PMID- 37026297
OWN - NLM
STAT- MEDLINE
DCOM- 20230508
LR  - 20230619
IS  - 1998-3689 (Electronic)
IS  - 0301-4738 (Print)
IS  - 0301-4738 (Linking)
VI  - 71
IP  - 4
DP  - 2023 Apr
TI  - Dry eye disease and risk factors for corneal complications in chronic ocular 
      graft-versus-host disease.
PG  - 1538-1544
LID - 10.4103/IJO.IJO_2820_22 [doi]
AB  - PURPOSE: The current study was carried out to evaluate the clinical features and 
      management outcomes of dry eye disease (DED) in chronic ocular GvHD following 
      allogenic hematopoietic stem cell transplantation (HSCT). METHODS: A 
      retrospective review of consecutive patients diagnosed with chronic ocular GvHD 
      between 2011 and 2020 was performed at a tertiary eye care network. Multi-variate 
      regression analysis was carried out for identifying risk factors associated with 
      progressive disease. RESULTS: A total of 34 patients (68 eyes) with a median age 
      of 33 years [inter-quartile range (IQR) 23-40.5] were studied. The most common 
      indication for HSCT was acute lymphocytic leukemia (26%). Ocular GvHD developed 
      at a median of 2 years (IQR 1-5.5 years) after HSCT. Aqueous tear deficiency was 
      present in 71% of the eyes, of which 84% had a Schirmer value of <5 mm. The 
      median visual acuity at presentation and that after a median follow-up of 6.9 
      months were comparable at 0.1 log minimum angle of resolution (logMAR) (P = 
      0.97). Topical immunosuppression was required in 88% of cases, and with this, 
      improvement in corneal (53%, P = 0.003) and conjunctival staining scores (45%, P 
      = 0.43) was noted. A progressive disease was present in 32% with persistent 
      epithelial defects being the most common complication. Grade 2 conjunctival 
      hyperemia [odds ratio (OR): 2.6; P = 0.01] and Schirmer's value <5 mm (OR: 2.7; P 
      = 0.03) were found to be associated with progressive disease. CONCLUSION: Aqueous 
      deficient DED is the most common ocular manifestation of chronic ocular GvHD, and 
      the risk of the disease progression is greater in eyes with conjunctival 
      hyperemia and severe aqueous deficiency. Awareness among ophthalmologists of this 
      entity is essential for its timely detection and optimal management.
FAU - Kate, Anahita
AU  - Kate A
AD  - Shantilal Shanghvi Cornea Institue, LV Prasad Eye Institute, Vijayawada, Andhra 
      Pradesh, India.
FAU - Singh, Swati
AU  - Singh S
AD  - Ophthalmic Plastic Surgery Services, LV Prasad Eye Institute, Hyderabad, 
      Telangana, India.
FAU - Das, Anthony Vipin
AU  - Das AV
AD  - Department of EyeSmart EMR and AEye, LV Prasad Eye Institute, Hyderabad, 
      Telangana, India.
FAU - Basu, Sayan
AU  - Basu S
AD  - Shantilal Shanghvi Cornea Institue, LV Prasad Eye Institute; Center for Ocular 
      Regeneration (CORE); Brien Holden Eye Research Centre, L V Prasad Eye Institute, 
      Hyderabad, Telangana, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Ophthalmol
JT  - Indian journal of ophthalmology
JID - 0405376
SB  - IM
CIN - Indian J Ophthalmol. 2023 Apr;71(4):1545. PMID: 37026298
MH  - *Dry Eye Syndromes/epidemiology/etiology
MH  - *Graft vs Host Disease/complications
MH  - *Hyperemia/complications
MH  - Risk Factors
MH  - Allografts
MH  - Hematopoietic Stem Cell Transplantation/adverse effects
PMC - PMC10276705
OTO - NOTNLM
OT  - Chronic GvHD
OT  - dry eye disease
OT  - graft-versus-host disease
OT  - ocular GvHD
OT  - progression
OT  - risk factors
COIS- None
EDAT- 2023/04/08 06:00
MHDA- 2023/04/10 06:42
PMCR- 2023/04/01
CRDT- 2023/04/07 03:15
PHST- 2023/04/10 06:42 [medline]
PHST- 2023/04/07 03:15 [entrez]
PHST- 2023/04/08 06:00 [pubmed]
PHST- 2023/04/01 00:00 [pmc-release]
AID - IndianJOphthalmol_2023_71_4_1538_373489 [pii]
AID - IJO-71-1538 [pii]
AID - 10.4103/IJO.IJO_2820_22 [doi]
PST - ppublish
SO  - Indian J Ophthalmol. 2023 Apr;71(4):1538-1544. doi: 10.4103/IJO.IJO_2820_22.