PMID- 37039894
OWN - NLM
STAT- MEDLINE
DCOM- 20230731
LR  - 20230916
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 280
IP  - 9
DP  - 2023 Sep
TI  - Association between poly-sensitisation and sensitisation to staphylococcal 
      enterotoxin A and B affecting allergic severity in children.
PG  - 4121-4129
LID - 10.1007/s00405-023-07968-0 [doi]
AB  - PURPOSE: Accumulating evidence suggests that Staphylococcus aureus plays a 
      significant role as a disease modifier in upper and lower airway diseases. We 
      aimed to assess the association between staphylococcal enterotoxins (SEs) with 
      allergic diseases and the degree of allergen sensitisation in children, which 
      remains unclear. METHODS: We retrospectively reviewed the medical records of 455 
      patients aged 3-18 years between March 2018 and March 2022. Clinical history and 
      demographic data were obtained. The baseline study included paranasal sinus X-ray 
      scan, multiple allergen simultaneous test, and ImmunoCAP(R) for measuring serum 
      total and specific immunoglobulin E (IgE) levels to allergens and staphylococcal 
      enterotoxin A and B (SEA and SEB). RESULTS: The mean age was 9.77 +/- 4.3 years. 
      133 patients (29.2%) were sensitised to one inhalant allergen, and 188 patients 
      (41.3%) showed polysensitisation. Patients sensitised to SEs showed higher total 
      and specific IgE levels and total eosinophil counts compared to non-SE-sensitised 
      patients. Sensitisation to SEs is closely associated with polysensitisation to 
      inhalant allergens and allergic multimorbidity. When the SE-IgE value was 0.35 or 
      higher, the odds ratio for allergen polysensitisation was significantly higher 
      than when the SE-IgE value was lower than 0.35. CONCLUSIONS: Association between 
      polysensitisation and sensitisation to SEs in children shows the higher the 
      specific IgE levels for SEs, the higher the likelihood of polysensitisation. 
      Considering the relationship between polysensitisation, high IgE levels, and the 
      severity of allergic morbidity, sensitisation to SEs is thought to be related to 
      allergy severity.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Lee, Young-Ha
AU  - Lee YH
AD  - Department of Otorhinolaryngology, Wonju Severance Christian Hospital, Yonsei 
      University Wonju College of Medicine, 20 Ilsan-ro, Wonju, Gangwon-do, Republic of 
      Korea.
FAU - Kim, Minheon
AU  - Kim M
AD  - Department of Otorhinolaryngology, Wonju Severance Christian Hospital, Yonsei 
      University Wonju College of Medicine, 20 Ilsan-ro, Wonju, Gangwon-do, Republic of 
      Korea.
FAU - Ku, Cheol Hyo
AU  - Ku CH
AD  - Department of Otorhinolaryngology, Wonju Severance Christian Hospital, Yonsei 
      University Wonju College of Medicine, 20 Ilsan-ro, Wonju, Gangwon-do, Republic of 
      Korea.
FAU - Lee, Hyun Su
AU  - Lee HS
AD  - Department of Otorhinolaryngology, Wonju Severance Christian Hospital, Yonsei 
      University Wonju College of Medicine, 20 Ilsan-ro, Wonju, Gangwon-do, Republic of 
      Korea.
FAU - Lee, Joo Hyung
AU  - Lee JH
AD  - Department of Otorhinolaryngology, Wonju Severance Christian Hospital, Yonsei 
      University Wonju College of Medicine, 20 Ilsan-ro, Wonju, Gangwon-do, Republic of 
      Korea.
FAU - Kwon, Dong Hwan
AU  - Kwon DH
AD  - Department of Otorhinolaryngology, Wonju Severance Christian Hospital, Yonsei 
      University Wonju College of Medicine, 20 Ilsan-ro, Wonju, Gangwon-do, Republic of 
      Korea.
FAU - Lee, Eun Jung
AU  - Lee EJ
AUID- ORCID: 0000-0002-0454-4510
AD  - Department of Otorhinolaryngology, Wonju Severance Christian Hospital, Yonsei 
      University Wonju College of Medicine, 20 Ilsan-ro, Wonju, Gangwon-do, Republic of 
      Korea. starlej@yonsei.ac.kr.
LA  - eng
GR  - 2022-52-0054/Yonsei University Wonju College of Medicine/
GR  - NRF-2021R1A2C1010082/Basic Science Research Program of National Research 
      Foundation of Korea/
PT  - Journal Article
DEP - 20230411
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
RN  - 37337-57-8 (enterotoxin A, Staphylococcal)
RN  - 0 (Allergens)
RN  - 0 (Enterotoxins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Humans
MH  - Child
MH  - Child, Preschool
MH  - Adolescent
MH  - Retrospective Studies
MH  - *Hypersensitivity
MH  - Allergens
MH  - Enterotoxins
MH  - Immunoglobulin E
OTO - NOTNLM
OT  - Allergy
OT  - Children
OT  - Enterotoxin
OT  - Severity
OT  - Staphylococcus
EDAT- 2023/04/12 06:00
MHDA- 2023/07/31 06:42
CRDT- 2023/04/11 11:17
PHST- 2023/01/17 00:00 [received]
PHST- 2023/04/03 00:00 [accepted]
PHST- 2023/07/31 06:42 [medline]
PHST- 2023/04/12 06:00 [pubmed]
PHST- 2023/04/11 11:17 [entrez]
AID - 10.1007/s00405-023-07968-0 [pii]
AID - 10.1007/s00405-023-07968-0 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2023 Sep;280(9):4121-4129. doi: 
      10.1007/s00405-023-07968-0. Epub 2023 Apr 11.