PMID- 37041534
OWN - NLM
STAT- MEDLINE
DCOM- 20230413
LR  - 20230415
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 23
IP  - 1
DP  - 2023 Apr 11
TI  - The association between fatty liver index and onset of diabetes: secondary 
      analysis of a population-based cohort study.
PG  - 679
LID - 10.1186/s12889-023-15442-z [doi]
LID - 679
AB  - BACKGROUND: According to research, the fatty liver index (FLI) is associated with 
      diabetes. However, few studies have been conducted to investigate the 
      relationship between FLI and diabetes risk from various perspectives. This study 
      comprehensively investigated the relationship between FLI and incident diabetes 
      in a large Japanese population. METHODS: This retrospective cohort study included 
      14,280 participants from Murakami Memorial Hospital in Japan from 2004 to 2015. 
      The independent and dependent variables are FLI and risk of type 2 diabetes 
      mellitus (T2DM), respectively. To examine the link between FLI and incident T2DM, 
      Cox proportional-hazards regression was employed. In addition, we performed a 
      number of sensitivity studies to guarantee the validity of the results. Moreover, 
      we conducted subgroup analyses. RESULTS: After adjusting covariates, the results 
      showed that FLI was positively associated with the risk of T2DM (HR = 1.019, 
      95%CI: 1.012, 1.025). Additionally, the sensitivity analysis showed how reliable 
      the outcomes were. And a stronger association between FLI and incident T2DM was 
      observed in the regular exercisers (HR = 1.036, 95%CI: 1.019-1.053, P < 0.0001) 
      and the population without ethanol consumption (HR = 1.028, 95%CI: 1.017-1.039, 
      P < 0.0001). Besides, receiver operating characteristic (ROC) curve analysis 
      showed that FLI was better than waist circumference, triglycerides, body mass 
      index, and gamma-glutamyl transferase in predicting incident T2DM. CONCLUSION: 
      FLI is positively associated with incident T2DM.
CI  - (c) 2023. The Author(s).
FAU - Zhu, Yanqiong
AU  - Zhu Y
AD  - Department of Gastroenterology, Jiangmen Central Hospital, No.23 Haibang Street, 
      Pengjiang District, Jiangmen, 529030, Guangdong Province, China.
FAU - Hu, Haofei
AU  - Hu H
AD  - Department of Nephrology, The First Affiliated Hospital of Shenzhen University, 
      Shenzhen, 518000, Guangdong Province, China.
AD  - Department of Nephrology, Shenzhen Second People's Hospital, Shenzhen, 518000, 
      Guangdong Province, China.
AD  - Shenzhen University Health Science Center, Shenzhen, 518000, Guangdong Province, 
      China.
FAU - Wu, Yumei
AU  - Wu Y
AD  - Department of Gastroenterology, Shenzhen Third People's Hospital, No.29 Bulan 
      Road, Longgang District, Shenzhen, 518000, Guangdong Province, China.
FAU - Rao, Yinhua
AU  - Rao Y
AD  - Department of Gastroenterology, Shenzhen People's Hospital Longhua Branch, 
      Guangdong Province, 518000, China.
FAU - Li, Qixiang
AU  - Li Q
AD  - Department of Gastroenterology, Jiangmen Central Hospital, No.23 Haibang Street, 
      Pengjiang District, Jiangmen, 529030, Guangdong Province, China.
FAU - Duan, Xuehui
AU  - Duan X
AD  - Department of Gastroenterology, Jiangmen Central Hospital, No.23 Haibang Street, 
      Pengjiang District, Jiangmen, 529030, Guangdong Province, China.
FAU - Yao, Guopeng
AU  - Yao G
AD  - Department of Gastroenterology, Jiangmen Central Hospital, No.23 Haibang Street, 
      Pengjiang District, Jiangmen, 529030, Guangdong Province, China.
FAU - Yin, Hekun
AU  - Yin H
AD  - Department of Gastroenterology, Jiangmen Central Hospital, No.23 Haibang Street, 
      Pengjiang District, Jiangmen, 529030, Guangdong Province, China. 
      hekunyin@163.com.
FAU - Luo, Ziyi
AU  - Luo Z
AD  - Department of Gastroenterology, Shenzhen Third People's Hospital, No.29 Bulan 
      Road, Longgang District, Shenzhen, 518000, Guangdong Province, China. 
      1731360398@qq.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230411
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - *Fatty Liver/complications/epidemiology
MH  - Cohort Studies
MH  - Retrospective Studies
MH  - ROC Curve
PMC - PMC10091632
OTO - NOTNLM
OT  - Association
OT  - Fatty liver index
OT  - Incident diabetes
COIS- The authors declare that they have no competing interests.
EDAT- 2023/04/12 06:00
MHDA- 2023/04/13 06:42
PMCR- 2023/04/11
CRDT- 2023/04/11 23:35
PHST- 2022/08/21 00:00 [received]
PHST- 2023/03/14 00:00 [accepted]
PHST- 2023/04/13 06:42 [medline]
PHST- 2023/04/11 23:35 [entrez]
PHST- 2023/04/12 06:00 [pubmed]
PHST- 2023/04/11 00:00 [pmc-release]
AID - 10.1186/s12889-023-15442-z [pii]
AID - 15442 [pii]
AID - 10.1186/s12889-023-15442-z [doi]
PST - epublish
SO  - BMC Public Health. 2023 Apr 11;23(1):679. doi: 10.1186/s12889-023-15442-z.