PMID- 37034991
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230411
IS  - 2589-0042 (Electronic)
IS  - 2589-0042 (Linking)
VI  - 26
IP  - 4
DP  - 2023 Apr 21
TI  - Mannose-coated nanozyme for relief from chemotherapy-induced peripheral 
      neuropathic pain.
PG  - 106414
LID - 10.1016/j.isci.2023.106414 [doi]
LID - 106414
AB  - Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a progressive and 
      disturbing peripheral neuropathy with currently no effective treatment. Aberrant 
      production of reactive oxygen species (ROS) in macrophages near peripheral nerves 
      plays a dominant role in CIPNP; however, traditional ROS scavengers have 
      difficulty maintaining viability to target macrophages in vivo. Mannose-coated 
      superparamagnetic iron oxide nanoparticles (mSPIONs) were synthesized to treat 
      CIPNP. The anti-ROS and anti-inflammatory effects of mSPIONs were assessed in 
      J774A.1 cells and sciatic nerves in a nociception mouse model induced with 
      vincristine (VCR). We found that the mSPIONs significantly reduced ROS levels 
      in vitro and in vivo. Furthermore, mSPIONs administration specifically reduced 
      IL-6 and TNF-alpha levels in macrophages near the sciatic nerve and relieved 
      VCR-induced peripheral neuropathic pain. Inhibition of the VCR-upregulated 
      HIF1alpha/NF-kappaB signaling pathway may be involved in the alleviation of inflammation. 
      These results provide a new approach for relieving CIPNP using a nanozyme.
CI  - (c) 2023 The Author(s).
FAU - Liu, Hu
AU  - Liu H
AD  - Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical 
      University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui 
      Higher Education Institutes, Anhui Medical University, No. 218 Jixi Road, Hefei, 
      Anhui Province 20032, China.
FAU - Qing, Xin
AU  - Qing X
AD  - Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical 
      University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui 
      Higher Education Institutes, Anhui Medical University, No. 218 Jixi Road, Hefei, 
      Anhui Province 20032, China.
FAU - Peng, Lijun
AU  - Peng L
AD  - Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical 
      University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui 
      Higher Education Institutes, Anhui Medical University, No. 218 Jixi Road, Hefei, 
      Anhui Province 20032, China.
FAU - Zhang, Ding
AU  - Zhang D
AD  - Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical 
      University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui 
      Higher Education Institutes, Anhui Medical University, No. 218 Jixi Road, Hefei, 
      Anhui Province 20032, China.
FAU - Dai, Wei
AU  - Dai W
AD  - Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical 
      University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui 
      Higher Education Institutes, Anhui Medical University, No. 218 Jixi Road, Hefei, 
      Anhui Province 20032, China.
FAU - Yang, Zhilai
AU  - Yang Z
AD  - Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical 
      University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui 
      Higher Education Institutes, Anhui Medical University, No. 218 Jixi Road, Hefei, 
      Anhui Province 20032, China.
FAU - Zhang, Jiqian
AU  - Zhang J
AD  - Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical 
      University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui 
      Higher Education Institutes, Anhui Medical University, No. 218 Jixi Road, Hefei, 
      Anhui Province 20032, China.
FAU - Liu, Xuesheng
AU  - Liu X
AD  - Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical 
      University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui 
      Higher Education Institutes, Anhui Medical University, No. 218 Jixi Road, Hefei, 
      Anhui Province 20032, China.
LA  - eng
PT  - Journal Article
DEP - 20230317
PL  - United States
TA  - iScience
JT  - iScience
JID - 101724038
PMC - PMC10074233
OTO - NOTNLM
OT  - Immunology
OT  - Molecular physiology
OT  - Nanotechnology
OT  - Neuroscience
COIS- The authors declare no competing interests.
EDAT- 2023/04/11 06:00
MHDA- 2023/04/11 06:01
PMCR- 2023/03/17
CRDT- 2023/04/10 04:15
PHST- 2022/05/06 00:00 [received]
PHST- 2023/01/04 00:00 [revised]
PHST- 2023/03/13 00:00 [accepted]
PHST- 2023/04/11 06:01 [medline]
PHST- 2023/04/10 04:15 [entrez]
PHST- 2023/04/11 06:00 [pubmed]
PHST- 2023/03/17 00:00 [pmc-release]
AID - S2589-0042(23)00491-1 [pii]
AID - 106414 [pii]
AID - 10.1016/j.isci.2023.106414 [doi]
PST - epublish
SO  - iScience. 2023 Mar 17;26(4):106414. doi: 10.1016/j.isci.2023.106414. eCollection 
      2023 Apr 21.