PMID- 37040860
OWN - NLM
STAT- MEDLINE
DCOM- 20230814
LR  - 20230816
IS  - 1557-3117 (Electronic)
IS  - 1053-2498 (Linking)
VI  - 42
IP  - 9
DP  - 2023 Sep
TI  - Impact of adverse events on health-related quality of life after left ventricular 
      assist device implantation: An STS INTERMACS analysis.
PG  - 1214-1222
LID - S1053-2498(23)01818-1 [pii]
LID - 10.1016/j.healun.2023.04.001 [doi]
AB  - BACKGROUND: We sought to quantify the impact of pre- and postoperative variables 
      on health-related quality of life (HRQOL) after left ventricular assist device 
      (LVAD) implantation. METHODS: Primary durable LVAD implants between 2012 and 2019 
      in the Interagency Registry for Mechanically Assisted Circulatory Support were 
      identified. Multivariable modeling using general linear models assessed the 
      impact of baseline characteristics and postimplant adverse events (AEs) on HRQOL 
      as assessed by the EQ-5D visual analog scale (VAS) and the Kansas City 
      Cardiomyopathy Questionnaire-12 (KCCQ) at 6 months and 3 years. RESULTS: Of 
      22,230 patients, 9,888 had VAS and 10,552 had KCCQ reported at 6 months, and 
      2,170 patients had VAS and 2,355 had KCCQ reported at 3 years postimplant. VAS 
      improved from a mean of 38.2 +/- 28.3 to 70.7 +/- 22.9 at 6 months and from 40.1 +/- 
      27.8 to 70.3 +/- 23.1 at 3 years. KCCQ improved from 28.2 +/- 23.9 to 64.3 +/- 23.2 at 
      6 months and from 29.8 +/- 23.7 to 63.0 +/- 23.7 at 3 years. Preimplant variables, 
      including baseline VAS, had small effect sizes on HRQOL while postimplant AEs had 
      large negative effect sizes. Recent stroke, respiratory failure, and renal 
      dysfunction had the largest negative effect on HRQOL at 6 months, while recent 
      renal dysfunction, respiratory failure, and infection had the largest negative 
      effect at 3 years. CONCLUSIONS: AEs following LVAD implantation have large 
      negative effects on HRQOL in early and late follow-up. Understanding the impact 
      of AEs on HRQOL may assist shared decision-making regarding LVAD eligibility. 
      Continued efforts to reduce post-LVAD AEs are warranted to improve HRQOL in 
      addition to survival.
CI  - Copyright (c) 2023 International Society for Heart and Lung Transplantation. 
      Published by Elsevier Inc. All rights reserved.
FAU - Kilic, Arman
AU  - Kilic A
AD  - Division of Cardiothoracic Surgery, Medical University of South Carolina, 
      Charleston, South Carolina. Electronic address: kilica@musc.edu.
FAU - Kwon, Jennie H
AU  - Kwon JH
AD  - Division of Cardiothoracic Surgery, Medical University of South Carolina, 
      Charleston, South Carolina.
FAU - Grady, Kathleen L
AU  - Grady KL
AD  - Departments of Surgery and Medicine. Northwestern University, Chicago, Illinois.
FAU - Singletary, Brandon A
AU  - Singletary BA
AD  - Kirklin Institute for Research in Surgical Outcomes, University of Alabama at 
      Birmingham, Birmingham, Alabama.
FAU - Kilic, Ahmet
AU  - Kilic A
AD  - Division of Cardiac Surgery, Johns Hopkins University, Baltimore, Maryland.
FAU - Everitt, Melanie
AU  - Everitt M
AD  - Department of Pediatrics, University of Colorado, Aurora, Colorado.
FAU - Cleveland, Joseph
AU  - Cleveland J
AD  - Division of Cardiothoracic Surgery, University of Colorado, Aurora, Colorado.
FAU - Cantor, Ryan S
AU  - Cantor RS
AD  - Kirklin Institute for Research in Surgical Outcomes, University of Alabama at 
      Birmingham, Birmingham, Alabama.
FAU - Blackmon, Shanda
AU  - Blackmon S
AD  - Division of Thoracic Surgery, Mayo Clinic, Rochester, Minnesota.
FAU - Breathett, Khadijah
AU  - Breathett K
AD  - Division of Cardiovascular Medicine, Indiana University, Indianapolis, Indiana.
FAU - McKellar, Stephen
AU  - McKellar S
AD  - Division of Cardiovascular and Thoracic Surgery, Intermountain Medical Center, 
      Murray, Utah.
FAU - Keebler, Mary
AU  - Keebler M
AD  - Division of Cardiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
FAU - Kirklin, James K
AU  - Kirklin JK
AD  - Kirklin Institute for Research in Surgical Outcomes, University of Alabama at 
      Birmingham, Birmingham, Alabama.
FAU - Stehlik, Josef
AU  - Stehlik J
AD  - Division of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah.
LA  - eng
PT  - Journal Article
DEP - 20230409
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the 
      International Society for Heart Transplantation
JID - 9102703
SB  - IM
MH  - Humans
MH  - Quality of Life
MH  - *Heart-Assist Devices/adverse effects
MH  - *Heart Failure/surgery
MH  - Registries
MH  - *Respiratory Insufficiency
MH  - *Kidney Diseases
MH  - Treatment Outcome
OTO - NOTNLM
OT  - left ventricular assist device
OT  - outcomes
OT  - quality metrics
OT  - quality of life
EDAT- 2023/04/12 06:00
MHDA- 2023/08/14 06:42
CRDT- 2023/04/11 19:15
PHST- 2022/09/02 00:00 [received]
PHST- 2023/03/09 00:00 [revised]
PHST- 2023/04/03 00:00 [accepted]
PHST- 2023/08/14 06:42 [medline]
PHST- 2023/04/12 06:00 [pubmed]
PHST- 2023/04/11 19:15 [entrez]
AID - S1053-2498(23)01818-1 [pii]
AID - 10.1016/j.healun.2023.04.001 [doi]
PST - ppublish
SO  - J Heart Lung Transplant. 2023 Sep;42(9):1214-1222. doi: 
      10.1016/j.healun.2023.04.001. Epub 2023 Apr 9.