PMID- 37040388
OWN - NLM
STAT- MEDLINE
DCOM- 20230720
LR  - 20240206
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 228
IP  - 2
DP  - 2023 Jul 14
TI  - Mycobacterial Immune Reconstitution Inflammatory Syndrome in HIV is Associated 
      With Protein-Altering Variants in Hemophagocytic Lymphohistiocytosis-Related 
      Genes.
PG  - 111-115
LID - 10.1093/infdis/jiad059 [doi]
AB  - People with HIV (PWH) and mycobacterial infections can develop immune 
      reconstitution inflammatory syndrome (IRIS) after starting antiretroviral 
      therapy. The pathophysiology of mycobacterial-IRIS overlaps with primary 
      hemophagocytic lymphohistiocytosis (pHLH). To assess possible genetic 
      predisposition to IRIS, protein-altering variants in genes associated with HLH 
      were evaluated in 82 PWH and mycobacterial infections who developed IRIS (n = 56) 
      or did not develop IRIS (n = 26). Protein-altering variants in cytotoxicity genes 
      were found in 23.2% of IRIS patients compared to only 3.8% of those without IRIS. 
      These findings suggest a possible genetic component in the risk of mycobacterial 
      IRIS in PWH. Clinical Trials Registration. NCT00286767, NCT02147405.
CI  - Published by Oxford University Press on behalf of Infectious Diseases Society of 
      America 2023.
FAU - Rocco, Joseph M
AU  - Rocco JM
AUID- ORCID: 0000-0003-4307-4934
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Laidlaw, Elizabeth
AU  - Laidlaw E
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Galindo, Frances
AU  - Galindo F
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Anderson, Megan
AU  - Anderson M
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Sortino, Ornella
AU  - Sortino O
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Kuriakose, Safia
AU  - Kuriakose S
AD  - Clinical Research Directorate, Frederick National Laboratory for Cancer Research, 
      Bethesda, Maryland, USA.
FAU - Lisco, Andrea
AU  - Lisco A
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Manion, Maura
AU  - Manion M
AUID- ORCID: 0000-0003-0991-0011
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Sereti, Irini
AU  - Sereti I
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
LA  - eng
SI  - ClinicalTrials.gov/NCT00286767
SI  - ClinicalTrials.gov/NCT02147405
GR  - NH/NIH HHS/United States
GR  - NH/NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
SB  - IM
CIN - J Infect Dis. 2023 Jul 14;228(2):106-110. PMID: 37040572
MH  - Humans
MH  - *HIV Infections/complications/drug therapy
MH  - *Immune Reconstitution Inflammatory Syndrome
MH  - *Lymphohistiocytosis, Hemophagocytic/genetics/complications
MH  - *Tuberculosis/complications/genetics/drug therapy
PMC - PMC10345459
OTO - NOTNLM
OT  - genetics
OT  - hemophagocytic lymphohistiocytosis
OT  - immune reconstitution inflammatory syndrome
OT  - mycobacteria
OT  - tuberculosis
COIS- Potential conflicts of interest. All authors: No reported conflicts of interest. 
      All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts 
      of Interest. Conflicts that the editors consider relevant to the content of the 
      manuscript have been disclosed.
EDAT- 2023/04/12 06:00
MHDA- 2023/07/17 06:42
PMCR- 2023/04/11
CRDT- 2023/04/11 13:35
PHST- 2022/11/29 00:00 [received]
PHST- 2023/03/03 00:00 [accepted]
PHST- 2023/07/17 06:42 [medline]
PHST- 2023/04/12 06:00 [pubmed]
PHST- 2023/04/11 13:35 [entrez]
PHST- 2023/04/11 00:00 [pmc-release]
AID - 7114708 [pii]
AID - jiad059 [pii]
AID - 10.1093/infdis/jiad059 [doi]
PST - ppublish
SO  - J Infect Dis. 2023 Jul 14;228(2):111-115. doi: 10.1093/infdis/jiad059.