PMID- 37036901
OWN - NLM
STAT- MEDLINE
DCOM- 20230531
LR  - 20230813
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 136
IP  - 8
DP  - 2023 Apr 20
TI  - Enthesitis in patients with psoriatic arthritis: A nationwide data from the 
      Chinese Registry of Psoriatic Arthritis (CREPAR).
PG  - 951-958
LID - 10.1097/CM9.0000000000002646 [doi]
AB  - BACKGROUND: The clinical features of enthesitis in patients with psoriatic 
      arthritis (PsA) have been reported in some Western countries, but data in China 
      are very limited. This study aimed to describe the characteristics of enthesitis 
      in Chinese patients with PsA and compared them with those in other cohorts. 
      METHODS: Patients with PsA enrolled in the Chinese Registry of Psoriatic 
      Arthritis (CREPAR) (December 2018 to June 2021) were included. Data including 
      demographics, clinical characteristics, disease activity measures, and treatment 
      were collected at enrollment. Enthesitis was assessed by the Spondyloarthritis 
      Research Consortium of Canada (SPARCC), Maastricht ankylosing spondylitis 
      enthesitis score (MASES), and Leeds enthesitis index (LEI) indices. A 
      multivariable logistic model was used to identify factors related to enthesitis. 
      We also compared our results with those of other cohorts. RESULTS: In total, 1074 
      PsA patients were included, 308 (28.7%) of whom had enthesitis. The average 
      number of enthesitis was 3.3 +/- 2.8 (range: 1.0-18.0). More than half of the 
      patients (165, 53.6%) had one or two tender entheseal sites. Patients with 
      enthesitis had an earlier age of onset for both psoriasis and arthritis, reported 
      a higher proportion of PsA duration over 5 years, and had a higher percentage of 
      axial involvement and greater disease activity. Multivariable logistic regression 
      showed that axial involvement (odds ratio [OR] 2.21, 95% confidence interval 
      [CI], 1.59-3.08; P <0.001), psoriasis area and severity index (PASI) (OR: 1.03, 
      95% CI: 1.01-1.04; P = 0.002), and disease activity score 28-C reactive protein 
      (DAS28-CRP) (OR: 1.25, 95% CI: 1.01-1.55; P = 0.037) were associated with 
      enthesitis. Compared with the results of other studies, Chinese patients with 
      enthesitis had a younger age, lower body mass index (BMI), a higher rate of 
      positive human leukocyte antigen (HLA)-B27, more frequent dactylitis, and a 
      higher proportion of conventional synthetic disease-modifying antirheumatic 
      drugs' (csDMARDs) use. CONCLUSIONS: Enthesitis is a common condition among 
      Chinese patients with PsA. It is important to evaluate entheses in both 
      peripheral and axial sites.
CI  - Copyright (c) 2023 The Chinese Medical Association, produced by Wolters Kluwer, 
      Inc. under the CC-BY-NC-ND license.
FAU - Yang, Fan
AU  - Yang F
AD  - Department of Rheumatology and Clinical Immunology, Peking Union Medical College 
      Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 
      National Clinical Research Center for Dermatologic and Immunologic Diseases 
      (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of 
      Education, Beijing 100730, China.
FAU - Lu, Chaofan
AU  - Lu C
AD  - Department of Rheumatology and Clinical Immunology, Peking Union Medical College 
      Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 
      National Clinical Research Center for Dermatologic and Immunologic Diseases 
      (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of 
      Education, Beijing 100730, China.
FAU - Liu, Huilan
AU  - Liu H
AD  - Department of Rheumatology and Clinical Immunology, Peking Union Medical College 
      Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 
      National Clinical Research Center for Dermatologic and Immunologic Diseases 
      (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of 
      Education, Beijing 100730, China.
FAU - Dou, Lei
AU  - Dou L
AD  - Department of Rheumatology and Immunology, The Second People's Hospital of Wuhu, 
      Wuhu, Anhui 241000, China.
FAU - Wang, Yanhong
AU  - Wang Y
AD  - Department of Epidemiology and Biostatistics, Institute of Basic Medical 
      Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 
      Beijing 100005, China.
