PMID- 37028205 OWN - NLM STAT- MEDLINE DCOM- 20230515 LR - 20240502 IS - 1573-2509 (Electronic) IS - 0920-9964 (Print) IS - 0920-9964 (Linking) VI - 255 DP - 2023 May TI - Sampling from different populations: Sociodemographic, clinical, and functional differences between samples of first episode psychosis individuals and clinical high-risk individuals who progressed to psychosis. PG - 239-245 LID - S0920-9964(23)00141-X [pii] LID - 10.1016/j.schres.2023.03.047 [doi] AB - Over the past two decades, research and clinical resources on clinical high risk (CHR) for psychosis have both expanded, with goals to better understanding risk and protective factors on the course of illness and inform early intervention efforts. However, some studies have highlighted potential sampling bias among CHR research studies, raising questions about generalizability of findings and inequitable access to early detection and intervention. The current study sought to explore these questions by comparing 94 participants in a CHR longitudinal monitoring study across North America (NAPLS-2) who converted to syndromal psychosis over the course of the study (CHR-CV) to 171 participants who presented for treatment at a localized first-episode psychosis service (FES) after converting. CHR-CV participants were significantly more likely to be White and have a college-educated parent, while FES participants were more likely to be Black and first- or second-generation immigrants. On average, CHR-CV participants were younger at onset of attenuated positive symptoms, had a longer period of attenuated symptoms prior to conversion, and were more likely to be treated with antipsychotics prior to conversion compared to those in FES programs. After controlling for time since conversion, CHR-CV participants had higher global functioning and were less likely to have experienced recent psychiatric hospitalization. Findings suggest that CHR research and FES clinics may be sampling from different populations, although conclusions are limited by inconsistent sampling frames and methods. Integrated early detection that targets defined geographic catchments may deliver more epidemiologically representative samples to both CHR research and FES. CI - Copyright (c) 2023 Elsevier B.V. All rights reserved. FAU - Hagler, Matthew A AU - Hagler MA AD - Department of Psychiatry, Yale University, New Haven, CT, United States of America. Electronic address: Matthew.Hagler@fmarion.edu. FAU - Ferrara, Maria AU - Ferrara M AD - Department of Psychiatry, Yale University, New Haven, CT, United States of America; Institute of Psychiatry, Department of Neurosciences and Rehabilitation, University of Ferrara, Ferrara, Italy. FAU - Yoviene Sykes, Laura A AU - Yoviene Sykes LA AD - Department of Psychiatry, Yale University, New Haven, CT, United States of America. FAU - Li, Fangyong AU - Li F AD - Department of Psychiatry, Yale University, New Haven, CT, United States of America. FAU - Addington, Jean AU - Addington J AD - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada. FAU - Bearden, Carrie E AU - Bearden CE AD - Departments of Psychology and Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, United States of America. FAU - Cadenhead, Kristin S AU - Cadenhead KS AD - Department of Psychiatry, UCSD, San Diego, CA, United States of America. FAU - Cannon, Tyrone D AU - Cannon TD AD - Departments of Psychology and Psychiatry, Yale University, New Haven, CT, United States of America. FAU - Cornblatt, Barbara A AU - Cornblatt BA AD - Department of Psychiatry, Zucker Hillside Hospital, Long Island, NY, United States of America. FAU - Perkins, Diana O AU - Perkins DO AD - Department of Psychiatry, University of North Carolina, Chapel Hill, NC, United States of America. FAU - Mathalon, Daniel H AU - Mathalon DH AD - Department of Psychiatry, UCSF, San Francisco, CA, United States of America. FAU - Seidman, Larry J AU - Seidman LJ AD - Department of Psychiatry, Harvard Medical School, Boston, MA, United States of America. FAU - Tsuang, Ming T AU - Tsuang MT AD - Department of Psychiatry, UCSD, San Diego, CA, United States of America. FAU - Walker, Elaine F AU - Walker EF AD - Departments of Psychology and Psychiatry, Emory University, Atlanta, GA, United States of America. FAU - Powers, Albert R 3rd AU - Powers AR 3rd AD - Department of Psychiatry, Yale University, New Haven, CT, United States of America. FAU - Allen, Adrienne R AU - Allen AR AD - Department of Psychiatry, Yale University, New Haven, CT, United States of America. FAU - Srihari, Vinod H AU - Srihari VH AD - Department of Psychiatry, Yale University, New Haven, CT, United States of America. FAU - Woods, Scott W AU - Woods SW AD - Department of Psychiatry, Yale University, New Haven, CT, United States of America. LA - eng GR - UL1 TR001863/TR/NCATS NIH HHS/United States GR - U01 MH081902/MH/NIMH NIH HHS/United States GR - P50 MH080272/MH/NIMH NIH HHS/United States GR - U01 MH081988/MH/NIMH NIH HHS/United States GR - P50 MH066286/MH/NIMH NIH HHS/United States GR - R01 MH103831/MH/NIMH NIH HHS/United States GR - K24 MH076191/MH/NIMH NIH HHS/United States GR - U01 MH082022/MH/NIMH NIH HHS/United States GR - U01 MH081984/MH/NIMH NIH HHS/United States GR - R01 MH060720/MH/NIMH NIH HHS/United States GR - U01 MH081928/MH/NIMH NIH HHS/United States GR - U01 MH081857/MH/NIMH NIH HHS/United States GR - U01 MH082004/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20230406 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 SB - IM MH - Humans MH - *Psychotic Disorders/psychology MH - Longitudinal Studies MH - Protective Factors MH - North America MH - Prodromal Symptoms PMC - PMC10207144 MID - NIHMS1889704 OTO - NOTNLM OT - Clinical high risk OT - Conversion OT - Early detection OT - First episode OT - Sampling bias COIS- Declaration of competing interest We have no conflicts of interest to declare. EDAT- 2023/04/08 06:00 MHDA- 2023/05/15 06:42 PMCR- 2024/05/01 CRDT- 2023/04/07 18:11 PHST- 2022/08/26 00:00 [received] PHST- 2023/02/24 00:00 [revised] PHST- 2023/03/29 00:00 [accepted] PHST- 2023/05/15 06:42 [medline] PHST- 2023/04/08 06:00 [pubmed] PHST- 2023/04/07 18:11 [entrez] PHST- 2024/05/01 00:00 [pmc-release] AID - S0920-9964(23)00141-X [pii] AID - 10.1016/j.schres.2023.03.047 [doi] PST - ppublish SO - Schizophr Res. 2023 May;255:239-245. doi: 10.1016/j.schres.2023.03.047. Epub 2023 Apr 6.