PMID- 37023822
OWN - NLM
STAT- MEDLINE
DCOM- 20230601
LR  - 20230601
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 882
DP  - 2023 Jul 15
TI  - Association of urinary exposure to multiple metal(loid)s with kidney function 
      from a national cross-sectional study.
PG  - 163100
LID - S0048-9697(23)01719-9 [pii]
LID - 10.1016/j.scitotenv.2023.163100 [doi]
AB  - BACKGROUND: Arsenic (As), cadmium (Cd) and copper (Cu) are hazardous for kidney 
      function, while the effects of selenium (Se) and zinc (Zn) were unexplored for 
      the narrow safe range of intake. Interactions exists between these multiple 
      metal/metalloid exposures, but few studies have investigated the effects. 
      METHODS: A cross-sectional survey was performed among 2210 adults across twelve 
      provinces in China between 2020 and 2021. Urinary As, Cd, Cu, Se and Zn were 
      measured using inductively coupled plasma-mass spectrometry (ICP-MS). Serum 
      creatinine (Scr) and N-acetyl-beta-D glucosaminidases (urine NAG) were quantified 
      in serum and urine, respectively. Kidney function was evaluated by the estimated 
      glomerular filtration rate (eGFR). We employed logistic regression and Bayesian 
      kernel machine regression (BKMR) models to explore the individual and joint 
      effects of urinary metals/metalloids on the risk of impaired renal function (IRF) 
      or chronic kidney disease (CKD), respectively. RESULTS: Association was found 
      between As (OR = 1.24, 95 % CI: 1.03, 1.48), Cd (OR = 1.65, 95 % CI: 1.35, 2.02), 
      Cu (OR = 1.90, 95 % CI: 1.59, 2.29), Se (OR = 1.51, 95 % CI: 1.24, 1.85) and Zn 
      (OR = 1.33, 95 % CI: 1.09, 1.64) and the risk of CKD. Moreover, we observed 
      association between As (OR = 1.18, 95 % CI: 1.07, 1.29), Cu (OR = 1.14, 95 % CI: 
      1.04, 1.25), Se (OR = 1.15, 95 % CI: 1.06, 1.26) and Zn (OR = 1.12, 95 % CI: 
      1.02, 1.22) and the risk of IRF. Additionally, it was found that Se exposure may 
      strength the association of urinary As, Cd and Cu with IRF. Furthermore, it is 
      worth noting that Se and Cu contributed greatest to the inverse association in 
      IRF and CKD, respectively. CONCLUSION: Our findings suggested that 
      metal/metalloid mixtures were associated with kidney dysfunction, Se and Cu were 
      inverse factors. Additionally, interactions between them may affect the 
      association. Further studies are needed to assess the potential risks for 
      metal/metalloid exposures.
CI  - Copyright (c) 2023. Published by Elsevier B.V.
FAU - Yu, Yunjiang
AU  - Yu Y
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou 510655, PR China. Electronic address: 
      yuyunjiang@scies.org.
FAU - Meng, Wenjie
AU  - Meng W
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou 510655, PR China.
FAU - Kuang, Hongxuan
AU  - Kuang H
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou 510655, PR China.
FAU - Chen, Xichao
AU  - Chen X
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou 510655, PR China.
FAU - Zhu, Xiaohui
AU  - Zhu X
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou 510655, PR China.
FAU - Wang, Lebing
AU  - Wang L
AD  - Guangdong Provincial Engineering Technology Research Center of Environmental 
      Pollution and Health Risk Assessment, Department of Occupational and 
      Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 
      510080, PR China.
FAU - Tan, Haiping
AU  - Tan H
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou 510655, PR China.
FAU - Xu, Yujie
AU  - Xu Y
AD  - Guangdong Provincial Engineering Technology Research Center of Environmental 
      Pollution and Health Risk Assessment, Department of Occupational and 
      Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 
      510080, PR China.
FAU - Ding, Ping
AU  - Ding P
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou 510655, PR China.
FAU - Xiang, Mingdeng
AU  - Xiang M
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou 510655, PR China.
FAU - Hu, Guocheng
AU  - Hu G
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou 510655, PR China.
FAU - Zhou, Yang
AU  - Zhou Y
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Environmental Protection, Guangzhou 510655, PR China; Guangdong Provincial 
      Engineering Technology Research Center of Environmental Pollution and Health Risk 
      Assessment, Department of Occupational and Environmental Health, School of Public 
      Health, Sun Yat-sen University, Guangzhou 510080, PR China. Electronic address: 
      zhouyang@scies.org.
FAU - Dong, Guang-Hui
AU  - Dong GH
AD  - Guangdong Provincial Engineering Technology Research Center of Environmental 
      Pollution and Health Risk Assessment, Department of Occupational and 
      Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 
      510080, PR China. Electronic address: donggh5@mail.sysu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230405
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 00BH33GNGH (Cadmium)
RN  - 0 (Metals)
RN  - N712M78A8G (Arsenic)
RN  - H6241UJ22B (Selenium)
RN  - 0 (Metalloids)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Cross-Sectional Studies
MH  - Cadmium
MH  - Bayes Theorem
MH  - Metals
MH  - *Arsenic/urine
MH  - *Selenium
MH  - *Renal Insufficiency, Chronic/chemically induced/epidemiology
MH  - *Metalloids
MH  - Kidney
OTO - NOTNLM
OT  - Chronic kidney disease
OT  - Joint effect
OT  - Selenium
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/04/07 06:00
MHDA- 2023/06/01 06:42
CRDT- 2023/04/06 19:23
PHST- 2023/01/01 00:00 [received]
PHST- 2023/03/21 00:00 [revised]
PHST- 2023/03/23 00:00 [accepted]
PHST- 2023/06/01 06:42 [medline]
PHST- 2023/04/07 06:00 [pubmed]
PHST- 2023/04/06 19:23 [entrez]
AID - S0048-9697(23)01719-9 [pii]
AID - 10.1016/j.scitotenv.2023.163100 [doi]
PST - ppublish
SO  - Sci Total Environ. 2023 Jul 15;882:163100. doi: 10.1016/j.scitotenv.2023.163100. 
      Epub 2023 Apr 5.