PMID- 37024641
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231023
IS  - 1447-073X (Electronic)
IS  - 1447-073X (Linking)
VI  - 98
IP  - 4
DP  - 2023 Sep
TI  - Inhibitory effect of parthenolide on peripheral nerve degeneration.
PG  - 529-539
LID - 10.1007/s12565-023-00718-6 [doi]
AB  - Traumatic axonal damage disrupts connections between neurons, leading to the loss 
      of motor and sensory functions. Although damaged peripheral nerves can 
      regenerate, recovery depends on the variety and severity of nerve damage. Thus, 
      many phytochemicals have been studied for their ability to reduce peripheral 
      nerve degeneration, and among them, Parthenolide (PTL), which is extracted from 
      Feverfew has effects against production of free radicals, inflammation, and 
      apoptosis. Thus, we conducted a study to investigate whether PTL has an 
      inhibitory effect on peripheral nerve degeneration during peripheral nerve 
      damage. To verify the effect of PTL on peripheral nerve degeneration process, a 
      morphological comparison of peripheral nerves with and without PTL was performed. 
      PTL significantly reduced the quantity of fragmented ovoid formations at 3DIV 
      (days in vitro). Immunostaining for MBP revealed that the ratio of intact myelin 
      sheaths increased significantly in sciatic nerve with PTL compared with absence 
      of PTL at 3DIV. Furthermore, nerve fibers in the presence of PTL maintained the 
      continuity of Neurofilament (NF) compared to those without at 3DIV. 
      Immunostaining for LAMP1 and p75 NTR showed that the expression of LAMP1 and p75 
      NTR decreased in the nerve after PTL addition at 3DIV. Lastly, immunostaining for 
      anti-Ki67 revealed that PTL inhibited Ki67 expression at 3DIV compared to without 
      PTL. These results confirm that PTL inhibits peripheral nerve degenerative 
      processes. PTL may be a good applicant to inhibit peripheral nerve degeneration. 
      Our study examined the effect of Parthenolide in preventing degeneration of 
      peripheral nerves by inhibiting the breakdown of peripheral axons and myelin, 
      also inhibiting Schwann cell trans-dedifferentiation and proliferation.
CI  - (c) 2023. The Author(s), under exclusive licence to Japanese Association of 
      Anatomists.
FAU - Kim, Jung Min
AU  - Kim JM
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Kyung Hee University 
      School of Medicine, Kyung Hee University Medical Center, Seoul, 02447, Korea.
FAU - Choi, Jae Sun
AU  - Choi JS
AD  - Clinical Research Institute, Kyung Hee Medical Center, Seou, 02447, Korea.
FAU - Jung, Junyang
AU  - Jung J
AD  - Department of Anatomy and Neurobiology, College of Medicines, Kyung Hee 
      University, Seoul, 02447, Korea.
FAU - Yeo, Seung Geun
AU  - Yeo SG
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Kyung Hee University 
      School of Medicine, Kyung Hee University Medical Center, Seoul, 02447, Korea.
FAU - Kim, Sang Hoon
AU  - Kim SH
AUID- ORCID: 0000-0001-5045-5060
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Kyung Hee University 
      School of Medicine, Kyung Hee University Medical Center, Seoul, 02447, Korea. 
      hoon0700@naver.com.
AD  - Department of Otohinolaryngology - H & N Surgery, School of Medicine, KyungHee 
      University, #1 Hoegi-Dong, Dongdaemun-Gu, Seoul, 130-702, Korea. 
      hoon0700@naver.com.
LA  - eng
GR  - 2022R1F1A1072918/Ministry of Science and ICT, South Korea/
PT  - Journal Article
DEP - 20230406
PL  - Japan
TA  - Anat Sci Int
JT  - Anatomical science international
JID - 101154140
RN  - 2RDB26I5ZB (parthenolide)
RN  - 0 (Sesquiterpenes)
SB  - IM
MH  - Humans
MH  - Axons
MH  - Schwann Cells/pathology
MH  - *Sesquiterpenes/pharmacology/metabolism
MH  - Nerve Degeneration/drug therapy/metabolism/pathology
MH  - Sciatic Nerve/pathology
MH  - *Peripheral Nervous System Diseases/pathology
MH  - Nerve Regeneration/physiology
OTO - NOTNLM
OT  - Axonal degeneration
OT  - Demyelination
OT  - Parthenolide
OT  - Perpheral nerve
OT  - Schwann cell
EDAT- 2023/04/07 06:00
MHDA- 2023/10/23 00:42
CRDT- 2023/04/06 23:24
PHST- 2023/01/17 00:00 [received]
PHST- 2023/03/15 00:00 [accepted]
PHST- 2023/10/23 00:42 [medline]
PHST- 2023/04/07 06:00 [pubmed]
PHST- 2023/04/06 23:24 [entrez]
AID - 10.1007/s12565-023-00718-6 [pii]
AID - 10.1007/s12565-023-00718-6 [doi]
PST - ppublish
SO  - Anat Sci Int. 2023 Sep;98(4):529-539. doi: 10.1007/s12565-023-00718-6. Epub 2023 
      Apr 6.