PMID- 37041790
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230413
IS  - 2008-9783 (Print)
IS  - 2228-6721 (Electronic)
IS  - 2008-9783 (Linking)
VI  - 13
DP  - 2022
TI  - Transcranial Infrared Laser Stimulation for the Treatment of Traumatic Brain 
      Injury: A Case Series.
PG  - e65
LID - 10.34172/jlms.2022.65 [doi]
LID - e65
AB  - Introduction: This study intended to evaluate the safety and possible therapeutic 
      effect of transcranial infrared laser stimulation (TILS) based on 
      photobiomodulation (PBM) among patients with traumatic brain injury (TBI). 
      Methods: Eleven participants who were diagnosed with TBI after full neurological 
      examination and MRI evaluation by a board-certified neurologist completed five to 
      eight 20-minute TILS sessions using the Cytonsys CytonPro-5000 apparatus (pilot 
      laser control, focused wavelength of 1064 nm, maximum output power of 10W, 
      maximum optical power density of 500 mW/cm(2), effective area 4.5 cm(2) in 
      diameter). Per TILS session, participants underwent a laser dose of 250 mW/cm(2) 
      continuous laser wave to each hemisphere using predetermined patient-specific 
      coordinates. Structural imaging was used to neuronavigate individual treatment 
      targets in the frontal cortex (Brodmann area 10). The primary safety measure for 
      this study was the occurrence of adverse events (AEs) or serious adverse events 
      (SAEs). The primary efficacy outcome measure was the participant-rated global 
      rating of change (GRC) post-intervention. Secondary outcome measures included a 
      battery of neuropsychological testing and mood questionnaires done both pre- and 
      post-intervention. Results: All patients enrolled in this study protocol were 
      able to tolerate the study procedures without any AEs or SAEs. Nine out of eleven 
      participants had clinically significant improvements in GRC score (>/= +2). 
      Neuropsychological testing and mood questionnaire outcomes also suggested a 
      positive therapeutic effect. Conclusion: This study provides preliminary evidence 
      supporting the safety and potential efficacy of TILS as a non-invasive clinical 
      intervention for individuals with TBI.
CI  - Copyright (c) 2022 J Lasers Med Sci.
FAU - Rindner, Elisabeth S
AU  - Rindner ES
AD  - The Regenesis Project, Los Angeles, CA, USA.
FAU - Haroon, Jonathan M
AU  - Haroon JM
AD  - The Regenesis Project, Los Angeles, CA, USA.
FAU - Jordan, Kaya G
AU  - Jordan KG
AD  - The Regenesis Project, Los Angeles, CA, USA.
FAU - Mahdavi, Kennedy D
AU  - Mahdavi KD
AD  - The Regenesis Project, Los Angeles, CA, USA.
FAU - Surya, Jean R
AU  - Surya JR
AD  - The Regenesis Project, Los Angeles, CA, USA.
FAU - Zielinski, Margaret A
AU  - Zielinski MA
AD  - The Regenesis Project, Los Angeles, CA, USA.
FAU - Habelhah, Barshen
AU  - Habelhah B
AD  - The Regenesis Project, Los Angeles, CA, USA.
FAU - Venkatraman, Victoria
AU  - Venkatraman V
AD  - The Regenesis Project, Los Angeles, CA, USA.
FAU - Becerra, Sergio A
AU  - Becerra SA
AD  - Synaptec Network, Los Angeles, CA, USA.
FAU - Chan, Lider
AU  - Chan L
AD  - Orthopedic Physical Therapy Associates, Los Angeles, CA, USA.
FAU - Kuhn, Taylor P
AU  - Kuhn TP
AD  - Department of Psychiatry and Biobehavioral Sciences, University of California, 
      Los Angeles, CA, USA.
FAU - Jordan, Sheldon E
AU  - Jordan SE
AD  - The Regenesis Project, Los Angeles, CA, USA.
AD  - Department of Neurology, University of California, Los Angeles, CA, USA.
LA  - eng
PT  - Case Reports
DEP - 20221213
PL  - Iran
TA  - J Lasers Med Sci
JT  - Journal of lasers in medical sciences
JID - 101580415
PMC - PMC10082915
OTO - NOTNLM
OT  - Brain stimulation
OT  - Near infrared light therapy
OT  - Transcranial infrared laser stimulation
OT  - Traumatic brain injury
COIS- We have no conflict of interest to disclose.
EDAT- 2023/04/13 06:00
MHDA- 2023/04/13 06:01
PMCR- 2022/12/13
CRDT- 2023/04/12 01:43
PHST- 2022/10/12 00:00 [received]
PHST- 2022/12/10 00:00 [accepted]
PHST- 2023/04/13 06:01 [medline]
PHST- 2023/04/12 01:43 [entrez]
PHST- 2023/04/13 06:00 [pubmed]
PHST- 2022/12/13 00:00 [pmc-release]
AID - 10.34172/jlms.2022.65 [doi]
PST - epublish
SO  - J Lasers Med Sci. 2022 Dec 13;13:e65. doi: 10.34172/jlms.2022.65. eCollection 
      2022.