PMID- 37032731
OWN - NLM
STAT- MEDLINE
DCOM- 20230411
LR  - 20230412
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 29
IP  - 12
DP  - 2023 Mar 28
TI  - Mitochondrial carnitine palmitoyltransferase-II dysfunction: A possible novel 
      mechanism for nonalcoholic fatty liver disease in hepatocarcinogenesis.
PG  - 1765-1778
LID - 10.3748/wjg.v29.i12.1765 [doi]
AB  - Nonalcoholic fatty liver disease (NAFLD) or metabolic-associated fatty liver 
      disease has been characterized by the lipid accumulation with injury of 
      hepatocytes and has become one of the most common chronic liver diseases in the 
      world. The complex mechanisms of NAFLD formation are still under identification. 
      Carnitine palmitoyltransferase-II (CPT-II) on inner mitochondrial membrane (IMM) 
      regulates long chain fatty acid beta-oxidation, and its abnormality has had more and 
      more attention paid to it by basic and clinical research in NAFLD. The sequences 
      of its peptide chain and DNA nucleotides have been identified, and the catalytic 
      activity of CPT-II is affected on its gene mutations, deficiency, enzymatic 
      thermal instability, circulating carnitine level and so on. Recently, the CPT-II 
      dysfunction has been discovered in models of liver lipid accumulation. Meanwhile, 
      the malignant transformation of hepatocyte-related CD44(+) stem T cell 
      activation, high levels of tumor-related biomarkers (AFP, GPC3) and abnormal 
      activation of Wnt3a expression as a key signal molecule of the Wnt/beta-catenin 
      pathway run parallel to the alterations of hepatocyte pathology. This review 
      focuses on some of the progress of CPT-II inactivity on IMM with liver fatty 
      accumulation as a possible novel pathogenesis for NAFLD in hepatocarcinogenesis.
CI  - (c)The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Yao, Min
AU  - Yao M
AD  - Department of Medical Immunology, Medical School of Nantong University & Research 
      Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong 
      226001, Jiangsu Province, China.
FAU - Zhou, Ping
AU  - Zhou P
AD  - Department of Medical Immunology, Medical School of Nantong University, Nantong 
      226001, Jiangsu Province, China.
FAU - Qin, Yan-Yan
AU  - Qin YY
AD  - Department of Medical Immunology, Medical School of Nantong University, Nantong 
      226001, Jiangsu Province, China.
FAU - Wang, Li
AU  - Wang L
AD  - Research Center for Intelligent Information Technology, Nantong University, 
      Nantong 226019, Jiangsu Province, China.
FAU - Yao, Deng-Fu
AU  - Yao DF
AD  - Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, 
      Nantong 226001, Jiangsu Province, China. yaodf@ahnmc.com.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - EC 2.3.1.21 (Carnitine O-Palmitoyltransferase)
RN  - 0 (Fatty Acids)
RN  - S7UI8SM58A (Carnitine)
RN  - 0 (GPC3 protein, human)
RN  - 0 (Glypicans)
SB  - IM
MH  - Humans
MH  - *Non-alcoholic Fatty Liver Disease/metabolism
MH  - Carnitine O-Palmitoyltransferase/genetics/metabolism
MH  - Liver/metabolism
MH  - Carcinogenesis/metabolism
MH  - Fatty Acids/metabolism
MH  - Oxidation-Reduction
MH  - Carnitine/metabolism
MH  - Glypicans/metabolism
PMC - PMC10080702
OTO - NOTNLM
OT  - Carnitine
OT  - Carnitine palmitoyl transferase-II
OT  - Fatty acid beta-oxidation
OT  - Hepatocyte malignant transformation
OT  - Mitochondrial membrane
OT  - Nonalcoholic fatty liver disease
COIS- Conflict-of-interest statement: All the authors report no relevant conflicts of 
      interest for this article.
EDAT- 2023/04/11 06:00
MHDA- 2023/04/11 06:42
PMCR- 2023/03/28
CRDT- 2023/04/10 03:45
PHST- 2022/06/20 00:00 [received]
PHST- 2022/08/04 00:00 [revised]
PHST- 2023/03/09 00:00 [accepted]
PHST- 2023/04/11 06:42 [medline]
PHST- 2023/04/10 03:45 [entrez]
PHST- 2023/04/11 06:00 [pubmed]
PHST- 2023/03/28 00:00 [pmc-release]
AID - 10.3748/wjg.v29.i12.1765 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2023 Mar 28;29(12):1765-1778. doi: 
      10.3748/wjg.v29.i12.1765.