PMID- 37046898
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230415
IS  - 2227-9032 (Print)
IS  - 2227-9032 (Electronic)
IS  - 2227-9032 (Linking)
VI  - 11
IP  - 7
DP  - 2023 Mar 29
TI  - Laboratory Test Results in Patients with Workplace Moisture Damage Associated 
      Symptoms-The SAMDAW Study.
LID - 10.3390/healthcare11070971 [doi]
LID - 971
AB  - The mechanisms of health effects of moisture damage (MD) are unclear, but 
      inflammatory responses have been suspected. The usefulness of laboratory and 
      allergy tests among patients in secondary healthcare with symptoms associated 
      with workplace MD were examined. Full blood count, erythrocyte sedimentation rate 
      (ESR), C-reactive protein (CRP), total serum immunoglobulin E (IgE), fractional 
      exhaled nitric oxide (FeNO), and skin prick testing were assessed and analyzed in 
      relation to multiple chemical sensitivity (MCS) and perceived stress in 99 
      patients and 48 controls. In analysis, t-tests, Mann-Whitney tests, and 
      chi-squared tests were used. Minor clinically insignificant differences in blood 
      counts were seen in patients and controls, but among patients with asthma an 
      elevated neutrophil count was found in 19% with and only in 2% of patients 
      without asthma (p = 0.003). CRP levels and ESR were low, and the study patients' 
      FeNO, total IgE, or allergic sensitization were not increased compared to 
      controls. The level of stress was high among 26% of patients and 6% of controls 
      (p = 0.005), and MCS was more common among patients (39% vs. 10%, p < 0.001). 
      Stress or MCS were not significantly associated with laboratory test results. In 
      conclusion, no basic laboratory or allergy test results were characteristic of 
      this patient group, and neither inflammatory processes nor allergic sensitization 
      were found to explain the symptoms among these patients. While the value of basic 
      laboratory tests should not be ignored, the use of allergy tests does not seem 
      necessary when symptoms are indicated to be workplace-related.
FAU - Nynas, Pia
AU  - Nynas P
AUID- ORCID: 0000-0002-0704-8862
AD  - Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, 
      Finland.
FAU - Vilpas, Sarkku
AU  - Vilpas S
AD  - Department of Phoniatrics, Tampere University Hospital, 33520 Tampere, Finland.
FAU - Kankare, Elina
AU  - Kankare E
AD  - Department of Phoniatrics, Tampere University Hospital, 33520 Tampere, Finland.
FAU - Karjalainen, Jussi
AU  - Karjalainen J
AD  - Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, 
      Finland.
AD  - Allergy Centre, Tampere University Hospital, 33520 Tampere, Finland.
FAU - Lehtimaki, Lauri
AU  - Lehtimaki L
AUID- ORCID: 0000-0003-1586-4998
AD  - Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, 
      Finland.
AD  - Allergy Centre, Tampere University Hospital, 33520 Tampere, Finland.
FAU - Numminen, Jura
AU  - Numminen J
AD  - Allergy Centre, Tampere University Hospital, 33520 Tampere, Finland.
FAU - Tikkakoski, Antti
AU  - Tikkakoski A
AD  - Department of Clinical Physiology and Nuclear Medicine, Tampere University 
      Hospital, 33520 Tampere, Finland.
FAU - Kleemola, Leenamaija
AU  - Kleemola L
AD  - Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, 
      Finland.
FAU - Uitti, Jukka
AU  - Uitti J
AD  - Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, 
      Finland.
LA  - eng
GR  - N.A./Tampereen Tuberkuloosisaatio/
GR  - 9T069/The Competitive State Research Financing of the Expert Responsibility Area 
      of Tampere University Hospital/
GR  - N.A./The Orion Research Foundation SR/
GR  - N.A./The Research Foundation of the Pulmonary Diseases/
GR  - N.A./The Finnish Medical Foundation/
GR  - N.A./The Finnish ORL-HNS Foundation/
PT  - Journal Article
DEP - 20230329
PL  - Switzerland
TA  - Healthcare (Basel)
JT  - Healthcare (Basel, Switzerland)
JID - 101666525
PMC - PMC10093791
OTO - NOTNLM
OT  - CRP
OT  - FeNO
OT  - IgE
OT  - allergy
OT  - blood count
OT  - dampness
OT  - moisture damage
OT  - mold
OT  - multiple chemical sensitivity
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2023/04/14 06:00
MHDA- 2023/04/14 06:01
PMCR- 2023/03/29
CRDT- 2023/04/13 01:08
PHST- 2023/02/05 00:00 [received]
PHST- 2023/03/25 00:00 [revised]
PHST- 2023/03/28 00:00 [accepted]
PHST- 2023/04/14 06:01 [medline]
PHST- 2023/04/13 01:08 [entrez]
PHST- 2023/04/14 06:00 [pubmed]
PHST- 2023/03/29 00:00 [pmc-release]
AID - healthcare11070971 [pii]
AID - healthcare-11-00971 [pii]
AID - 10.3390/healthcare11070971 [doi]
PST - epublish
SO  - Healthcare (Basel). 2023 Mar 29;11(7):971. doi: 10.3390/healthcare11070971.