PMID- 37035395
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230411
IS  - 2224-4344 (Print)
IS  - 2224-4344 (Electronic)
IS  - 2224-4336 (Linking)
VI  - 12
IP  - 3
DP  - 2023 Mar 31
TI  - Analysis of the efficacy of Dabuyin pill combined with gonadotropin-releasing 
      hormone analogue in the treatment of central precocious puberty girls based on 
      network pharmacology.
PG  - 364-374
LID - 10.21037/tp-23-111 [doi]
AB  - BACKGROUND: Traditional Chinese medicine (TCM) believes that central precocious 
      puberty (CPP) is affected by the imbalance of kidney Yin and Yang. Dabuyin pill 
      is a recipe for nourishing Yin and lowering fire. The network pharmacology method 
      was used to analyze the active components, action targets, and molecular pathways 
      of Dabuyin pill in the treatment of CPP. METHODS: The main chemical components of 
      Dabuyin pill were obtained from the Integrative database of Traditional Chinese 
      Medicine enhanced by Symptom Mapping (SymMap) database and Traditional Chinese 
      Medicine Systems Pharmacology (TCMSP), and compound targets were retrieved from 
      SymMap and the Encyclopedia of Traditional Chinese Medicine (ETCM). Disease 
      targets were retrieved from the DisGeNET and Gene Expression Omnibus (GEO) 
      databases, and the intersection of compound targets and disease targets was 
      performed to obtain the prediction targets of Dabuyin pill acting on CPP. The key 
      targets enriched by Database for Annotation, Visualization, and Integrated 
      Discovery (DAVID) were then used for Gene Ontology (GO) functional enrichment and 
      Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. RESULTS: GO 
      analysis showed that the biological functions of Dabuyin pill in the treatment of 
      key targets of CPP mainly involved apoptosis, nitric oxide synthesis, estradiol 
      response, angiogenesis, inflammation, and so on. KEGG pathway analysis was mainly 
      enriched in the tumor necrosis factor (TNF) signaling pathway, 
      phosphatidylinositol-3 kinase/protein kinase B (PI3K/Akt) signaling pathway, 
      hypoxia-inducible factor-1 (HIF-1) signaling pathway, and apoptosis. Among them, 
      the regulation effect of Dabuyin pill prescription on apoptosis may both act on 
      TP53 and different signaling pathways of apoptosis, thus playing a synergistic 
      role. CONCLUSIONS: Dabuyin pill combined with GnRHa for the prevention and 
      treatment of CPP in girls can effectively intervene CPP, and the effect of 
      Dabuyin pill on sex hormones is one of its protective mechanisms against CPP.
CI  - 2023 Translational Pediatrics. All rights reserved.
FAU - Chen, Xiaohong
AU  - Chen X
AD  - Department of Pediatrics, Central Hospital of Haining, Haining, China.
FAU - Zheng, Min
AU  - Zheng M
AD  - Day Surgery Center, Children's Hospital of Wuhan, Wuhan, China.
FAU - Fei, Xiaoling
AU  - Fei X
AD  - Department of Pediatrics, Central Hospital of Haining, Haining, China.
FAU - Ma, Xiaohui
AU  - Ma X
AD  - Department of Pediatrics, Central Hospital of Haining, Haining, China.
LA  - eng
PT  - Journal Article
DEP - 20230330
PL  - China
TA  - Transl Pediatr
JT  - Translational pediatrics
JID - 101649179
PMC - PMC10080485
OTO - NOTNLM
OT  - Dabuyin pill
OT  - bioinformatics analysis
OT  - central precocious puberty (CPP)
OT  - network pharmacology
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at 
      https://tp.amegroups.com/article/view/10.21037/tp-23-111/coif). The authors have 
      no conflicts of interest to declare.
EDAT- 2023/04/11 06:00
MHDA- 2023/04/11 06:01
PMCR- 2023/03/31
CRDT- 2023/04/10 04:20
PHST- 2022/12/11 00:00 [received]
PHST- 2023/03/23 00:00 [accepted]
PHST- 2023/04/11 06:01 [medline]
PHST- 2023/04/10 04:20 [entrez]
PHST- 2023/04/11 06:00 [pubmed]
PHST- 2023/03/31 00:00 [pmc-release]
AID - tp-12-03-364 [pii]
AID - 10.21037/tp-23-111 [doi]
PST - ppublish
SO  - Transl Pediatr. 2023 Mar 31;12(3):364-374. doi: 10.21037/tp-23-111. Epub 2023 Mar 
      30.