PMID- 37038709
OWN - NLM
STAT- MEDLINE
DCOM- 20240513
LR  - 20240513
IS  - 1875-5666 (Electronic)
IS  - 1566-5240 (Linking)
VI  - 24
IP  - 5
DP  - 2024
TI  - The Preventive Effect of Endostar on Radiation-induced Pulmonary Fibrosis.
PG  - 610-619
LID - 10.2174/1566524023666230406134640 [doi]
AB  - BACKGROUND: Radiation-induced pulmonary fibrosis (RIPF) is a long-term 
      complication of thoracic radiotherapy without effective treatment available. 
      OBJECTIVE: This study aimed to establish a RIPF mouse model and explore the 
      therapeutic effects and mechanisms of recombinant human endostatin (Endostar). 
      METHODS: C57BL/6 mice received a 16-Gy dose of X-rays to the whole thorax with or 
      without the administration of Endostar for 24 weeks. RESULTS: Radiation-induced 
      body weight loss was partially attenuated by Endostar (P<0.05). Endostar 
      significantly reduced alveolar inflammation (P<0.05) and pulmonary fibrosis 
      (P<0.001), as indicated by a decrease in the expression levels of collagen I and 
      collagen IV in lung tissue (both P<0.001). Angiogenesis (as shown by CD31 
      immunohistochemistry) was also decreased (P<0.01). In irradiated mice, Endostar 
      inhibited the transforming growth factor-beta1 (TGF-beta1)/drosophila mothers against 
      the decapentaplegic 3 (Smad3)/extracellular regulated protein kinases (ERK) 
      signaling pathway (all P<0.05). In vitro, Endostar treatment decreased the 
      radiation-induced expression of TGF-beta1, vascular endothelial growth factor 
      (VEGF), p-Smad3, and p-ERK in alveolar epithelial cells and vascular endothelial 
      cells (all P<0.05). CONCLUSION: Endostar could alleviate RIPF through decreased 
      antiangiogenic activity and inhibition of the TGF-beta1/Smad3/ERK pathway.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Ying, Hangjie
AU  - Ying H
AD  - Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer (IBMC), Chinese 
      Academy of Sciences, Hangzhou, Zhejiang, 310022, China.
AD  - Zhejiang Key Laboratory of Radiation Oncology, Zhejiang Cancer Hospital, 
      Hangzhou, Zhejiang 310022, China.
FAU - Zhou, Cheng
AU  - Zhou C
AD  - Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer (IBMC), Chinese 
      Academy of Sciences, Hangzhou, Zhejiang, 310022, China.
FAU - Hang, Qingqing
AU  - Hang Q
AD  - Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer (IBMC), Chinese 
      Academy of Sciences, Hangzhou, Zhejiang, 310022, China.
AD  - The Second Clinical Medical College of Zhejiang Chinese Medical University, 
      Hangzhou, Zhejiang, 310053, China.
FAU - Fang, Min
AU  - Fang M
AD  - Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer (IBMC), Chinese 
      Academy of Sciences, Hangzhou, Zhejiang, 310022, China.
AD  - The Department of Thoracic Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, 
      Zhejiang, 310022, China.
LA  - eng
GR  - 2020KY466, 2021KY084, 2018KY300, 2018KY316)/The Zhejiang Medical and Health 
      Science and Technology Project/
GR  - (No. 81703018)/National Natural Science Foundation of China (NSFC)/
GR  - LY21H160004/Natural Science Foundation of Zhejiang Province/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Curr Mol Med
JT  - Current molecular medicine
JID - 101093076
RN  - 0 (Endostatins)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Transforming Growth Factor beta1)
RN  - GVG18ZDN65 (endostar protein)
RN  - 0 (Smad3 Protein)
RN  - 0 (Smad3 protein, mouse)
SB  - IM
MH  - Animals
MH  - *Endostatins/pharmacology
MH  - Mice
MH  - *Pulmonary Fibrosis/etiology/prevention & control/metabolism/pathology
MH  - *Recombinant Proteins/pharmacology
MH  - *Transforming Growth Factor beta1/metabolism
MH  - Mice, Inbred C57BL
MH  - Smad3 Protein/metabolism
MH  - Humans
MH  - Disease Models, Animal
MH  - MAP Kinase Signaling System/drug effects/radiation effects
MH  - Signal Transduction/drug effects
OTO - NOTNLM
OT  - Endostar
OT  - angiogenesis
OT  - radiation-induced pulmonary fibrosis
OT  - transforming growth factor-beta1.
EDAT- 2023/04/12 06:00
MHDA- 2024/05/13 12:54
CRDT- 2023/04/11 02:24
PHST- 2022/05/25 00:00 [received]
PHST- 2022/12/14 00:00 [revised]
PHST- 2023/01/09 00:00 [accepted]
PHST- 2024/05/13 12:54 [medline]
PHST- 2023/04/12 06:00 [pubmed]
PHST- 2023/04/11 02:24 [entrez]
AID - CMM-EPUB-130755 [pii]
AID - 10.2174/1566524023666230406134640 [doi]
PST - ppublish
SO  - Curr Mol Med. 2024;24(5):610-619. doi: 10.2174/1566524023666230406134640.