PMID- 37033638
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230412
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 14
DP  - 2023
TI  - Analysis of patient medication compliance and quality of life of 
      physician-pharmacist collaborative clinics for T2DM management in primary 
      healthcare in China: A mixed-methods study.
PG  - 1098207
LID - 10.3389/fphar.2023.1098207 [doi]
LID - 1098207
AB  - Background: Physician-pharmacist collaboration is a well-established care mode 
      for the management of type 2 diabetes mellitus (T2DM) in developed countries, but 
      no study has been conducted in primary healthcare in China. This study aims to 
      evaluate the effects of physician-pharmacist collaborative clinics to manage T2DM 
      in primary healthcare in China, and to better understand the factors influencing 
      the implementation of physician-pharmacist collaborative clinics. Methods: Two 
      hundred and sixty-seven patients involved in a 12-month randomized controlled 
      trial were assigned to physician-pharmacist collaborative clinics and usual 
      clinics, completing surveys regarding medication compliance, quality of life 
      (QoL) and care-seeking behavior at the baseline, 3rd, 6th, 9th and 12th month 
      respectively, and diabetes knowledge at baseline and 12th month. A sample of 
      twenty-two Patients, nine physicians and twelve pharmacists participated in 
      semi-structured face-to-face interviews. The quantitative and qualitative data 
      was integrated by triangulation. Results: Patients in physician-pharmacist 
      collaborative clinics had significant improvements in medication compliance (p = 
      0.009), QoL (p = 0.036) and emergency visits (p = 0.003) over the 12-month. 
      Pairwise comparison showed the medication compliance score in the intervention 
      group had been significantly improved at 3rd month (p = 0.001), which is more 
      rapidly than that in the control group at 9th month (p = 0.030). Factors 
      influencing the implementation of physician-pharmacist collaborative clinics were 
      driven by five themes: pharmaceutical service, team-base care, psychological 
      support, acceptability of care and barriers to implementation. Conclusion: 
      Integration of quantitative and qualitative findings showed the effectiveness of 
      physician-pharmacist collaborative clinics in patient medication compliance and 
      QoL in primary healthcare. The qualitative study uncovered barriers in 
      insufficient clinical experience and understaffing of pharmacist. Therefore, the 
      professional training of the primary pharmacist team should be improved in the 
      future. Clinical Trial Registration: clinicaltrials.gov, identifier 
      ChiCTR2000031839.
CI  - Copyright (c) 2023 Xiao, Wang, Tan, Chen, Tang, Huang, Zhou and Xu.
FAU - Xiao, Jie
AU  - Xiao J
AD  - Department of Pharmacy, The Second Xiangya Hospital, Central South University, 
      Changsha, China.
AD  - Institute of Clinical Pharmacy, The Second Xiangya Hospital, Central South 
      University, Changsha, China.
FAU - Wang, Qing
AU  - Wang Q
AD  - Department of Pharmacy, The Second Xiangya Hospital, Central South University, 
      Changsha, China.
AD  - Institute of Clinical Pharmacy, The Second Xiangya Hospital, Central South 
      University, Changsha, China.
FAU - Tan, Shenglan
AU  - Tan S
AD  - Department of Pharmacy, The Second Xiangya Hospital, Central South University, 
      Changsha, China.
AD  - Institute of Clinical Pharmacy, The Second Xiangya Hospital, Central South 
      University, Changsha, China.
FAU - Chen, Lei
AU  - Chen L
AD  - Department of Pharmacy, The Second Xiangya Hospital, Central South University, 
      Changsha, China.
AD  - Institute of Clinical Pharmacy, The Second Xiangya Hospital, Central South 
      University, Changsha, China.
FAU - Tang, Bingjie
AU  - Tang B
AD  - Department of Pharmacy, The Second Xiangya Hospital, Central South University, 
      Changsha, China.
AD  - Institute of Clinical Pharmacy, The Second Xiangya Hospital, Central South 
      University, Changsha, China.
FAU - Huang, Shuting
AU  - Huang S
AD  - Department of Pharmacy, The Second Xiangya Hospital, Central South University, 
      Changsha, China.
AD  - Institute of Clinical Pharmacy, The Second Xiangya Hospital, Central South 
      University, Changsha, China.
FAU - Zhou, Yangang
AU  - Zhou Y
AD  - Department of Pharmacy, The Second Xiangya Hospital, Central South University, 
      Changsha, China.
AD  - Institute of Clinical Pharmacy, The Second Xiangya Hospital, Central South 
      University, Changsha, China.
FAU - Xu, Ping
AU  - Xu P
AD  - Department of Pharmacy, The Second Xiangya Hospital, Central South University, 
      Changsha, China.
AD  - Institute of Clinical Pharmacy, The Second Xiangya Hospital, Central South 
      University, Changsha, China.
LA  - eng
PT  - Journal Article
DEP - 20230324
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC10080104
OTO - NOTNLM
OT  - diabetes milletus
OT  - medication compliance
OT  - pharmacist
OT  - primary healtcare
OT  - quality of life
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/04/11 06:00
MHDA- 2023/04/11 06:01
PMCR- 2023/03/24
CRDT- 2023/04/10 03:55
PHST- 2022/11/14 00:00 [received]
PHST- 2023/03/16 00:00 [accepted]
PHST- 2023/04/11 06:01 [medline]
PHST- 2023/04/10 03:55 [entrez]
PHST- 2023/04/11 06:00 [pubmed]
PHST- 2023/03/24 00:00 [pmc-release]
AID - 1098207 [pii]
AID - 10.3389/fphar.2023.1098207 [doi]
PST - epublish
SO  - Front Pharmacol. 2023 Mar 24;14:1098207. doi: 10.3389/fphar.2023.1098207. 
      eCollection 2023.