PMID- 37026902
OWN - NLM
STAT- MEDLINE
DCOM- 20230411
LR  - 20230508
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 102
IP  - 14
DP  - 2023 Apr 7
TI  - Role and mechanism of actin-related protein 2/3 complex signaling in cancer 
      invasion and metastasis: A review.
PG  - e33158
LID - 10.1097/MD.0000000000033158 [doi]
LID - e33158
AB  - The actin 2/3 complex (Arp2/3) regulates actin polymerization and nucleation of 
      actin filaments, is associated with cell motility, and has been shown to play a 
      key role in the invasion and migration of cancer cells. nucleation-promoting 
      factor (NPF) such as N-WASP (neural-WASP famly verprolin-homologous protein 
      family), WAVE (WASP famly verprolin-homologous protein family), and WASH (WASP 
      and Scar homologue) undergo conformational changes upon receipt of multiple 
      upstream signals including Rho family GTPases, cdc42 (Cell division control 
      protein 42 homolog), and phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5 P2) to 
      bind and activate the Arp2/3 complex. Once activated, the Arp2/3 complex forms 
      actin-based membrane protrusions necessary for cancer cells to acquire an 
      invasive phenotype. Therefore, how to influence the invasion and migration of 
      cancer cells by regulating the activity of the Arp2/3 complex has attracted great 
      research interest in recent years. Several studies have explored the effects of 
      phosphorylation modifications of cortactin and several NPFs (Nucleation Promoting 
      Factor) including N-WASP and WAVE on the activity of the Arp2/3 complex and 
      ultimately on cancer cell invasiveness, and have attempted to suggest new 
      strategies for antiinvasive therapy as a result. Other studies have highlighted 
      the potential of targeting genes encoding partial or complete proteins of the 
      Arp2/3 complex as a therapeutic strategy to prevent cancer cell invasion and 
      metastasis. This article reviews the role of the Arp2/3 complex in the 
      development, invasion, and metastasis of different types of cancer and the 
      mechanisms regulating the activity of the Arp2/3 complex.
CI  - Copyright (c) 2023 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Zheng, Sihan
AU  - Zheng S
AD  - Department of Otorhinolaryngology, The Affiliated Traditional Chinese Medicine 
      Hospital of Southwest Medical University, Luzhou, China.
FAU - Qin, Fengfeng
AU  - Qin F
AD  - Department of Otorhinolaryngology, The Affiliated Traditional Chinese Medicine 
      Hospital of Southwest Medical University, Luzhou, China.
FAU - Yin, Ji
AU  - Yin J
AD  - Department of Otorhinolaryngology, The Affiliated Traditional Chinese Medicine 
      Hospital of Southwest Medical University, Luzhou, China.
FAU - Li, Daiying
AU  - Li D
AD  - Department of Otorhinolaryngology, The Affiliated Traditional Chinese Medicine 
      Hospital of Southwest Medical University, Luzhou, China.
FAU - Huang, Yanlin
AU  - Huang Y
AD  - Department of Otorhinolaryngology, The Affiliated Traditional Chinese Medicine 
      Hospital of Southwest Medical University, Luzhou, China.
FAU - Hu, Lanxin
AU  - Hu L
AD  - Department of Otorhinolaryngology, The Affiliated Traditional Chinese Medicine 
      Hospital of Southwest Medical University, Luzhou, China.
FAU - He, Lu
AU  - He L
AD  - Department of Otorhinolaryngology, The Affiliated Traditional Chinese Medicine 
      Hospital of Southwest Medical University, Luzhou, China.
FAU - Lv, Caifeng
AU  - Lv C
AD  - Department of Otorhinolaryngology, The Affiliated Traditional Chinese Medicine 
      Hospital of Southwest Medical University, Luzhou, China.
FAU - Li, Xiaohui
AU  - Li X
AD  - Department of Otorhinolaryngology, The Affiliated Traditional Chinese Medicine 
      Hospital of Southwest Medical University, Luzhou, China.
FAU - Li, Sen
AU  - Li S
AD  - Spinal Surgery Department, the Affiliated Traditional Chinese Medicine Hospital 
      of Southwest Medical University, Luzhou, China.
FAU - Hu, Wenjian
AU  - Hu W
AUID- ORCID: 0000-0002-0580-4732
AD  - Department of Otorhinolaryngology, The Affiliated Traditional Chinese Medicine 
      Hospital of Southwest Medical University, Luzhou, China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Actin-Related Protein 2-3 Complex)
RN  - 0 (Actins)
RN  - 0 (Actin-Related Protein 2)
RN  - 0 (Actin-Related Protein 3)
RN  - 0 (Wiskott-Aldrich Syndrome Protein Family)
SB  - IM
MH  - *Actin-Related Protein 2-3 Complex/metabolism
MH  - Actins/metabolism
MH  - Actin-Related Protein 2
MH  - Actin-Related Protein 3
MH  - Wiskott-Aldrich Syndrome Protein Family/metabolism
MH  - *Neoplasms
PMC - PMC10082322
COIS- The authors have no funding and conflicts of interest to disclose.
EDAT- 2023/04/08 06:00
MHDA- 2023/04/11 06:42
PMCR- 2022/04/07
CRDT- 2023/04/07 10:12
PHST- 2023/04/11 06:42 [medline]
PHST- 2023/04/07 10:12 [entrez]
PHST- 2023/04/08 06:00 [pubmed]
PHST- 2022/04/07 00:00 [pmc-release]
AID - 00005792-202304070-00003 [pii]
AID - 10.1097/MD.0000000000033158 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2023 Apr 7;102(14):e33158. doi: 
      10.1097/MD.0000000000033158.