PMID- 37034540
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230411
IS  - 1734-1922 (Print)
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Linking)
VI  - 19
IP  - 2
DP  - 2023
TI  - Platelet reactivity expressed as a novel platelet reactivity score is associated 
      with higher inflammatory state after coronary artery bypass grafting.
PG  - 392-400
LID - 10.5114/aoms.2019.90470 [doi]
AB  - INTRODUCTION: Despite therapy, patients operated using a cardiopulmonary bypass 
      demonstrate increased platelet aggregation, which rebounds to above preoperative 
      levels. The aim of the study was to test the interaction between platelet 
      reactivity/activation and selected inflammatory markers in the post-operative 
      period. MATERIAL AND METHODS: In total, 103 patients with non-ST elevation acute 
      coronary syndrome (NSTE-ACS) who were not eligible for percutaneous coronary 
      interventions (PCI), and required urgent revascularization, were included. 
      Platelet reactivity was measured using the PFA-100 platelet analyser, multiple 
      electrode aggregometry, and was expressed as a novel platelet reactivity score 
      (PRS). Patients were divided using their PRS scores into high platelet relativity 
      or low platelet reactivity subgroups (HPR or LPR). Platelet basal activation was 
      measured using immunoassays for soluble P-selectin and soluble CD40L. We measured 
      high-sensitivity C-reactive protein (CRP), and used immunoassays for tumour 
      necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) as inflammation markers. 
      RESULTS: Significant differences between HPR and LPR groups were found for CRP 
      (mg/l): 81.5 vs. 44.6, p < 0.02; and TNF-alpha (pg/l): 3.51 vs. 2.37, p < 0.02. A 
      significant association was found between CRP, TNF-alpha, IL-6 and platelet 
      reactivity (platelet reactivity score). Cohen's k showed: CRP = 0.49, p < 0.0001, 
      TNF-alpha = 0.37, p < 0.002. Perioperative myocardial infarction and rhythm 
      disturbances occurred more frequently in the high platelet reactivity group: 7 
      (16.3%) vs. 2 (3.3%), p < 0.04, and 9 (20.9%) vs. 4 (6.7%), p < 0.04, 
      respectively. CONCLUSIONS: Inflammatory parameters CRP and TNF-alpha are strongly 
      associated with platelet reactivity (expressed as PRS) in cardiopulmonary bypass 
      graft patients. Platelet hyperreactivity in the early post-operative period 
      combined with a systemic inflammatory state correlates with a higher risk of 
      post-operative rhythm disturbances and myocardial infarction.
CI  - Copyright: (c) 2019 Termedia & Banach.
FAU - Wilczynski, Miroslaw
AU  - Wilczynski M
AD  - Department of Cardiac Surgery, Chair of Cardiology and Cardiac Surgery, Medical 
      University of Lodz, Lodz, Poland.
FAU - Krejca, Michal
AU  - Krejca M
AD  - Department of Cardiac Surgery, Chair of Cardiology and Cardiac Surgery, Medical 
      University of Lodz, Lodz, Poland.
FAU - Stepinski, Piotr
AU  - Stepinski P
AD  - Department of Cardiac Surgery, Chair of Cardiology and Cardiac Surgery, Medical 
      University of Lodz, Lodz, Poland.
FAU - Rozalski, Marcin
AU  - Rozalski M
AD  - Department of Haemostasis and Haemostatic Disorders, Medical University of Lodz, 
      Lodz, Poland.
FAU - Golanski, Jacek
AU  - Golanski J
AD  - Department of Haemostasis and Haemostatic Disorders, Medical University of Lodz, 
      Lodz, Poland.
LA  - eng
PT  - Journal Article
DEP - 20191212
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC10074322
OTO - NOTNLM
OT  - cardiopulmonary bypass
OT  - coronary artery bypass grafting
OT  - inflammation
OT  - platelet activation
OT  - platelet reactivity
COIS- The authors declare no conflict of interest.
EDAT- 2019/12/12 00:00
MHDA- 2019/12/12 00:01
PMCR- 2019/12/12
CRDT- 2023/04/10 04:09
PHST- 2019/05/28 00:00 [received]
PHST- 2019/08/19 00:00 [accepted]
PHST- 2019/12/12 00:01 [medline]
PHST- 2023/04/10 04:09 [entrez]
PHST- 2019/12/12 00:00 [pubmed]
PHST- 2019/12/12 00:00 [pmc-release]
AID - 111842 [pii]
AID - 10.5114/aoms.2019.90470 [doi]
PST - epublish
SO  - Arch Med Sci. 2019 Dec 12;19(2):392-400. doi: 10.5114/aoms.2019.90470. 
      eCollection 2023.