PMID- 37044299 OWN - NLM STAT- MEDLINE DCOM- 20230522 LR - 20230522 IS - 1873-2968 (Electronic) IS - 0006-2952 (Linking) VI - 212 DP - 2023 Jun TI - The role of small intestinal bacterial overgrowth in obesity and its related diseases. PG - 115546 LID - S0006-2952(23)00137-5 [pii] LID - 10.1016/j.bcp.2023.115546 [doi] AB - Obesity has become a major public health problem worldwide and its occurrence is increasing globally. Obesity has also been shown to be involved in the occurrence and development of many diseases and pathological conditions, such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes mellitus (T2DM), insulin resistance (IR). In recent years, gut microbiota has received extensive attention as an important regulatory part involved in host diseases and health status. A growing body of evidence suggests that gut microbiota dysbiosis has a significant adverse effect on the host. Small intestinal bacterial overgrowth (SIBO), a type of intestinal microbial dysbiosis, has been gradually revealed to be associated with obesity and its related diseases. The presence of SIBO may lead to the destruction of intestinal barrier integrity, increased intestinal permeability, increased endotoxin levels, activation of inflammatory responses, and translocation of bacteria from the colon to the small intestine. However, the causal relationship between SIBO and obesity and the specific mechanisms have not been well elucidated. This review discusses the cross-talk between SIBO and obesity and its related diseases, and expounds its potential mechanisms and interventions, which may help to discover new therapeutic targets for obesity and its related diseases and develop treatment options. CI - Copyright (c) 2023 Elsevier Inc. All rights reserved. FAU - Yao, Qinyan AU - Yao Q AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China; Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China. FAU - Yu, Zihan AU - Yu Z AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China; Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China. FAU - Meng, Qingguo AU - Meng Q AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China; Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China. FAU - Chen, Jihua AU - Chen J AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China; Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China. FAU - Liu, Yaxin AU - Liu Y AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China; Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China. FAU - Song, Wenxuan AU - Song W AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China; Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China. FAU - Ren, Xiangfeng AU - Ren X AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China; Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China. FAU - Zhou, Jinjie AU - Zhou J AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China; Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China. FAU - Chen, Xin AU - Chen X AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China; Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China. Electronic address: xchen03@tmu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20230410 PL - England TA - Biochem Pharmacol JT - Biochemical pharmacology JID - 0101032 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2 MH - Dysbiosis/complications MH - Obesity/complications MH - *Non-alcoholic Fatty Liver Disease/drug therapy MH - Intestines/microbiology OTO - NOTNLM OT - Gut microbiota OT - Nonalcoholic fatty liver disease OT - Obesity OT - Small intestinal bacterial overgrowth OT - Type 2 diabetes mellitus COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/04/13 06:00 MHDA- 2023/05/22 06:42 CRDT- 2023/04/12 19:25 PHST- 2023/02/25 00:00 [received] PHST- 2023/03/31 00:00 [revised] PHST- 2023/04/04 00:00 [accepted] PHST- 2023/05/22 06:42 [medline] PHST- 2023/04/13 06:00 [pubmed] PHST- 2023/04/12 19:25 [entrez] AID - S0006-2952(23)00137-5 [pii] AID - 10.1016/j.bcp.2023.115546 [doi] PST - ppublish SO - Biochem Pharmacol. 2023 Jun;212:115546. doi: 10.1016/j.bcp.2023.115546. Epub 2023 Apr 10.