PMID- 37033221 OWN - NLM STAT- MEDLINE DCOM- 20230411 LR - 20230414 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 14 DP - 2023 TI - Non-linear association of fasting C-peptide and uric acid levels with renal dysfunction based on restricted cubic spline in patients with type 2 diabetes: A real-world study. PG - 1157123 LID - 10.3389/fendo.2023.1157123 [doi] LID - 1157123 AB - BACKGROUND: Previous studies had showed divergent findings on the associations of C-peptide and/or uric acid (UA) with renal dysfunction odds in patients with type 2 diabetes mellitus (T2DM). We hypothesized that there were non-linear relationships between C-peptide, UA and renal dysfunction odds. This study aimed to further investigate the relationships of different stratification of C-peptide and UA with renal dysfunction in patients with T2DM. METHOD: We conducted a cross-sectional real-world observational study of 411 patients with T2DM. The levels of fasting C-peptide, 2h postprandial C-peptide, the ratio of fasting C-peptide to 2h postprandial C-peptide (C0/C2 ratio), UA and other characteristics were recorded. Restricted cubic spline (RCS) curves was performed to evaluated the associations of stratified C-peptide and UA with renal dysfunction odds. RESULTS: Fasting C-peptide, C0/C2 ratio and UA were independently and significantly associated with renal dysfunction in patients with T2DM as assessed by multivariate analyses (p < 0.05). In especial, non-linear relationships with threshold effects were observed among fasting C-peptide, UA and renal dysfunction according to RCS analyses. Compared with patients with 0.28 0.56 nmol/L (OR = 1.85, p = 0.021) had relatively higher renal dysfunction odds after adjusting for confounding factors. Similarly, compared with patients with 276 409 mumol/L (OR = 6.24, p < 0.001) had relatively higher odds of renal dysfunction. CONCLUSION: The renal dysfunction odds in patients with T2DM was non-linearly associated with the levels of serum fasting C-peptide and UA. Fasting C-peptide and UA might have the potential role in odds stratification of renal dysfunction. CI - Copyright (c) 2023 Chen, Hu, Ma and Wang. FAU - Chen, Lu AU - Chen L AD - Department of Clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China. FAU - Hu, Yifei AU - Hu Y AD - Department of Clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China. FAU - Ma, Yongjun AU - Ma Y AD - Department of Clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China. FAU - Wang, Huabin AU - Wang H AD - Department of Clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China. AD - Central Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China. LA - eng PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20230323 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (C-Peptide) RN - 268B43MJ25 (Uric Acid) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2 MH - C-Peptide MH - Uric Acid MH - Cross-Sectional Studies MH - Fasting MH - *Kidney Diseases PMC - PMC10076627 OTO - NOTNLM OT - C-peptide OT - non-linear association OT - renal dysfunction OT - type 2 diabetes OT - uric acid COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2023/04/11 06:00 MHDA- 2023/04/11 06:42 PMCR- 2023/01/01 CRDT- 2023/04/10 03:51 PHST- 2023/02/02 00:00 [received] PHST- 2023/03/08 00:00 [accepted] PHST- 2023/04/11 06:42 [medline] PHST- 2023/04/10 03:51 [entrez] PHST- 2023/04/11 06:00 [pubmed] PHST- 2023/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2023.1157123 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2023 Mar 23;14:1157123. doi: 10.3389/fendo.2023.1157123. eCollection 2023.