PMID- 37037958
OWN - NLM
STAT- MEDLINE
DCOM- 20230623
LR  - 20230623
IS  - 1865-3774 (Electronic)
IS  - 0925-5710 (Linking)
VI  - 118
IP  - 1
DP  - 2023 Jul
TI  - Outcomes following induction failure in Japanese children with acute 
      lymphoblastic leukemia.
PG  - 99-106
LID - 10.1007/s12185-023-03600-3 [doi]
AB  - The characteristics and prognosis of Japanese children with acute lymphoblastic 
      leukemia (ALL) who fail to achieve complete remission after remission induction 
      chemotherapy (i.e., experience induction failure) are poorly understood. 
      Therefore, we retrospectively analyzed data of patients enrolled in Japanese 
      clinical trials for newly diagnosed ALL between 1996 and 2009. Among 4956 
      participants, 89 (1.8%) experienced induction failure. With a 6.0-year median 
      follow-up, the 5-year overall survival rate of the entire cohort was 
      43.0% +/- 5.5%. Survival rates did not differ between patients with B-cell 
      precursor ALL (BCP-ALL) and T-cell ALL (T-ALL). In multivariate analysis, day 15 
      M3 marrow (bone marrow blast count >/= 25%) was significantly correlated with 
      poorer survival in the whole or BCP-ALL cohorts. In T-ALL, age < 6 years was 
      significantly associated with poor survival. However, due to the small sample 
      size, this correlation must be further investigated. Most T-ALL and 
      BCR-ABL-positive BCP-ALL patients underwent allogeneic stem cell transplantation 
      (allo-SCT). Survival rates did not differ between BCR-ABL-negative BCP-ALL 
      patients who did and did not undergo allo-SCT, possibly due to the inclusion of 
      lower-risk patients in the latter group. In conclusion, the induction failure 
      rate and survival after diagnosis of induction failure in our study were 
      comparable to previously reported figures.
CI  - (c) 2023. Japanese Society of Hematology.
FAU - Imai, Chihaya
AU  - Imai C
AUID- ORCID: 0000-0001-7435-3464
AD  - Department of Pediatrics, Niigata University Graduate School of Medical and 
      Dental Sciences, 1-757 Asahimachi-Dori, Chuou-Ku, Niigata City, Niigata, 
      951-8510, Japan. chihaya@med.niigata-u.ac.jp.
FAU - Sato, Atsushi
AU  - Sato A
AD  - Department of Hematology and Oncology, Miyagi Children's Hospital, Miyagi, Japan.
FAU - Hiwatari, Mitsuteru
AU  - Hiwatari M
AD  - Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 
      Tokyo, Japan.
AD  - Department of Pediatrics, Teikyo University School of Medicine, Tokyo, Japan.
FAU - Shimomura, Yasuto
AU  - Shimomura Y
AD  - Department of Pediatrics, Aichi Medical University, Aichi, Japan.
FAU - Hori, Toshinori
AU  - Hori T
AD  - Department of Pediatrics, Aichi Medical University, Aichi, Japan.
FAU - Suenobu, Souichi
AU  - Suenobu S
AD  - Department of Pediatrics, Oita University, Oita, Japan.
FAU - Imamura, Toshihiko
AU  - Imamura T
AD  - Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural 
      University of Medicine, Kyoto, Japan.
FAU - Hara, Junichi
AU  - Hara J
AD  - Department of Pediatric Hematology and Oncology, Osaka City General Hospital, 
      Osaka, Japan.
FAU - Hasegawa, Daisuke
AU  - Hasegawa D
AD  - Department of Pediatrics, St. Luke's International Hospital, Tokyo, Japan.
FAU - Takahashi, Hiroyuki
AU  - Takahashi H
AD  - Department of Pediatrics, Toho University Omori Medical Center, Tokyo, Japan.
FAU - Moriya, Kunihiko
AU  - Moriya K
AD  - Department of Pediatrics, Tohoku University Graduate School of Medicine, Miyagi, 
      Japan.
FAU - Katayama, Saori
AU  - Katayama S
AD  - Department of Pediatrics, Tohoku University Graduate School of Medicine, Miyagi, 
      Japan.
FAU - Tomizawa, Daisuke
AU  - Tomizawa D
AD  - Children's Cancer Center, National Center for Child Health and Development, 
      Tokyo, Japan.
FAU - Moritake, Hiroshi
AU  - Moritake H
AD  - Department of Pediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki, 
      Japan.
FAU - Taga, Takashi
AU  - Taga T
AD  - Department of Pediatrics, Shiga University of Medical Science, Shiga, Japan.
FAU - Horibe, Keizo
AU  - Horibe K
AD  - Clinical Research Center, Nagoya Medical Center, Nagoya, Japan.
FAU - Koh, Katsuyoshi
AU  - Koh K
AD  - Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, 
      Japan.
FAU - Manabe, Atsushi
AU  - Manabe A
AD  - Department of Pediatrics, Hokkaido University Graduate School of Medicine, 
      Hokkaido, Japan.
FAU - Okamoto, Yasuhiro
AU  - Okamoto Y
AD  - Department of Pediatrics, Kagoshima University Graduate School of Medical and 
      Dental Sciences, Kagoshima, Japan.
LA  - eng
PT  - Journal Article
DEP - 20230410
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
SB  - IM
MH  - Humans
MH  - Child
MH  - Treatment Outcome
MH  - Fusion Proteins, bcr-abl
MH  - *Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
MH  - Retrospective Studies
MH  - East Asian People
MH  - *Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy
MH  - Prognosis
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Remission Induction
MH  - *Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
OTO - NOTNLM
OT  - Acute lymphoblastic leukemia
OT  - Induction failure
OT  - Resistant disease
EDAT- 2023/04/11 06:00
MHDA- 2023/06/23 06:42
CRDT- 2023/04/10 23:21
PHST- 2023/01/23 00:00 [received]
PHST- 2023/04/04 00:00 [accepted]
PHST- 2023/04/03 00:00 [revised]
PHST- 2023/06/23 06:42 [medline]
PHST- 2023/04/11 06:00 [pubmed]
PHST- 2023/04/10 23:21 [entrez]
AID - 10.1007/s12185-023-03600-3 [pii]
AID - 10.1007/s12185-023-03600-3 [doi]
PST - ppublish
SO  - Int J Hematol. 2023 Jul;118(1):99-106. doi: 10.1007/s12185-023-03600-3. Epub 2023 
      Apr 10.