PMID- 37047445
OWN - NLM
STAT- MEDLINE
DCOM- 20230414
LR  - 20230415
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 7
DP  - 2023 Mar 30
TI  - Reduced High-Density Lipoprotein Cholesterol Is an Independent Determinant of 
      Altered Bone Quality in Women with Type 2 Diabetes.
LID - 10.3390/ijms24076474 [doi]
LID - 6474
AB  - Type 2 diabetes mellitus (T2DM) is associated with an increased fracture risk. 
      Our study aimed to explore differences in bone alterations between T2DM women and 
      controls and to assess clinical predictors of bone impairment in T2DM. For this 
      observational case control study, we recruited 126 T2DM female patients and 117 
      non-diabetic, age- and BMI-comparable women, who underwent clinical examination, 
      routine biochemistry and dual-energy X-ray absorptiometry (DXA) scans for bone 
      mineral density (BMD) and trabecular bone score (TBS) assessment-derived indexes. 
      These were correlated to metabolic parameters, such as glycemic control and lipid 
      profile, by bivariate analyses, and significant variables were entered in 
      multivariate adjusted models to detect independent determinants of altered bone 
      status in diabetes. The T2DM patients were less represented in the normal bone 
      category compared with controls (5% vs. 12%; p = 0.04); T2DM was associated with 
      low TBS (OR: 2.47, C.I. 95%: 1.19-5.16, p = 0.016) in a regression model adjusted 
      for age, menopausal status and BMI. In women with T2DM, TBS directly correlated 
      with plasma high-density lipoprotein cholesterol (HDL-c) (p = 0.029) and vitamin 
      D (p = 0.017) levels. An inverse association was observed with menopausal status 
      (p < 0.001), metabolic syndrome (p = 0.014), BMI (p = 0.005), and waist 
      circumference (p < 0.001). In the multivariate regression analysis, lower HDL-c 
      represented the main predictor of altered bone quality in T2DM, regardless of 
      age, menopausal status, BMI, waist circumference, statin treatment, physical 
      activity, and vitamin D (p = 0.029; R(2) = 0.47), which likely underlies common 
      pathways between metabolic disease and bone health in diabetes.
FAU - Dule, Sara
AU  - Dule S
AD  - Department of Experimental Medicine, Sapienza University, 00161 Rome, Italy.
FAU - Barchetta, Ilaria
AU  - Barchetta I
AUID- ORCID: 0000-0003-0530-8568
AD  - Department of Experimental Medicine, Sapienza University, 00161 Rome, Italy.
FAU - Cimini, Flavia Agata
AU  - Cimini FA
AD  - Department of Experimental Medicine, Sapienza University, 00161 Rome, Italy.
FAU - Passarella, Giulia
AU  - Passarella G
AD  - Department of Experimental Medicine, Sapienza University, 00161 Rome, Italy.
FAU - Dellanno, Arianna
AU  - Dellanno A
AD  - Department of Experimental Medicine, Sapienza University, 00161 Rome, Italy.
FAU - Filardi, Tiziana
AU  - Filardi T
AUID- ORCID: 0000-0001-5002-0753
AD  - Department of Experimental Medicine, Sapienza University, 00161 Rome, Italy.
FAU - Venditti, Vittorio
AU  - Venditti V
AUID- ORCID: 0000-0003-1707-2687
AD  - Department of Experimental Medicine, Sapienza University, 00161 Rome, Italy.
FAU - Bleve, Enrico
AU  - Bleve E
AUID- ORCID: 0000-0003-1659-6796
AD  - Department of Experimental Medicine, Sapienza University, 00161 Rome, Italy.
FAU - Bailetti, Diego
AU  - Bailetti D
AD  - Department of Clinical Medicine, Public Health, Life and Environmental Sciences 
      (MeSVA), University of L'Aquila, 67100 L'Aquila, Italy.
FAU - Romagnoli, Elisabetta
AU  - Romagnoli E
AD  - Department of Experimental Medicine, Sapienza University, 00161 Rome, Italy.
FAU - Morano, Susanna
AU  - Morano S
AUID- ORCID: 0000-0002-8156-9543
AD  - Department of Experimental Medicine, Sapienza University, 00161 Rome, Italy.
FAU - Baroni, Marco Giorgio
AU  - Baroni MG
AUID- ORCID: 0000-0002-3224-6078
AD  - Department of Clinical Medicine, Public Health, Life and Environmental Sciences 
      (MeSVA), University of L'Aquila, 67100 L'Aquila, Italy.
AD  - Neuroendocrinology and Metabolic Diseases, IRCCS Neuromed, 86077 Pozzilli, Italy.
FAU - Cavallo, Maria Gisella
AU  - Cavallo MG
AUID- ORCID: 0000-0001-6630-8049
AD  - Department of Experimental Medicine, Sapienza University, 00161 Rome, Italy.
LA  - eng
GR  - Avvio alla Ricerca 2022/Sapienza University of Rome/
PT  - Journal Article
PT  - Observational Study
DEP - 20230330
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Cholesterol, HDL)
RN  - 1406-16-2 (Vitamin D)
RN  - 0 (Cholestanes)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy
MH  - Case-Control Studies
MH  - Cholesterol, HDL
MH  - Bone Density
MH  - Cancellous Bone
MH  - Vitamin D/therapeutic use
MH  - *Cholestanes
MH  - Lumbar Vertebrae
PMC - PMC10095189
OTO - NOTNLM
OT  - fracture risk
OT  - insulin resistance
OT  - lipid metabolism
OT  - metabolic syndrome
OT  - osteopenia
OT  - osteoporosis
OT  - trabecular bone score
COIS- The authors declare no conflict of interest. The funder had no role in the design 
      of the study; in the collection, analyses, or interpretation of data; in the 
      writing of the manuscript; or in the decision to publish the results.
EDAT- 2023/04/14 06:00
MHDA- 2023/04/14 06:41
PMCR- 2023/03/30
CRDT- 2023/04/13 01:12
PHST- 2023/02/22 00:00 [received]
PHST- 2023/03/21 00:00 [revised]
PHST- 2023/03/28 00:00 [accepted]
PHST- 2023/04/14 06:41 [medline]
PHST- 2023/04/13 01:12 [entrez]
PHST- 2023/04/14 06:00 [pubmed]
PHST- 2023/03/30 00:00 [pmc-release]
AID - ijms24076474 [pii]
AID - ijms-24-06474 [pii]
AID - 10.3390/ijms24076474 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Mar 30;24(7):6474. doi: 10.3390/ijms24076474.