PMID- 37033531
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230412
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 3
DP  - 2023 Mar
TI  - Congenital Adrenal Hyperplasia and Human Leukocyte Antigen B: A Meta-Analysis.
PG  - e35900
LID - 10.7759/cureus.35900 [doi]
LID - e35900
AB  - The link between specific human leukocyte antigen (HLA)-B genes and congenital 
      adrenal hyperplasia (CAH) has been a subject of interest. This study investigates 
      the association between specific HLA-B haplotypes and CAH through a 
      meta-analysis. Google Scholar was used as a database. Articles were included if 
      the research was conducted between 1970 and 2022, was not a meta-analysis, and 
      had odds ratios or enough data points to calculate an odds ratio. The National 
      Institutes of Health (NIH) quality assessment tool of case-control studies was 
      used to evaluate the risk of bias in individual studies, and MetaXL was used to 
      generate data and create a forest plot for analysis. Twelve studies met the 
      selection criteria and were included in the study (641 patients and 3,614 
      controls). Two HLA-B haplotypes showed increased odds of CAH compared to 
      controls: B14 (OR=3.81; 95%CI=2.88, 5.05; I(2)=3%) and B35 (OR=1.88; 95%CI=1.22, 
      2.90; I(2)=25%). All other HLAs either showed no significant effect or had high 
      heterogeneity. The results suggest that specific HLA-B haplotypes have increased 
      odds of developing CAH, specifically B14 and B35. These findings may prove 
      helpful in the pre- and post-natal diagnosis of CAH as well as the identification 
      of carriers and prediction of patient prognosis.
CI  - Copyright (c) 2023, Thibaut et al.
FAU - Thibaut, Dylan
AU  - Thibaut D
AD  - Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA.
FAU - Walter, Madison R
AU  - Walter MR
AD  - Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA.
FAU - McGonegal, Courtney
AU  - McGonegal C
AD  - Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA.
FAU - Daniel, Ryan
AU  - Daniel R
AD  - Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA.
FAU - Goodman, Jerry
AU  - Goodman J
AD  - Obstetrics and Gynecology, Lake Erie College of Osteopathic Medicine, Bradenton, 
      USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230308
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10081860
OTO - NOTNLM
OT  - 21-hydroxylase deficiency
OT  - cah
OT  - congenital adrenal hyperplasia
OT  - haplotype
OT  - hla
OT  - hla-b
OT  - human leukocyte antigen
OT  - mhc
OT  - mhc class i
OT  - non-classical congenital adrenal hyperplasia
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/04/11 06:00
MHDA- 2023/04/11 06:01
PMCR- 2023/03/08
CRDT- 2023/04/10 03:55
PHST- 2022/11/21 00:00 [received]
PHST- 2023/03/07 00:00 [accepted]
PHST- 2023/04/11 06:01 [medline]
PHST- 2023/04/10 03:55 [entrez]
PHST- 2023/04/11 06:00 [pubmed]
PHST- 2023/03/08 00:00 [pmc-release]
AID - 10.7759/cureus.35900 [doi]
PST - epublish
SO  - Cureus. 2023 Mar 8;15(3):e35900. doi: 10.7759/cureus.35900. eCollection 2023 Mar.