PMID- 37039947
OWN - NLM
STAT- MEDLINE
DCOM- 20230522
LR  - 20230522
IS  - 1613-2246 (Electronic)
IS  - 0021-5155 (Linking)
VI  - 67
IP  - 3
DP  - 2023 May
TI  - Evaluation of the lamina cribrosa in different stages of diabetic retinopathy.
PG  - 280-286
LID - 10.1007/s10384-023-00987-8 [doi]
AB  - PURPOSE: To evaluate the relationship of the peripapillary retina nerve fiber 
      layer (RNFL) and lamina cribrosa (LC) with diabetic retinopathy (DR) in type 2 
      diabetes mellitus (DM) cases. STUDY DESIGN: Prospective comparative study. 
      METHODS: This study included 50 non-DR (Group 1), 55 non-proliferative diabetic 
      retinopathy (NPDR) (Group 2), 28 DM cases with proliferative diabetic retinopathy 
      (PDR) (Group 3) and 45 healthy volunteers (Group 4). All participants were 
      evaluated with visual acuity, intraocular pressure (IOP) with Goldman applanation 
      tonometry, anterior segment biomicroscopy, 24 - 2 visual field testing, and 
      dilated fundus examination. Retinal nerve fiber layer (RNFL) thickness, lamina 
      cribrosa thickness (LCT) and anterior lamina cribrosa depth (ALCD) were examined 
      by spectral-domain optical coherence tomography (OCT). RESULTS: There was no 
      difference between the groups in terms of age and gender. Visual acuity 
      (p < 0.001) was significantly different between the groups, while IOP (p = 0.068) 
      was similar. Mean (p = 0.010), superior-temporal (p = 0.024), and superior-nasal 
      (p = 0.011) RNFL thickness decreased significantly in correlation with the stage 
      of DR. LCT decreased significantly as the stage of DR progressed in both vertical 
      and horizontal radial OCT scans (p < 0.001). ALCD was not different between 
      groups (p = 0.954 for horizontal scan, p = 0.867 for vertical scan). CONCLUSION: 
      Peripapillary RNFL and LCT significantly decreases as the DR stage progresses. 
      The biomechanical effects of the LC may also be responsible for diabetes-induced 
      neurodegeneration.
CI  - (c) 2023. Japanese Ophthalmological Society.
FAU - Koca, Semra
AU  - Koca S
AD  - Department of Ophthalmology, Kayseri City Education and Research Hospital, 
      Kayseri, Turkey. drsemrakara68@hotmail.com.
FAU - Vural, Esra
AU  - Vural E
AD  - Department of Ophthalmology, Basaksehir Cam and Sakura City Hospital, Istanbul, 
      Turkey.
FAU - Sirakaya, Ender
AU  - Sirakaya E
AD  - Department of Ophthalmology, Kayseri City Education and Research Hospital, 
      Kayseri, Turkey.
FAU - Kilic, Deniz
AU  - Kilic D
AD  - Department of Ophthalmology, Kayseri City Education and Research Hospital, 
      Kayseri, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20230411
PL  - Japan
TA  - Jpn J Ophthalmol
JT  - Japanese journal of ophthalmology
JID - 0044652
SB  - IM
MH  - Humans
MH  - *Diabetic Retinopathy/complications/diagnosis
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis
MH  - Prospective Studies
MH  - Retina
MH  - Intraocular Pressure
MH  - Tomography, Optical Coherence/methods
OTO - NOTNLM
OT  - Diabetic retinopathy
OT  - Lamina cribrosa
OT  - Neurodegeneration
OT  - Optical coherence tomography
OT  - Retinal nerve fiber layer
EDAT- 2023/04/12 06:00
MHDA- 2023/05/22 06:42
CRDT- 2023/04/11 11:21
PHST- 2022/08/09 00:00 [received]
PHST- 2023/02/24 00:00 [accepted]
PHST- 2023/05/22 06:42 [medline]
PHST- 2023/04/12 06:00 [pubmed]
PHST- 2023/04/11 11:21 [entrez]
AID - 10.1007/s10384-023-00987-8 [pii]
AID - 10.1007/s10384-023-00987-8 [doi]
PST - ppublish
SO  - Jpn J Ophthalmol. 2023 May;67(3):280-286. doi: 10.1007/s10384-023-00987-8. Epub 
      2023 Apr 11.