PMID- 37030130
OWN - NLM
STAT- MEDLINE
DCOM- 20230612
LR  - 20230711
IS  - 1532-818X (Electronic)
IS  - 0196-0709 (Print)
IS  - 0196-0709 (Linking)
VI  - 44
IP  - 4
DP  - 2023 Jul-Aug
TI  - Hearing outcomes in children with pneumococcal meningitis in the PCV13 era.
PG  - 103886
LID - S0196-0709(23)00100-X [pii]
LID - 10.1016/j.amjoto.2023.103886 [doi]
AB  - INTRODUCTION: Streptococcus pneumoniae, is associated with the highest incidence 
      of post-meningitic SNHL. The exact impact of 13-valent pneumococcal conjugate 
      vaccine (PCV) on pediatric SNHL from pneumococcal meningitis is unknown. We aimed 
      to identify clinical factors associated with post-meningitic SNHL (pmSNHL) from 
      pneumococcal meningitis and describe its rates based on three time periods: 
      pre-PCV, PCV-7 and PCV13 eras. METHODS: A retrospective case-control study was 
      performed for patients 18 years and younger diagnosed with pneumococcal 
      meningitis from January 1, 2010 to December 31, 2020 at Children's Hospital 
      Colorado. Demographic and clinical risk factors between those with or without 
      SNHL were compared. Detailed hearing outcomes of those with resulting SNHL are 
      described. RESULTS: 23 patients with CSF cultures or Meningitis/Encephalitis 
      Panel positive for pneumococcal meningitis were identified. Twenty patients both 
      survived the infection and had audiologic evaluation. Six patients had pmSNHL, 
      with 50 % affected bilaterally. The rate of pmSNHL from S. pneumoniae in the 
      PCV-13 era at our institution was similar to historical rates from the pre-PCV 
      and PCV-7 eras. Similar proportions of patients with pmSNHL completed PCV 
      vaccination (66.7 %) compared to those without (71.4 %). Non-PCV-13 serotypes 
      were responsible 83 % of patients with pmSNHL versus 57 % of patients without 
      pmSNHL. CONCLUSIONS: Despite high rates of PCV-13 uptake in our cohort, pmSNHL 
      was still common, severe, and commonly associated with non-PCV-13 serotypes. 
      Non-PCV-13 serotypes may be contributing to the persistently high rate of 
      post-meningitic SNHL and the severity of SNHL. Newer pneumococcal conjugate 
      vaccines with expanded serotypes may help mitigate the SNHL associated with 
      pneumococcal meningitis.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Lee, Nam K
AU  - Lee NK
AD  - University of Colorado Anschutz School of Medicine, Aurora, CO 80045, USA. 
      Electronic address: nam.lee@cuanschutz.edu.
FAU - Tong, Suhong
AU  - Tong S
AD  - Center for Research Outcomes in Children's Surgery, Center for Children's 
      Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
FAU - Tholen, Kaitlyn
AU  - Tholen K
AD  - Children's Hospital of Colorado (CHCO), Anschutz Medical Campus, Department of 
      Otolaryngology-Pediatric, Aurora, CO 80045, USA.
FAU - Boguniewicz, Juri
AU  - Boguniewicz J
AD  - University of Colorado Anschutz School of Medicine, Aurora, CO 80045, USA; 
      Children's Hospital of Colorado (CHCO), Anschutz Medical Campus (CHCO), 
      Department of Infectious Disease-Pediatrics, Aurora, CO 80045, USA.
FAU - Gitomer, Sarah A
AU  - Gitomer SA
AD  - University of Colorado Anschutz School of Medicine, Aurora, CO 80045, USA; 
      Children's Hospital of Colorado (CHCO), Anschutz Medical Campus, Department of 
      Otolaryngology-Pediatric, Aurora, CO 80045, USA.
FAU - Herrmann, Brian W
AU  - Herrmann BW
AD  - University of Colorado Anschutz School of Medicine, Aurora, CO 80045, USA; 
      Children's Hospital of Colorado (CHCO), Anschutz Medical Campus, Department of 
      Otolaryngology-Pediatric, Aurora, CO 80045, USA.
LA  - eng
GR  - UL1 TR002535/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20230405
PL  - United States
TA  - Am J Otolaryngol
JT  - American journal of otolaryngology
JID - 8000029
RN  - 0 (Pneumococcal Vaccines)
RN  - 0 (Vaccines, Conjugate)
SB  - IM
MH  - Child
MH  - Humans
MH  - Infant
MH  - *Meningitis, Pneumococcal/complications/epidemiology/prevention & control
MH  - Retrospective Studies
MH  - Case-Control Studies
MH  - Streptococcus pneumoniae
MH  - Pneumococcal Vaccines
MH  - Hearing
MH  - Vaccines, Conjugate
PMC - PMC10330152
MID - NIHMS1890090
OTO - NOTNLM
OT  - Meningitis sequalae
OT  - PCV13
OT  - Pneumococcal meningitis
OT  - Post-meningitic sensorineural hearing loss
OT  - Sensorineural hearing loss
COIS- Conflict of interest The authors declare that the research was conducted in the 
      absence of any commercial or financial relationships that could be construed as a 
      potential conflict of interest.
EDAT- 2023/04/09 06:00
MHDA- 2023/06/12 06:42
PMCR- 2024/07/01
CRDT- 2023/04/08 18:06
PHST- 2023/03/22 00:00 [received]
PHST- 2023/04/01 00:00 [accepted]
PHST- 2024/07/01 00:00 [pmc-release]
PHST- 2023/06/12 06:42 [medline]
PHST- 2023/04/09 06:00 [pubmed]
PHST- 2023/04/08 18:06 [entrez]
AID - S0196-0709(23)00100-X [pii]
AID - 10.1016/j.amjoto.2023.103886 [doi]
PST - ppublish
SO  - Am J Otolaryngol. 2023 Jul-Aug;44(4):103886. doi: 10.1016/j.amjoto.2023.103886. 
      Epub 2023 Apr 5.