PMID- 37045603
OWN - NLM
STAT- MEDLINE
DCOM- 20230530
LR  - 20230530
IS  - 1745-2422 (Electronic)
IS  - 1743-4440 (Linking)
VI  - 20
IP  - 6
DP  - 2023 Jun
TI  - Meta-analysis of clinical outcomes in cardiac resynchronisation therapy: his 
      bundle pacing vs biventricular pacing.
PG  - 505-515
LID - 10.1080/17434440.2023.2202816 [doi]
AB  - INTRODUCTION AND OBJECTIVE: Cardiac resynchronization may treat severe heart 
      failure (HF) with pharmacological optimization, left branch block, and an 
      ejection fraction<35%. However, 30-40% of patients fail therapy. HBP could 
      replace biventricular pacing (BiV). We compared the effectiveness of HBP versus 
      BiV in HF patients. METHODS: We searched PubMed, Embase, and Cochrane for studies 
      on QRS, left ventricular ejection fraction (LVEF), New York Heart Association 
      (NYHA) functional class, left ventricular end-systolic volume (LVESV), and 
      6-minute walk test. RESULTS: Six publications included 774 patients (mean [+/- 
      standard deviation] age: 66.9 [14.0] years; 484 (62.5%) were males; 408 [52.71%] 
      underwent HBP; the mean follow-up was 6-12 months. The HBP group had a higher QRS 
      reduction in the meta-analysis (median: -17.54 [-20.46, -14.62]; I(2) = 89%). 
      LVEF showed a median of 8.48 (7.55, 9.41) and I(2) of 98%, with a higher mean in 
      HBP. The LVESV median was -18.89 (-30.03, -7.75) and I(2) was 0%, and the HBP 
      group had a lower mean. HBP had a lower NYHA functional class (median= -0.20 
      [-0.28, -0.12]). CONCLUSION: After implantation, HBP demonstrated bigger QRS 
      shortening, increased LVEF, lower LVES volume, and lower NYHA class than BiV 
      pacing.
FAU - da Silva Menezes Junior, Antonio
AU  - da Silva Menezes Junior A
AUID- ORCID: 0000-0003-1751-5206
AD  - Medical and Life School, Pontifical Catholic University of Goias, Goiania, GO, 
      Brazil.
AD  - Faculty of Medicine, Federal University of Goias, Goiania, GO, Brasil.
FAU - Melo, Maria Gabriella Zordan
AU  - Melo MGZ
AUID- ORCID: 0000-0002-6559-6744
AD  - Medical and Life School, Pontifical Catholic University of Goias, Goiania, GO, 
      Brazil.
FAU - Barreto, Lara Pedriel
AU  - Barreto LP
AUID- ORCID: 0000-0003-3524-3830
AD  - Medical and Life School, Pontifical Catholic University of Goias, Goiania, GO, 
      Brazil.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20230414
PL  - England
TA  - Expert Rev Med Devices
JT  - Expert review of medical devices
JID - 101230445
SB  - IM
MH  - Male
MH  - Humans
MH  - Aged
MH  - Female
MH  - *Cardiac Resynchronization Therapy
MH  - Bundle of His
MH  - Stroke Volume
MH  - Bundle-Branch Block/therapy
MH  - Ventricular Function, Left
MH  - Electrocardiography
MH  - Treatment Outcome
MH  - Cardiac Pacing, Artificial
MH  - *Heart Failure
OTO - NOTNLM
OT  - Biventricular pacing
OT  - Hisian pacing
OT  - cardiac resynchronization therapy
OT  - heart failure
OT  - his bundle pacing
OT  - meta-analysis
EDAT- 2023/04/13 06:00
MHDA- 2023/05/30 06:42
CRDT- 2023/04/12 21:41
PHST- 2023/05/30 06:42 [medline]
PHST- 2023/04/13 06:00 [pubmed]
PHST- 2023/04/12 21:41 [entrez]
AID - 10.1080/17434440.2023.2202816 [doi]
PST - ppublish
SO  - Expert Rev Med Devices. 2023 Jun;20(6):505-515. doi: 
      10.1080/17434440.2023.2202816. Epub 2023 Apr 14.