PMID- 37029358
OWN - NLM
STAT- MEDLINE
DCOM- 20230411
LR  - 20230412
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 23
IP  - 1
DP  - 2023 Apr 7
TI  - Does chronic low-dose aspirin use benefit bone health? A cross-sectional study on 
      patients with type 2 diabetes mellitus.
PG  - 79
LID - 10.1186/s12902-023-01309-2 [doi]
LID - 79
AB  - INTRODUCTION: Numerous studies have reported the striking result that aspirin use 
      is associated with higher bone mineral density (BMD), suggesting its potential as 
      a population-wide osteoporosis prevention measure. Therefore, this study aimed to 
      examine the impact of chronic low-dose aspirin use on bone remodeling biomarkers 
      and BMD in an aging population. MATERIALS AND METHODS: Between September and 
      November of 2019, clinical data regarding the medication use, serum bone 
      remodeling biomarkers, and BMD of 567 consecutively hospitalized patients, a 
      minimum of 50 years old with type 2 diabetes mellitus (T2DM), were collected. The 
      cross-sectional associations between chronic low-dose aspirin use and serum 
      concentrations of bone remodeling biomarkers and BMD were estimated separately 
      using linear regression. Potential confounding variables were controlled for, 
      including age, sex, and comorbidities. RESULTS: Low-dose aspirin users had 
      significantly lower serum bone alkaline phosphatase (BAP) concentrations than 
      non-users (82.44 +/- 28.03 U/L vs 90.71 +/- 32.79 U/L, p = 0.025). On the other hand, 
      low-dose aspirin users had insignificantly higher vertebral BMD (0.95 +/- 0.19 vs 
      0.91 +/- 0.21, p = 0.185), femoral neck BMD (0.80 +/- 0.15 vs 0.78 +/- 0.17, p = 0.309) 
      and Ward's triangle BMD (0.46 +/- 0.14 vs 0.44 +/- 0.13, p = 0.209), regardless of 
      adjustment. CONCLUSIONS: This cross-sectional study demonstrated that chronic use 
      of low-dose aspirin was associated with significantly lower serum concentrations 
      of BAP in hospitalized patients with T2DM. The mechanism causing the 
      insignificantly higher BMD observed in chronic aspirin users in this study and 
      the significant increments in BMD reported in previous studies requires further 
      clarification in other clinical trials.
CI  - (c) 2023. The Author(s).
FAU - Zhang, Li
AU  - Zhang L
AD  - Department of Geriatrics, the Second People' Hospital of Wuhu, Anhui, 230032, 
      China.
FAU - Ji, Xuelei
AU  - Ji X
AD  - Department of Endocrinology, the Second People' Hospital of Wuhu, Anhui, 230032, 
      China.
FAU - Chen, Jun
AU  - Chen J
AD  - Department of Endocrinology, the Second People' Hospital of Wuhu, Anhui, 230032, 
      China.
FAU - Zhu, Yu
AU  - Zhu Y
AD  - School of Basic Medical Science, and the, First Clinical Medical College, Anhui 
      Medical University, 81# Mei Shan Road, Hefei, 230032, Anhui, China.
FAU - Wang, Zhen
AU  - Wang Z
AD  - Department of Trauma and Spine Surgery, the Second People' Hospital of Wuhu, 
      Anhui, 230032, China.
FAU - Ma, Zhen
AU  - Ma Z
AD  - Department of Trauma and Spine Surgery, the Second People' Hospital of Wuhu, 
      Anhui, 230032, China.
FAU - Wu, Yu
AU  - Wu Y
AD  - Department of Trauma and Spine Surgery, the Second People' Hospital of Wuhu, 
      Anhui, 230032, China.
FAU - Wu, Faguo
AU  - Wu F
AD  - Department of Geriatrics, the Second People' Hospital of Wuhu, Anhui, 230032, 
      China.
FAU - Zheng, Zhangan
AU  - Zheng Z
AD  - Department of Trauma and Spine Surgery, the Second People' Hospital of Wuhu, 
      Anhui, 230032, China. 114934833@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20230407
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
RN  - R16CO5Y76E (Aspirin)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - Aged
MH  - Middle Aged
MH  - *Bone Density
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Aspirin/therapeutic use
MH  - Biomarkers
MH  - Absorptiometry, Photon
PMC - PMC10080941
OTO - NOTNLM
OT  - Aspirin
OT  - Bone
OT  - Cyclo-oxygenase
OT  - Nonsteroidal anti-inflammatory drugs
OT  - Osteoporosis
COIS- Li Zhang, Xuelei Ji, Jun Chen, Yu Zhu, Zhen Wang, Zhen Ma, Yu Wu, Faguo Wu and 
      Zhangan Zheng declare that they have no competing interests.
EDAT- 2023/04/08 06:00
MHDA- 2023/04/11 06:42
PMCR- 2023/04/07
CRDT- 2023/04/07 23:33
PHST- 2022/08/15 00:00 [received]
PHST- 2023/02/28 00:00 [accepted]
PHST- 2023/04/11 06:42 [medline]
PHST- 2023/04/07 23:33 [entrez]
PHST- 2023/04/08 06:00 [pubmed]
PHST- 2023/04/07 00:00 [pmc-release]
AID - 10.1186/s12902-023-01309-2 [pii]
AID - 1309 [pii]
AID - 10.1186/s12902-023-01309-2 [doi]
PST - epublish
SO  - BMC Endocr Disord. 2023 Apr 7;23(1):79. doi: 10.1186/s12902-023-01309-2.