PMID- 37021143
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230407
IS  - 2213-0071 (Print)
IS  - 2213-0071 (Electronic)
IS  - 2213-0071 (Linking)
VI  - 43
DP  - 2023
TI  - Dyspnea and cough in a 68-year-old female with light chain deposition disease.
PG  - 101839
LID - 10.1016/j.rmcr.2023.101839 [doi]
LID - 101839
AB  - Light chain deposition disease (LCDD) is a rare hematologic disorder 
      characterized by non-amyloid monoclonal immunoglobulin light chain deposition in 
      multiple organs. Pulmonary LCDD (PLCDD) is an uncommon manifestation of LCDD 
      usually seen in middle-aged patients presenting with radiologic cystic and 
      nodular findings. We report the case of a 68-year-old female who presented with 
      shortness of breath and atypical chest pain. Chest computerized tomography (CT) 
      scan revealed numerous diffuse but basilar predominant pulmonary cysts and mild 
      bronchiectasis without nodular disease. Given concomitant abnormal renal function 
      and hepatic laboratory indices, she underwent biopsy of both organs confirming 
      the presence of LCDD. Directed chemotherapy was initiated and stabilized renal 
      and hepatic progression, but on follow-up imaging, pulmonary disease appeared 
      worse. While therapeutic options targeting other organ involvement are available, 
      their directed efficacy for progressive lung disease is not well known.
CI  - (c) 2023 The Authors.
FAU - Pornchai, Angsupat
AU  - Pornchai A
AD  - Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, USA.
FAU - Moua, Teng
AU  - Moua T
AD  - Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, USA.
LA  - eng
PT  - Case Reports
DEP - 20230320
PL  - England
TA  - Respir Med Case Rep
JT  - Respiratory medicine case reports
JID - 101604463
PMC - PMC10068249
OTO - NOTNLM
OT  - Cystic lung disease
OT  - Light chain deposition disease
COIS- None.The authors report no disclosures or conflicts of interest with the 
      submission of this case report.
EDAT- 2023/04/07 06:00
MHDA- 2023/04/07 06:01
PMCR- 2023/03/20
CRDT- 2023/04/06 02:16
PHST- 2022/10/18 00:00 [received]
PHST- 2023/01/31 00:00 [revised]
PHST- 2023/03/17 00:00 [accepted]
PHST- 2023/04/07 06:01 [medline]
PHST- 2023/04/06 02:16 [entrez]
PHST- 2023/04/07 06:00 [pubmed]
PHST- 2023/03/20 00:00 [pmc-release]
AID - S2213-0071(23)00034-5 [pii]
AID - 101839 [pii]
AID - 10.1016/j.rmcr.2023.101839 [doi]
PST - epublish
SO  - Respir Med Case Rep. 2023 Mar 20;43:101839. doi: 10.1016/j.rmcr.2023.101839. 
      eCollection 2023.