PMID- 37045725
OWN - NLM
STAT- MEDLINE
DCOM- 20230705
LR  - 20230705
IS  - 1579-2129 (Electronic)
IS  - 0300-2896 (Linking)
VI  - 59
IP  - 7
DP  - 2023 Jul
TI  - Estimated Worldwide Prevalence of the PI*ZZ Alpha-1 Antitrypsin Genotype in 
      Subjects With Chronic Obstructive Pulmonary Disease.
PG  - 427-434
LID - S0300-2896(23)00117-5 [pii]
LID - 10.1016/j.arbres.2023.03.016 [doi]
AB  - INTRODUCTION: The prevalence of alpha1-antitrypsin PI*ZZ genotypes in patients with 
      COPD is only partially known. We aimed to estimate this prevalence worldwide. 
      METHOD: A systematic review of the literature was conducted for studies 
      investigating the prevalence of COPD and the prevalence of severe 
      alpha-1-antitrypsin deficiency (AATD) PI*ZZ genotype. Results are shown in tables 
      and on a whole world interpolation map. RESULTS: Studies from 48 countries with 
      available data (21 from Europe, 9 from the Americas, 5 from Africa, 11 from Asia 
      and 2 from Australasia) were selected. About 235,000 individuals with PI*ZZ 
      genotypes were accounted: 50% in Europe, 37% in America, 9% in Asia, 3% in 
      Australasia and 1% in Africa. The estimated crude prevalence of COPD in adults 
      older than 40 years was 12.45% in Europe, 13.51% in America, 13.22% in Africa, 
      11.70% in Asia and 11.86% in Australasia. The highest PI*ZZ weighted average 
      prevalence among COPD subjects (expressed as 1/x [95% confidence intervals]) were 
      found in Northern Europe (395 [252-576]) followed by Western (797 [538-1165]), 
      Southern (944 [600-1475]) and Central Europe (1096 [687-1738]). Outside Europe, 
      high values were found in Australia-New Zealand (1007 [684-1509]), Saudi Arabia 
      (1276 [563-2961]), United States (1298 [1094-1540]), Canada (1482 [1057-2083]) 
      and Thailand (1807 [717-4692]). In the rest of the world, prevalence was 
      significantly lower, especially in vast regions of Asia and Africa where the PI*Z 
      gene is practically non-existent. CONCLUSIONS: Severe AATD is associated with a 
      significant number of cases of COPD, especially in Europe, USA, Canada, New 
      Zealand and Australia.
CI  - Copyright (c) 2023 SEPAR. Published by Elsevier Espana, S.L.U. All rights reserved.
FAU - Blanco, Ignacio
AU  - Blanco I
AD  - Alpha1-Antitrypsin Deficiency Spanish Registry, Spanish Society of Pneumology and 
      Thoracic Surgery (SEPAR), Barcelona, Spain.
FAU - Diego, Isidro
AU  - Diego I
AD  - Materials and Energy Dept, School of Mining Engineering, Oviedo University, 
      Oviedo, Principality of Asturias, Spain.
FAU - Castanon, Cesar
AU  - Castanon C
AD  - Materials and Energy Dept, School of Mining Engineering, Oviedo University, 
      Oviedo, Principality of Asturias, Spain.
FAU - Bueno, Patricia
AU  - Bueno P
AD  - Internal Medicine Dept, County Hospital of Jarrio, Jarrio, Principality of 
      Asturias, Spain.
FAU - Miravitlles, Marc
AU  - Miravitlles M
AD  - Pneumology Dept, Hospital Universitari Vall d'Hebron/Vall d'Hebron Research 
      Institute (VHIR), Barcelona, Catalonia, Spain. Electronic address: 
      marcm@separ.es.
LA  - eng
LA  - spa
PT  - Journal Article
PT  - Review
DEP - 20230330
PL  - Spain
TA  - Arch Bronconeumol
JT  - Archivos de bronconeumologia
JID - 0354720
RN  - 0 (alpha 1-Antitrypsin)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *alpha 1-Antitrypsin Deficiency/epidemiology/genetics/complications
MH  - Prevalence
MH  - alpha 1-Antitrypsin/genetics
MH  - *Pulmonary Disease, Chronic Obstructive/epidemiology/genetics/complications
MH  - Genotype
MH  - Europe/epidemiology
OTO - NOTNLM
OT  - Alpha-1 antitrypsin deficiency
OT  - COPD
OT  - Chronic obstructive pulmonary disease
OT  - Geographic Information Systems (GIS) technology
OT  - Inverse distance weighted (IDW) interpolation
OT  - PI*ZZ genotype
OT  - Prevalence
OT  - SERPINA1
EDAT- 2023/04/13 06:00
MHDA- 2023/07/05 06:42
CRDT- 2023/04/12 22:04
PHST- 2023/02/01 00:00 [received]
PHST- 2023/03/11 00:00 [revised]
PHST- 2023/03/21 00:00 [accepted]
PHST- 2023/07/05 06:42 [medline]
PHST- 2023/04/13 06:00 [pubmed]
PHST- 2023/04/12 22:04 [entrez]
AID - S0300-2896(23)00117-5 [pii]
AID - 10.1016/j.arbres.2023.03.016 [doi]
PST - ppublish
SO  - Arch Bronconeumol. 2023 Jul;59(7):427-434. doi: 10.1016/j.arbres.2023.03.016. 
      Epub 2023 Mar 30.