PMID- 37044184 OWN - NLM STAT- MEDLINE DCOM- 20230515 LR - 20230515 IS - 1879-0038 (Electronic) IS - 0378-1119 (Linking) VI - 870 DP - 2023 Jun 20 TI - Pinellia genus: A systematic review of active ingredients, pharmacological effects and action mechanism, toxicological evaluation, and multi-omics application. PG - 147426 LID - S0378-1119(23)00267-6 [pii] LID - 10.1016/j.gene.2023.147426 [doi] AB - The dried tuber of Pinellia ternata (Thunb.) Breit, Pinelliae Rhizoma (PR, also named 'Banxia' in Chinese), is widely used in traditional medicine. This review aims to provide detail summary of active ingredients, pharmacological effects, toxic ingredients, detoxification strategies, and omic researches, etc. Pharmacological ingredients from PR are mainly classified into six categories: alkaloids, amino acids, polysaccharides, phenylpropanoids, essential oils, and glucocerebrosides. Diversity of chemical composition determines the broad-spectrum efficacy and gives a foundation for the comprehensive utilization of P. ternata germplasm resources. The pharmacological compounds are involved in inhibition of cancer cells by targeting various pathways, including activation of immune system, inhibition of proliferation and cycle, induction of apoptosis, and inhibition of angiogenesis. The pharmacological components of PR act on nervous system by targeting neurotransmitters, activating immune system, decreasing apoptosis, and increasing redox system. Lectins, one major class of the toxic ingredients extracted from raw PR, possess significant toxic effects on human cells. Inflammatory factors, cytochrome P450 proteins (CYP) family enzymes, mammalian target of rapamycin (mTOR) signaling factors, transforming growth factor-beta (TGF-beta) signaling factors, and nervous system, are considered to be the target sites of lectins. Recently, omic analysis is widely applied in Pinellia genus studies. Plastome genome-based molecular markers are deeply used for identifying and resolving phylogeny of Pinellia genus plants. Various omic works revealed and functional identified a series of environmental stress responsive factors and active component biosynthesis-related genes. Our review summarizes the recent progress in active and toxic ingredient evaluation, pharmacological effects, detoxification strategies, and functional gene identification and accelerates efficient utilization of this traditional herb. CI - Copyright (c) 2023 Elsevier B.V. All rights reserved. FAU - Chen, Cheng AU - Chen C AD - School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China. FAU - Sun, Yunting AU - Sun Y AD - Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang 311121, China. Electronic address: syt182@163.com. FAU - Wang, Zhijing AU - Wang Z AD - School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China. FAU - Huang, Zhihua AU - Huang Z AD - School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China. FAU - Zou, Yuqing AU - Zou Y AD - School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China. FAU - Yang, Feifei AU - Yang F AD - School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China. FAU - Hu, Jing AU - Hu J AD - School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China. FAU - Cheng, Huijuan AU - Cheng H AD - School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China. FAU - Shen, Chenjia AU - Shen C AD - College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 311121, China. Electronic address: shencj@hznu.edu.cn. FAU - Wang, Shuling AU - Wang S AD - School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China. Electronic address: wsling222@163.com. LA - eng PT - Journal Article PT - Systematic Review DEP - 20230410 PL - Netherlands TA - Gene JT - Gene JID - 7706761 RN - 0 (Drugs, Chinese Herbal) RN - 0 (Alkaloids) RN - 0 (Lectins) SB - IM MH - Humans MH - *Drugs, Chinese Herbal/pharmacology MH - *Pinellia/chemistry MH - Multiomics MH - *Alkaloids MH - Lectins OTO - NOTNLM OT - Active ingredient OT - Cytotoxicity OT - Omics OT - Pharmacological characteristic OT - Pinellia ternata COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/04/13 06:00 MHDA- 2023/05/15 06:42 CRDT- 2023/04/12 19:22 PHST- 2023/02/20 00:00 [received] PHST- 2023/04/05 00:00 [revised] PHST- 2023/04/07 00:00 [accepted] PHST- 2023/05/15 06:42 [medline] PHST- 2023/04/13 06:00 [pubmed] PHST- 2023/04/12 19:22 [entrez] AID - S0378-1119(23)00267-6 [pii] AID - 10.1016/j.gene.2023.147426 [doi] PST - ppublish SO - Gene. 2023 Jun 20;870:147426. doi: 10.1016/j.gene.2023.147426. Epub 2023 Apr 10.