent's Hospital, 
      Sydney 2010, NSW, Australia.
FAU - Chen, Sharon C-A
AU  - Chen SC
AD  - Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of 
      Clinical Pathology and Medical Research, New South Wales Health Pathology, 
      Westmead Hospital, Sydney, NSW 2145, Australia.
AD  - University of Sydney Institute for Infectious Diseases, Westmead, Sydney, NSW 
      2156, Australia.
FAU - Slavin, Monica A
AU  - Slavin MA
AD  - Department of Infectious Diseases, Peter MacCallum Cancer Centre, National Centre 
      for Infections in Cancer, Melbourne, VIC 3052, Australia.
CN  - Australia and New Zealand Mycoses Interest Group
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Mycol
JT  - Medical mycology
JID - 9815835
RN  - 0 (Antifungal Agents)
SB  - IM
MH  - Animals
MH  - *Candida
MH  - Prognosis
MH  - *Candidemia/drug therapy/veterinary
MH  - Candida glabrata
MH  - Candida albicans
MH  - Candida tropicalis
MH  - Candida parapsilosis
MH  - Antifungal Agents/therapeutic use
PMC - PMC10189360
OAB - Time-to-positivity is a measure that is available to clinicians when patients are 
      identified as having candida in their bloodstream. Our data support the 
      association of a shorter time to positivity with higher mortality.
OABL- eng
OTO - NOTNLM
OT  - candidaemia
OT  - bloodstream infection
OT  - candida
OT  - mortality
OT  - time to positivity
FIR - Arthur, Ian
IR  - Arthur I
FIR - Baird, Rob
IR  - Baird R
FIR - Bak, Narin
IR  - Bak N
FIR - Blyth, Christopher
IR  - Blyth C
FIR - Botes, Jeannie
IR  - Botes J
FIR - Chapman, Belinda
IR  - Chapman B
FIR - Cheong, Elaine
IR  - Cheong E
FIR - Cooley, Louise
IR  - Cooley L
FIR - Daveson, Kathryn
IR  - Daveson K
FIR - George, Rob
IR  - George R
FIR - Goeman, Emma
IR  - Goeman E
FIR - Hajkowicz, Krispin
IR  - Hajkowicz K
FIR - Halliday, Catriona
IR  - Halliday C
FIR - Heath, Christopher H
IR  - Heath CH
FIR - Hofmeyr, Ann
IR  - Hofmeyr A
FIR - Kalukottege, Pankaja
IR  - Kalukottege P
FIR - Kesson, Alison
IR  - Kesson A
FIR - Kennedy, Karina
IR  - Kennedy K
FIR - Kidd, Sarah
IR  - Kidd S
FIR - Korman, Tony M
IR  - Korman TM
FIR - Leung, Michael
IR  - Leung M
FIR - Liu, Eunice
IR  - Liu E
FIR - Macesic, Nenad
IR  - Macesic N
FIR - McDonald, Kyle
IR  - McDonald K
FIR - McMullan, Brendan
IR  - McMullan B
FIR - Morrissey, Orla
IR  - Morrissey O
FIR - Pendle, Stella
IR  - Pendle S
FIR - Robson, Jenny
IR  - Robson J
FIR - Sorrell, Tania
IR  - Sorrell T
FIR - Underwood, Neil
IR  - Underwood N
FIR - van Hal, Sebastian
IR  - van Hal S
FIR - Weeks, Kerry
IR  - Weeks K
FIR - Wilson, Heather
IR  - Wilson H
EDAT- 2023/04/06 06:00
MHDA- 2023/04/20 06:42
PMCR- 2023/04/05
CRDT- 2023/04/05 22:22
PHST- 2022/10/14 00:00 [received]
PHST- 2023/04/03 00:00 [accepted]
PHST- 2023/01/03 00:00 [revised]
PHST- 2023/04/20 06:42 [medline]
PHST- 2023/04/06 06:00 [pubmed]
PHST- 2023/04/05 22:22 [entrez]
PHST- 2023/04/05 00:00 [pmc-release]
AID - 7109268 [pii]
AID - myad028 [pii]
AID - 10.1093/mmy/myad028 [doi]
PST - ppublish
SO  - Med Mycol. 2023 Apr 3;61(4):myad028. doi: 10.1093/mmy/myad028.