PMID- 37032278
OWN - NLM
STAT- MEDLINE
DCOM- 20231201
LR  - 20231204
IS  - 1878-4046 (Electronic)
IS  - 1076-6332 (Linking)
VI  - 30
IP  - 12
DP  - 2023 Dec
TI  - (129)Xe MRI Ventilation Defects in Asthma: What is the Upper Limit of Normal and 
      Minimal Clinically Important Difference?
PG  - 3114-3123
LID - S1076-6332(23)00121-6 [pii]
LID - 10.1016/j.acra.2023.03.010 [doi]
AB  - RATIONALE AND OBJECTIVES: The minimal clinically important difference (MCID) and 
      upper limit of normal (ULN) for MRI ventilation defect percent (VDP) were 
      previously reported for hyperpolarized (3)He gas MRI. Hyperpolarized (129)Xe VDP 
      is more sensitive to airway dysfunction than (3)He, therefore the objective of 
      this study was to determine the ULN and MCID for (129)Xe MRI VDP in healthy and 
      asthma participants. MATERIALS AND METHODS: We retrospectively evaluated healthy 
      and asthma participants who underwent spirometry and (129)XeMRI on a single 
      visit; participants with asthma completed the asthma control questionnaire 
      (ACQ-7). The MCID was estimated using distribution- (smallest detectable 
      difference [SDD]) and anchor-based (ACQ-7) methods. Two observers measured VDP 
      (semiautomated k-means-cluster segmentation algorithm) in 10 participants with 
      asthma, five-times each in random order, to determine SDD. The ULN was estimated 
      based on the 95% confidence interval of the relationships between VDP and age. 
      RESULTS: Mean VDP was 1.6 +/- 1.2% for healthy (n = 27) and 13.7 +/- 12.9% for asthma 
      participants (n = 55). ACQ-7 and VDP were correlated (r = .37, p = .006; 
      VDP = 3.5.ACQ + 4.9). The anchor-based MCID was 1.75% while the mean SDD and 
      distribution-based MCID was 2.25%. VDP was correlated with age for healthy 
      participants (p = .56, p =.003; VDP = .04.Age-.01). The ULN for all healthy 
      participants was 2.0%. By age tertiles, the ULN was 1.3% ages 18-39 years, 2.5% 
      for 40-59 years and 3.8% for 60-79 years. CONCLUSION: The (129)Xe MRI VDP MCID 
      was estimated in participants with asthma; the ULN was estimated in healthy 
      participants across a range of ages, both of which provide a way to interpret VDP 
      measurements in clinical investigations.
CI  - Copyright (c) 2023 The Association of University Radiologists. Published by 
      Elsevier Inc. All rights reserved.
FAU - McIntosh, Marrissa J
AU  - McIntosh MJ
AD  - Robarts Research Institute, Western University, London, Canada; Department of 
      Medical Biophysics, Western University, London, Canada.
FAU - Biancaniello, Alexander
AU  - Biancaniello A
AD  - Robarts Research Institute, Western University, London, Canada; Department of 
      Medical Biophysics, Western University, London, Canada.
FAU - Kooner, Harkiran K
AU  - Kooner HK
AD  - Robarts Research Institute, Western University, London, Canada; Department of 
      Medical Biophysics, Western University, London, Canada.
FAU - Bhalla, Anurag
AU  - Bhalla A
AD  - Division of Respirology, Department of Medicine, Western University, London, 
      Canada.
FAU - Serajeddini, Hana
AU  - Serajeddini H
AD  - Robarts Research Institute, Western University, London, Canada; Division of 
      Respirology, Department of Medicine, Western University, London, Canada.
FAU - Yamashita, Cory
AU  - Yamashita C
AD  - Division of Respirology, Department of Medicine, Western University, London, 
      Canada.
FAU - Parraga, Grace
AU  - Parraga G
AD  - Robarts Research Institute, Western University, London, Canada; Department of 
      Medical Biophysics, Western University, London, Canada; Division of Respirology, 
      Department of Medicine, Western University, London, Canada. Electronic address: 
      gparraga@uwo.ca.
FAU - Eddy, Rachel L
AU  - Eddy RL
AD  - Centre for Heart Lung Innovation, St. Paul's Hospital and University of British 
      Columbia, Vancouver, Canada.
LA  - eng
PT  - Journal Article
DEP - 20230408
PL  - United States
TA  - Acad Radiol
JT  - Academic radiology
JID - 9440159
SB  - IM
MH  - Humans
MH  - Infant
MH  - Adolescent
MH  - Young Adult
MH  - Adult
MH  - *Lung
MH  - Retrospective Studies
MH  - Minimal Clinically Important Difference
MH  - *Asthma/diagnostic imaging
MH  - Magnetic Resonance Imaging/methods
OTO - NOTNLM
OT  - Asthma
OT  - MRI
OT  - Minimal clinically important difference
OT  - Smallest detectable difference
OT  - Upper limit of normal
OT  - Ventilation defects
COIS- Declaration of Competing Interest None.
EDAT- 2023/04/10 06:00
MHDA- 2023/12/01 06:44
CRDT- 2023/04/09 22:03
PHST- 2023/02/05 00:00 [received]
PHST- 2023/03/09 00:00 [revised]
PHST- 2023/03/09 00:00 [accepted]
PHST- 2023/12/01 06:44 [medline]
PHST- 2023/04/10 06:00 [pubmed]
PHST- 2023/04/09 22:03 [entrez]
AID - S1076-6332(23)00121-6 [pii]
AID - 10.1016/j.acra.2023.03.010 [doi]
PST - ppublish
SO  - Acad Radiol. 2023 Dec;30(12):3114-3123. doi: 10.1016/j.acra.2023.03.010. Epub 
      2023 Apr 8.