PMID- 37047097
OWN - NLM
STAT- MEDLINE
DCOM- 20230415
LR  - 20230415
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 7
DP  - 2023 Mar 24
TI  - The Role of Post-Translational Modifications in Regulation of NLRP3 Inflammasome 
      Activation.
LID - 10.3390/ijms24076126 [doi]
LID - 6126
AB  - Pathogen-associated molecular patterns (PAMPs) and danger-associated molecular 
      patterns (DAMPs) induce NLRP3 inflammasome activation, and subsequent formation 
      of active caspase-1 as well as the maturation of interleukin-1beta (IL-1beta) and 
      gasdermin D (GSDMD), mediating the occurrence of pyroptosis and inflammation. 
      Aberrant NLRP3 inflammasome activation causes a variety of diseases. Therefore, 
      the NLRP3 inflammasome pathway is a target for prevention and treatment of 
      relative diseases. Recent studies have suggested that NLRP3 inflammasome activity 
      is closely associated with its post-translational modifications (PTMs). This 
      review focuses on PTMs of the components of the NLRP3 inflammasome and the 
      resultant effects on regulation of its activity to provide references for the 
      exploration of the mechanisms by which the NLRP3 inflammasome is activated and 
      controlled.
FAU - Xia, Jing
AU  - Xia J
AD  - College of Veterinary Medicine, Southwest University, Chongqing 402460, China.
FAU - Jiang, Songhong
AU  - Jiang S
AD  - College of Veterinary Medicine, Southwest University, Chongqing 402460, China.
FAU - Dong, Shiqi
AU  - Dong S
AD  - College of Veterinary Medicine, Southwest University, Chongqing 402460, China.
FAU - Liao, Yonghong
AU  - Liao Y
AD  - College of Veterinary Medicine, Southwest University, Chongqing 402460, China.
AD  - National Center of Technology Innovation for Pigs, Chongqing 402460, China.
FAU - Zhou, Yang
AU  - Zhou Y
AUID- ORCID: 0000-0002-9087-0522
AD  - College of Veterinary Medicine, Southwest University, Chongqing 402460, China.
AD  - National Center of Technology Innovation for Pigs, Chongqing 402460, China.
LA  - eng
GR  - NCTIP-XD/B11/National Center of Technology Innovation for Pigs/
GR  - SWU020020 and SWU-KT22012/Fundamental Research Funds for the Central 
      Universities/
PT  - Journal Article
PT  - Review
DEP - 20230324
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - EC 3.4.22.36 (Caspase 1)
RN  - 0 (Inflammasomes)
RN  - 0 (Interleukin-1beta)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (NLRP3 protein, human)
SB  - IM
MH  - Caspase 1/metabolism
MH  - *Inflammasomes/metabolism
MH  - Interleukin-1beta/metabolism
MH  - *NLR Family, Pyrin Domain-Containing 3 Protein/metabolism
MH  - Protein Processing, Post-Translational
MH  - Pyroptosis/physiology
MH  - Humans
PMC - PMC10093848
OTO - NOTNLM
OT  - NLRP3
OT  - inflammasome
OT  - post-translational modification
COIS- The authors declare no conflict of interest.
EDAT- 2023/04/14 06:00
MHDA- 2023/04/14 06:41
PMCR- 2023/03/24
CRDT- 2023/04/13 01:10
PHST- 2023/02/22 00:00 [received]
PHST- 2023/03/16 00:00 [revised]
PHST- 2023/03/20 00:00 [accepted]
PHST- 2023/04/14 06:41 [medline]
PHST- 2023/04/13 01:10 [entrez]
PHST- 2023/04/14 06:00 [pubmed]
PHST- 2023/03/24 00:00 [pmc-release]
AID - ijms24076126 [pii]
AID - ijms-24-06126 [pii]
AID - 10.3390/ijms24076126 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Mar 24;24(7):6126. doi: 10.3390/ijms24076126.