PMID- 37044367 OWN - NLM STAT- MEDLINE DCOM- 20230501 LR - 20230503 IS - 1532-3064 (Electronic) IS - 0954-6111 (Linking) VI - 212 DP - 2023 Jun TI - Association of intrinsic capacity with respiratory disease mortality. PG - 107243 LID - S0954-6111(23)00131-2 [pii] LID - 10.1016/j.rmed.2023.107243 [doi] AB - The World Health Organization (WHO) introduced a framework for healthy aging in 2015 that emphasizes functional ability instead of absence of disease. Healthy ageing is defined as "the process of building and maintaining the functional ability that enables well-being". This framework considers an individual's intrinsic capacity (IC), environment, and the interaction between them to determine functional ability. In this prospective cohort study, we investigated the link between mortality and various respiratory diseases in almost half a million adults who are part of the UK Biobank. We derived an IC score using measures from 4 of the 5 domains: two for psychological capacity, two for sensory capacity, two for vitality and one for locomotor capacity. The exposure variable in the study was the number of reported factors, which was summed and categorized into IC scores of zero, one, two, three, or at least four. The outcome was respiratory disease-related mortality, which was linked to national mortality records. The follow-up period started from participants' inclusion in the UK Biobank study (2006-2010) and ended on December 31, 2021, or the participant's death was censored. The average follow-up was 10.6 years (IQR 10.0; 11.3). During a median follow-up period of 10.6 years, 27,251 deaths were recorded. Out of these, 7.5% (2059) were primarily attributed to respiratory disease. The results showed that a higher IC score (+4 points) was associated with a significantly increased risk of respiratory disease mortality, with HRs of 3.34 [2.64 to 4.23] for men (C-index = 0.83) and 3.87 [2.86 to 5.23] for women (C-index = 0.84), independent of major confounding factors (P < 0.001). Our study provides evidence that lower levels of the WHO's IC construct are associated with increased risk of mortality and various adverse health outcomes. The IC construct, which is easily and inexpensively measured, holds great promise for transforming geriatric care worldwide, including in regions without established geriatric medicine. CI - Copyright (c) 2023 Elsevier Ltd. All rights reserved. FAU - Ramirez-Velez, Robinson AU - Ramirez-Velez R AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de Navarra (UPNA), IdiSNA, Pamplona, Spain; CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: robin640@hotmail.com. FAU - Iriarte-Fernandez, Maria AU - Iriarte-Fernandez M AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de Navarra (UPNA), IdiSNA, Pamplona, Spain. Electronic address: maria.iriarte@outlook.com. FAU - Santafe, Guzman AU - Santafe G AD - Department of Statistics, Computer Science, And Mathematics, Universidad Publica de Navarra (UPNA), Pamplona, Spain; InaMat, Universidad Publica de Navarra (UPNA), Pamplona, Spain. Electronic address: guzman.santafe@unavarra.es. FAU - Malanda, Armando AU - Malanda A AD - Department of Electrical and Electronic Engineering, Universidad Publica de Navarra (UPNA), Pamplona, Spain. Electronic address: malanda@unavarra.es. FAU - Beard, John R AU - Beard JR AD - International Longevity Center USA . Columbia University Mailman School of Public Health, NY, USA. Electronic address: DrJohnBeard@outlook.com. FAU - Garcia-Hermoso, Antonio AU - Garcia-Hermoso A AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de Navarra (UPNA), IdiSNA, Pamplona, Spain. Electronic address: antonio.garciah@unavarra.es. FAU - Izquierdo, Mikel AU - Izquierdo M AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de Navarra (UPNA), IdiSNA, Pamplona, Spain; CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: mikel.izquierdo@gmail.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20230410 PL - England TA - Respir Med JT - Respiratory medicine JID - 8908438 SB - IM MH - Male MH - Adult MH - Humans MH - Female MH - Aged MH - Prospective Studies MH - Risk Factors MH - *Respiratory Tract Diseases MH - *Respiration Disorders MH - Activities of Daily Living COIS- Declaration of competing interest The authors declare no conflict of interest. EDAT- 2023/04/13 06:00 MHDA- 2023/05/01 06:42 CRDT- 2023/04/12 19:26 PHST- 2023/03/15 00:00 [received] PHST- 2023/04/04 00:00 [revised] PHST- 2023/04/05 00:00 [accepted] PHST- 2023/05/01 06:42 [medline] PHST- 2023/04/13 06:00 [pubmed] PHST- 2023/04/12 19:26 [entrez] AID - S0954-6111(23)00131-2 [pii] AID - 10.1016/j.rmed.2023.107243 [doi] PST - ppublish SO - Respir Med. 2023 Jun;212:107243. doi: 10.1016/j.rmed.2023.107243. Epub 2023 Apr 10.