PMID- 37031915
OWN - NLM
STAT- MEDLINE
DCOM- 20230428
LR  - 20230502
IS  - 1872-7980 (Electronic)
IS  - 0304-3835 (Linking)
VI  - 562
DP  - 2023 May 28
TI  - Dendritic cell-derived exosomes: A new horizon in personalized cancer 
      immunotherapy?
PG  - 216168
LID - S0304-3835(23)00119-2 [pii]
LID - 10.1016/j.canlet.2023.216168 [doi]
AB  - Dendritic cells (DCs) release nanometer-sized membrane vesicles known as 
      dexosomes, containing different molecules, particularly proteins, for presenting 
      antigens, i.e., major histocompatibility complex (MHC)-I/II and CD86. Dexosomes 
      can, directly and indirectly, stimulate antigen-reactive CD8(+) and CD4(+) T cell 
      responses. Antigen-loaded dexosomes can lead to the development of potent 
      anti-tumoral immune responses. Notably, developing dexosome-based cell-free 
      vaccines could serve as a new vaccination platform in the era of immunotherapy 
      for various cancers. Furthermore, combining dexosomes vaccination strategies with 
      other treatment approaches can considerably increase tumor-specific T cell 
      responses. Herein, we aimed to review how dexosomes interact with immune cells, 
      e.g., CD4(+) and CD8(+) T cells and natural killer (NK) cells. Besides, we 
      discussed the limitations of this approach and suggested potential strategies to 
      improve its effectiveness for affected patients.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Ghorbaninezhad, Farid
AU  - Ghorbaninezhad F
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; 
      Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Alemohammad, Hajar
AU  - Alemohammad H
AD  - Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, 
      Iran.
FAU - Najafzadeh, Basira
AU  - Najafzadeh B
AD  - Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, 
      Iran.
FAU - Masoumi, Javad
AU  - Masoumi J
AD  - Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Shadbad, Mahdi Abdoli
AU  - Shadbad MA
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Shahpouri, Mohammad
AU  - Shahpouri M
AD  - Department of Medical Biotechnology, School of Advanced Medical Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Saeedi, Hossein
AU  - Saeedi H
AD  - Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Rahbarfarzam, Omid
AU  - Rahbarfarzam O
AD  - Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Baradaran, Behzad
AU  - Baradaran B
AD  - Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; 
      Department of Immunology, Faculty of Medicine, Tabriz University of Medical 
      Sciences, Tabriz, Iran. Electronic address: baradaranb@tbzmed.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230407
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Humans
MH  - *Exosomes
MH  - CD8-Positive T-Lymphocytes
MH  - Dendritic Cells
MH  - *Neoplasms/therapy/metabolism
MH  - Immunotherapy
MH  - *Cancer Vaccines/therapeutic use
OTO - NOTNLM
OT  - CD4(+) T cells
OT  - CD8(+) T cells
OT  - Cancer immunotherapy
OT  - Dendritic cells
OT  - Dexosomes
OT  - NK cells
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/04/10 06:00
MHDA- 2023/04/28 06:41
CRDT- 2023/04/09 19:26
PHST- 2023/01/20 00:00 [received]
PHST- 2023/03/25 00:00 [revised]
PHST- 2023/04/03 00:00 [accepted]
PHST- 2023/04/28 06:41 [medline]
PHST- 2023/04/10 06:00 [pubmed]
PHST- 2023/04/09 19:26 [entrez]
AID - S0304-3835(23)00119-2 [pii]
AID - 10.1016/j.canlet.2023.216168 [doi]
PST - ppublish
SO  - Cancer Lett. 2023 May 28;562:216168. doi: 10.1016/j.canlet.2023.216168. Epub 2023 
      Apr 7.