FAU - Li, Hongbin
AU  - Li H
AD  - The Division of Rheumatology, The Affiliated Hospital of Inner Mongolia Medical 
      University, Hohhot, Inner Mongolia 010110, China.
FAU - Duan, Xinwang
AU  - Duan X
AD  - Department of Rheumatology, The Second Affiliated Hospital of Nanchang 
      University, Nanchang, Jiangxi 330006, China.
FAU - Wu, Lijun
AU  - Wu L
AD  - Department of Rheumatology and Immunology, The People's Hospital of the Xinjiang 
      Uygur Autonomous Region, Urumqi, Xinjiang 830001, China.
FAU - Wang, Yongfu
AU  - Wang Y
AD  - Department of Rheumatology, First Affiliated Hospital of Baotou Medical College, 
      Baotou, Inner Mongolia 014010, China.
FAU - Zhang, Xiuying
AU  - Zhang X
AD  - Department of Rheumatology, Zibo Central Hospital, Zibo, Shandong 255036, China.
FAU - Xu, Jian
AU  - Xu J
AD  - Department of Rheumatology, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, Yunnan 650032, China.
FAU - Su, Jinmei
AU  - Su J
AD  - Department of Rheumatology and Clinical Immunology, Peking Union Medical College 
      Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 
      National Clinical Research Center for Dermatologic and Immunologic Diseases 
      (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of 
      Education, Beijing 100730, China.
FAU - Xu, Dong
AU  - Xu D
AD  - Department of Rheumatology and Clinical Immunology, Peking Union Medical College 
      Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 
      National Clinical Research Center for Dermatologic and Immunologic Diseases 
      (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of 
      Education, Beijing 100730, China.
FAU - Zhao, Jiuliang
AU  - Zhao J
AD  - Department of Rheumatology and Clinical Immunology, Peking Union Medical College 
      Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 
      National Clinical Research Center for Dermatologic and Immunologic Diseases 
      (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of 
      Education, Beijing 100730, China.
FAU - Wu, Qingjun
AU  - Wu Q
AD  - Department of Rheumatology and Clinical Immunology, Peking Union Medical College 
      Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 
      National Clinical Research Center for Dermatologic and Immunologic Diseases 
      (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of 
      Education, Beijing 100730, China.
FAU - Li, Mengtao
AU  - Li M
AD  - Department of Rheumatology and Clinical Immunology, Peking Union Medical College 
      Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 
      National Clinical Research Center for Dermatologic and Immunologic Diseases 
      (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of 
      Education, Beijing 100730, China.
FAU - Leng, Xiaomei
AU  - Leng X
AD  - Department of Rheumatology and Clinical Immunology, Peking Union Medical College 
      Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 
      National Clinical Research Center for Dermatologic and Immunologic Diseases 
      (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of 
      Education, Beijing 100730, China.
FAU - Zeng, Xiaofeng
AU  - Zeng X
AD  - Department of Rheumatology and Clinical Immunology, Peking Union Medical College 
      Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 
      National Clinical Research Center for Dermatologic and Immunologic Diseases 
      (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of 
      Education, Beijing 100730, China.
LA  - eng
PT  - Journal Article
DEP - 20230408
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
SB  - IM
MH  - Humans
MH  - *Arthritis, Psoriatic/epidemiology/drug therapy
MH  - East Asian People
MH  - *Enthesopathy/complications
MH  - Registries
MH  - Severity of Illness Index
MH  - *Spondylarthritis/epidemiology
PMC - PMC10278716
COIS- None.
EDAT- 2023/04/11 06:00
MHDA- 2023/05/18 06:42
PMCR- 2023/04/20
CRDT- 2023/04/10 14:03
PHST- 2022/12/23 00:00 [received]
PHST- 2023/05/18 06:42 [medline]
PHST- 2023/04/11 06:00 [pubmed]
PHST- 2023/04/10 14:03 [entrez]
PHST- 2023/04/20 00:00 [pmc-release]
AID - 00029330-202304200-00008 [pii]
AID - CMJ-2022-3489 [pii]
AID - 10.1097/CM9.0000000000002646 [doi]
PST - ppublish
SO  - Chin Med J (Engl). 2023 Apr 20;136(8):951-958. doi: 10.1097/CM9.0000000000002646. 
      Epub 2023 Apr 8.