PMID- 37033260
OWN - NLM
STAT- MEDLINE
DCOM- 20230411
LR  - 20230414
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 14
DP  - 2023
TI  - Food deprivation differentially modulates gene expression of LPXRFa and 
      kisspeptin systems in the brain-pituitary axis of half-smooth tongue sole 
      (Cynoglossus semilaevis).
PG  - 1099832
LID - 10.3389/fendo.2023.1099832 [doi]
LID - 1099832
AB  - LPXRFa, also known as gonadotropin-inhibitory hormone (GnIH), and kisspeptin 
      (Kiss) are two major hypothalamic peptides that modulate the reproductive axis of 
      vertebrates, including teleosts. However, little information is available 
      regarding the actions of nutritional status on the regulation of these two 
      neuroendocrine systems in fish. Herein, we assessed the effects of starvation and 
      refeeding on the expression of lpxrfa, kiss2 and their receptors (lpxrfa-r and 
      kiss2r respectively) at the brain-pituitary level of half-smooth tongue sole 
      (Cynoglossus semilaevis). Food deprivation for 4 weeks induced a rise in brain 
      lpxrfa as well as brain and pituitary lpxrfa-r mRNA levels, and refeeding 
      restored brain lpxrfa and lpxrfa-r expression back to normal. However, pituitary 
      lpxrfa-r mRNA levels still remained high after 1 week of refeeding. Neither 
      lpxrfa nor kiss2 transcripts in the pituitary were altered by fasting, but their 
      mRNA levels increased significantly after 1 week of refeeding, and declined back 
      to the control levels after 2 weeks of refeeding. None of brain kiss2 and kiss2r 
      along with pituitary kiss2r transcripts were modified by the nutritional status. 
      In summary, our results revealed an interaction between energy status and the 
      elements of LPXRFa and Kiss systems in the brain-pituitary axis of half-smooth 
      tongue sole. Food deprivation and refeeding differentially regulated the two 
      systems, which provided additional evidence for the involvement of the LPXRFa and 
      Kiss systems in the regulation of reproduction by energy balance in non-mammalian 
      species.
CI  - Copyright (c) 2023 Wang, Cui, Xu, Zhang, Jiang and Liu.
FAU - Wang, Bin
AU  - Wang B
AD  - Key Laboratory of Sustainable Development of Marine Fisheries, Ministry of 
      Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese 
      Academy of Fishery Sciences, Qingdao, China.
AD  - Joint Laboratory for Deep Blue Fishery Engineering, Pilot National Laboratory for 
      Marine Science and Technology (Qingdao), Qingdao, China.
FAU - Cui, Aijun
AU  - Cui A
AD  - Key Laboratory of Sustainable Development of Marine Fisheries, Ministry of 
      Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese 
      Academy of Fishery Sciences, Qingdao, China.
AD  - Joint Laboratory for Deep Blue Fishery Engineering, Pilot National Laboratory for 
      Marine Science and Technology (Qingdao), Qingdao, China.
FAU - Xu, Yongjiang
AU  - Xu Y
AD  - Key Laboratory of Sustainable Development of Marine Fisheries, Ministry of 
      Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese 
      Academy of Fishery Sciences, Qingdao, China.
AD  - Joint Laboratory for Deep Blue Fishery Engineering, Pilot National Laboratory for 
      Marine Science and Technology (Qingdao), Qingdao, China.
FAU - Zhang, Yaxing
AU  - Zhang Y
AD  - Key Laboratory of Sustainable Development of Marine Fisheries, Ministry of 
      Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese 
      Academy of Fishery Sciences, Qingdao, China.
FAU - Jiang, Yan
AU  - Jiang Y
AD  - Key Laboratory of Sustainable Development of Marine Fisheries, Ministry of 
      Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese 
      Academy of Fishery Sciences, Qingdao, China.
AD  - Joint Laboratory for Deep Blue Fishery Engineering, Pilot National Laboratory for 
      Marine Science and Technology (Qingdao), Qingdao, China.
FAU - Liu, Xuezhou
AU  - Liu X
AD  - Key Laboratory of Sustainable Development of Marine Fisheries, Ministry of 
      Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese 
      Academy of Fishery Sciences, Qingdao, China.
AD  - Joint Laboratory for Deep Blue Fishery Engineering, Pilot National Laboratory for 
      Marine Science and Technology (Qingdao), Qingdao, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230324
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Kisspeptins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - *Kisspeptins/genetics/metabolism
MH  - *Food Deprivation
MH  - Fishes/genetics
MH  - Brain/metabolism
MH  - RNA, Messenger/genetics/metabolism
MH  - Gene Expression
PMC - PMC10081681
OTO - NOTNLM
OT  - Cynoglossus semilaevis
OT  - LPXRFa
OT  - LPXRFa receptor
OT  - kisspeptin
OT  - kisspeptin receptor
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/04/11 06:00
MHDA- 2023/04/11 06:42
PMCR- 2023/01/01
CRDT- 2023/04/10 03:51
PHST- 2022/11/16 00:00 [received]
PHST- 2023/03/15 00:00 [accepted]
PHST- 2023/04/11 06:42 [medline]
PHST- 2023/04/10 03:51 [entrez]
PHST- 2023/04/11 06:00 [pubmed]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2023.1099832 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2023 Mar 24;14:1099832. doi: 
      10.3389/fendo.2023.1099832. eCollection 2023.