PMID- 37047394
OWN - NLM
STAT- MEDLINE
DCOM- 20230414
LR  - 20230415
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 7
DP  - 2023 Mar 29
TI  - Post-Transcriptional Regulatory Crosstalk between MicroRNAs and Canonical 
      TGF-beta/BMP Signalling Cascades on Osteoblast Lineage: A Comprehensive Review.
LID - 10.3390/ijms24076423 [doi]
LID - 6423
AB  - MicroRNAs (miRNAs) are a family of small, single-stranded, and non-protein coding 
      RNAs about 19 to 22 nucleotides in length, that have been reported to have 
      important roles in the control of bone development. MiRNAs have a strong 
      influence on osteoblast differentiation through stages of lineage commitment and 
      maturation, as well as via controlling the activities of osteogenic signal 
      transduction pathways. Generally, miRNAs may modulate cell stemness, 
      proliferation, differentiation, and apoptosis by binding the 3'-untranslated 
      regions (3'-UTRs) of the target genes, which then can subsequently undergo 
      messenger RNA (mRNA) degradation or protein translational repression. MiRNAs 
      manage the gene expression in osteogenic differentiation by regulating multiple 
      signalling cascades and essential transcription factors, including the 
      transforming growth factor-beta (TGF-beta)/bone morphogenic protein (BMP), 
      Wingless/Int-1(Wnt)/beta-catenin, Notch, and Hedgehog signalling pathways; the 
      Runt-related transcription factor 2 (RUNX2); and osterix (Osx). This shows that 
      miRNAs are essential in regulating diverse osteoblast cell functions. TGF-betas and 
      BMPs transduce signals and exert diverse functions in osteoblastogenesis, 
      skeletal development and bone formation, bone homeostasis, and diseases. Herein, 
      we highlighted the current state of in vitro and in vivo research describing 
      miRNA regulation on the canonical TGF-beta/BMP signalling, their effects on 
      osteoblast linage, and understand their mechanism of action for the development 
      of possible therapeutics. In this review, particular attention and comprehensive 
      database searches are focused on related works published between the years 2000 
      to 2022, using the resources from PubMed, Google Scholar, Scopus, and Web of 
      Science.
FAU - Loh, Hui-Yi
AU  - Loh HY
AD  - Department of Cell and Molecular Biology, Faculty of Biotechnology and 
      Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, 
      Malaysia.
FAU - Norman, Brendan P
AU  - Norman BP
AD  - Department of Musculoskeletal and Ageing Science, Institute of Life Course and 
      Medical Sciences, University of Liverpool, Liverpool L7 8TX, UK.
FAU - Lai, Kok-Song
AU  - Lai KS
AD  - Health Sciences Division, Abu Dhabi Women's College, Higher Colleges of 
      Technology, Abu Dhabi 41012, United Arab Emirates.
FAU - Cheng, Wan-Hee
AU  - Cheng WH
AD  - Faculty of Health and Life Sciences, INTI International University, Persiaran 
      Perdana BBN, Putra Nilai, Nilai 71800, Negeri Sembilan, Malaysia.
FAU - Nik Abd Rahman, Nik Mohd Afizan
AU  - Nik Abd Rahman NMA
AUID- ORCID: 0000-0003-4835-4687
AD  - Department of Cell and Molecular Biology, Faculty of Biotechnology and 
      Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, 
      Malaysia.
FAU - Mohamed Alitheen, Noorjahan Banu
AU  - Mohamed Alitheen NB
AD  - Department of Cell and Molecular Biology, Faculty of Biotechnology and 
      Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, 
      Malaysia.
FAU - Osman, Mohd Azuraidi
AU  - Osman MA
AUID- ORCID: 0000-0003-3425-1775
AD  - Department of Cell and Molecular Biology, Faculty of Biotechnology and 
      Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, 
      Malaysia.
LA  - eng
GR  - FRGS/1/2019/STG05/UPM/02/9/Fundamental Research Grant Scheme (FRGS) from the 
      Ministry of Education Malaysia./
PT  - Journal Article
PT  - Review
DEP - 20230329
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (MicroRNAs)
RN  - 0 (Hedgehog Proteins)
RN  - 0 (Bone Morphogenetic Proteins)
SB  - IM
MH  - *Transforming Growth Factor beta/genetics/metabolism
MH  - *MicroRNAs/genetics/metabolism
MH  - Osteogenesis/genetics
MH  - Hedgehog Proteins/metabolism
MH  - Bone Morphogenetic Proteins/metabolism
MH  - Cell Differentiation/genetics
MH  - Signal Transduction
MH  - Osteoblasts/metabolism
PMC - PMC10094338
OTO - NOTNLM
OT  - BMPs
OT  - Smads
OT  - TGF-betas
OT  - bone
OT  - bone diseases
OT  - microRNAs (miRNAs)
OT  - osteoblast lineage
OT  - osteogenic differentiation
COIS- The authors declare no conflict of interest.
EDAT- 2023/04/14 06:00
MHDA- 2023/04/14 06:41
PMCR- 2023/03/29
CRDT- 2023/04/13 01:11
PHST- 2022/11/07 00:00 [received]
PHST- 2022/12/22 00:00 [revised]
PHST- 2022/12/22 00:00 [accepted]
PHST- 2023/04/14 06:41 [medline]
PHST- 2023/04/13 01:11 [entrez]
PHST- 2023/04/14 06:00 [pubmed]
PHST- 2023/03/29 00:00 [pmc-release]
AID - ijms24076423 [pii]
AID - ijms-24-06423 [pii]
AID - 10.3390/ijms24076423 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Mar 29;24(7):6423. doi: 10.3390/ijms24076423.