PMID- 37047294
OWN - NLM
STAT- MEDLINE
DCOM- 20230414
LR  - 20230415
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 7
DP  - 2023 Mar 28
TI  - IL-10 Promotes CXCL13 Expression in Macrophages Following Foot-and-Mouth Disease 
      Virus Infection.
LID - 10.3390/ijms24076322 [doi]
LID - 6322
AB  - Foot-and-mouth disease (FMD) is one of the most contagious livestock diseases in 
      the world, posing a constant global threat to the animal trade and national 
      economies. The chemokine C-X-C motif chemokine ligand 13 (CXCL13), a biomarker 
      for predicting disease progression in some diseases, was recently found to be 
      increased in sera from mice infected with FMD virus (FMDV) and to be associated 
      with the progression and severity of the disease. However, it has not yet been 
      determined which cells are involved in producing CXCL13 and the signaling 
      pathways controlling CXCL13 expression in these cells. In this study, the 
      expression of CXCL13 was found in macrophages and T cells from mice infected with 
      FMDV, and CXCL13 was produced in bone-marrow-derived macrophages (BMDMs) by 
      activating the nuclear factor-kappaB (NF-kappaB) and JAK/STAT pathways following FMDV 
      infection. Interestingly, CXCL13 concentration was decreased in sera from 
      interleukin-10 knock out (IL-10(-/-)) mice or mice blocked IL-10/IL-10R signaling 
      in vivo after FMDV infection. Furthermore, CXCL13 was also decreased in 
      IL-10(-/-) BMDMs and BMDMs treated with anti-IL-10R antibody following FMDV 
      infection in vitro. Lastly, it was demonstrated that IL-10 regulated CXCL13 
      expression via JAK/STAT rather than the NF-kappaB pathway. In conclusion, the study 
      demonstrated for the first time that macrophages and T cells were the cellular 
      sources of CXCL13 in mice infected with FMDV; CXCL13 was produced in BMDMs via 
      NF-kappaB and JAK/STAT pathways; and IL-10 promoted CXCL13 expression in BMDMs via 
      the JAK/STAT pathway.
FAU - Guo, Zijing
AU  - Guo Z
AUID- ORCID: 0000-0002-2291-700X
AD  - College of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, 
      Chengdu 610041, China.
FAU - Chen, Fei
AU  - Chen F
AD  - State Key Laboratory on Veterinary Etiological Biology, Lanzhou Veterinary 
      Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730030, 
      China.
FAU - Zhao, Shuaiyang
AU  - Zhao S
AD  - State Key Laboratory on Veterinary Etiological Biology, Lanzhou Veterinary 
      Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730030, 
      China.
FAU - Zhang, Zhixiong
AU  - Zhang Z
AD  - State Key Laboratory on Veterinary Etiological Biology, Lanzhou Veterinary 
      Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730030, 
      China.
FAU - Zhang, Huijun
AU  - Zhang H
AD  - State Key Laboratory on Veterinary Etiological Biology, Lanzhou Veterinary 
      Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730030, 
      China.
FAU - Bai, Ling
AU  - Bai L
AD  - State Key Laboratory on Veterinary Etiological Biology, Lanzhou Veterinary 
      Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730030, 
      China.
FAU - Zhang, Zhidong
AU  - Zhang Z
AUID- ORCID: 0000-0002-2186-7661
AD  - College of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, 
      Chengdu 610041, China.
FAU - Li, Yanmin
AU  - Li Y
AD  - College of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, 
      Chengdu 610041, China.
LA  - eng
GR  - 2021115/Southwest Minzu University Research Startup Funds/
GR  - 20YF3WA008/Gansu Province Science and Technology Planning Project/
GR  - 2016YFE0204100/National Key R & D Program of China/
PT  - Journal Article
DEP - 20230328
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (NF-kappa B)
RN  - 130068-27-8 (Interleukin-10)
RN  - EC 2.7.10.2 (Janus Kinases)
RN  - 0 (STAT Transcription Factors)
RN  - 0 (Cxcl13 protein, mouse)
RN  - 0 (Chemokine CXCL13)
SB  - IM
MH  - Mice
MH  - Animals
MH  - *Foot-and-Mouth Disease Virus
MH  - NF-kappa B/metabolism
MH  - Signal Transduction
MH  - Interleukin-10/metabolism
MH  - Janus Kinases/metabolism
MH  - STAT Transcription Factors/metabolism
MH  - Macrophages/metabolism
MH  - Chemokine CXCL13/metabolism
PMC - PMC10093876
OTO - NOTNLM
OT  - C-X-C motif chemokine ligand 13
OT  - foot-and-mouth disease virus
OT  - interleukin-10
OT  - macrophage
OT  - signaling pathways
COIS- The authors declare that the study was conducted in the absence of any commercial 
      or financial relationships that could be construed as a potential conflict of 
      interest.
EDAT- 2023/04/14 06:00
MHDA- 2023/04/14 06:42
PMCR- 2023/03/28
CRDT- 2023/04/13 01:11
PHST- 2023/01/17 00:00 [received]
PHST- 2023/03/13 00:00 [revised]
PHST- 2023/03/15 00:00 [accepted]
PHST- 2023/04/14 06:42 [medline]
PHST- 2023/04/13 01:11 [entrez]
PHST- 2023/04/14 06:00 [pubmed]
PHST- 2023/03/28 00:00 [pmc-release]
AID - ijms24076322 [pii]
AID - ijms-24-06322 [pii]
AID - 10.3390/ijms24076322 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Mar 28;24(7):6322. doi: 10.3390/ijms24076322.