PMID- 37047905
OWN - NLM
STAT- MEDLINE
DCOM- 20230414
LR  - 20230426
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 20
IP  - 7
DP  - 2023 Mar 28
TI  - Predictors of Maternal Serum Concentrations for Selected Persistent Organic 
      Pollutants (POPs) in Pregnant Women and Associations with Birth Outcomes: A 
      Cross-Sectional Study from Southern Malawi.
LID - 10.3390/ijerph20075289 [doi]
LID - 5289
AB  - Population exposure to persistent organic pollutants (POPs) may result in 
      detrimental health effects, especially to pregnant women, developing foetuses and 
      young children. We are reporting the findings of a cross-sectional study of 605 
      mothers in their late pregnancy, recruited between August 2020 and July 2021 in 
      southern Malawi, and their offspring. The aim was to measure the concentrations 
      of selected POPs in their maternal serum and indicate associations with social 
      demographic characteristics and birth outcomes. A high level of education was the 
      main predictor of p,p'-DDE (p = 0.008), p,p'-DDT (p < 0.001), cis-NC (p = 0.014), 
      o,p'-DDT (p = 0.019) and o,p'-DDE (p = 0.019) concentrations in maternal serum. 
      Multiparity was negatively associated with o,p'-DDE (p = 0.021) concentrations. 
      Maternal age was also positively associated (p,p'-DDE (p = 0.013), o,p'-DDT (p = 
      0.017) and o,p'-DDE (p = 0.045) concentrations. Living in rural areas was 
      inversely associated with high maternal serum concentrations of p,p'-DDT (p < 
      0.001). Gestational age was positively associated with p,p'-DDE (p = 0.031), 
      p,p'-DDT (p = 0.010) and o,p'-DDT (p = 0.022) concentrations. Lastly, an inverse 
      association was observed between head circumference and t-NC (p = 0.044), 
      Oxychlordane (p = 0.01) and cis-NC (p = 0.048). These results highlight the need 
      to continue monitoring levels of POPs among vulnerable populations in the 
      southern hemisphere.
FAU - Mwapasa, Mphatso
AU  - Mwapasa M
AUID- ORCID: 0000-0001-8402-6133
AD  - Department of Public Health and Nursing, Norwegian University of Science and 
      Technology, 7491 Trondheim, Norway.
FAU - Huber, Sandra
AU  - Huber S
AUID- ORCID: 0000-0003-4745-8767
AD  - Department of Laboratory Medicine, University Hospital of North Norway, 9038 
      Tromso, Norway.
FAU - Chakhame, Bertha Magreta
AU  - Chakhame BM
AUID- ORCID: 0000-0003-4924-1385
AD  - Department of Public Health and Nursing, Norwegian University of Science and 
      Technology, 7491 Trondheim, Norway.
AD  - School of Maternal, Neonatal and Reproductive Health, Kamuzu University of Health 
      Sciences, Blantyre 312225, Malawi.
FAU - Maluwa, Alfred
AU  - Maluwa A
AD  - Directorate of Research and Outreach, Malawi University of Science and 
      Technology, Thyolo 310106, Malawi.
FAU - Odland, Maria Lisa
AU  - Odland ML
AUID- ORCID: 0000-0003-4340-7145
AD  - Department of Public Health and Nursing, Norwegian University of Science and 
      Technology, 7491 Trondheim, Norway.
AD  - Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre 312233, 
      Malawi.
AD  - Department of Obstetrics and Gynaecology, St. Olav's Hospital, 7030 Trondheim, 
      Norway.
AD  - Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool 
      L7 8TX, UK.
FAU - Ndhlovu, Victor
AU  - Ndhlovu V
AUID- ORCID: 0000-0003-1606-0959
AD  - School of Life Sciences and Health Professions, Kamuzu University of Health 
      Sciences, Blantyre 312225, Malawi.
FAU - Rollin, Halina
AU  - Rollin H
AUID- ORCID: 0000-0001-5247-6519
AD  - School of Health Systems and Public Health, Faculty of Health Sciences, 
      University of Pretoria, Pretoria 0002, South Africa.
FAU - Xu, Shanshan
AU  - Xu S
AD  - Centre for International Health, Department of Global Public Health and Primary 
      Care, University of Bergen, 5009 Bergen, Norway.
FAU - Odland, Jon Oyvind
AU  - Odland JO
AUID- ORCID: 0000-0002-2756-0732
AD  - Department of Public Health and Nursing, Norwegian University of Science and 
      Technology, 7491 Trondheim, Norway.
AD  - Directorate of Research and Outreach, Malawi University of Science and 
      Technology, Thyolo 310106, Malawi.
AD  - School of Health Systems and Public Health, Faculty of Health Sciences, 
      University of Pretoria, Pretoria 0002, South Africa.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230328
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - D4K93Z1TBH (o,p'-DDT)
RN  - CIW5S16655 (DDT)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 0 (Persistent Organic Pollutants)
RN  - DM084YLQ1L (2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Child
MH  - Humans
MH  - Female
MH  - Pregnancy
MH  - Child, Preschool
MH  - *DDT
MH  - Pregnant Women
MH  - Dichlorodiphenyl Dichloroethylene
MH  - Persistent Organic Pollutants
MH  - Cross-Sectional Studies
MH  - Malawi
MH  - Parturition
MH  - *Environmental Pollutants
MH  - Mothers
PMC - PMC10093902
OTO - NOTNLM
OT  - Southern Malawi
OT  - birth outcomes
OT  - persistent organic pollutants
COIS- The authors declare no conflict of interest. The funders had no role in study 
      design, data collection, analyses or interpretation of the data. They also had no 
      role in writing the manuscript or in the decision to publish the results.
EDAT- 2023/04/14 06:00
MHDA- 2023/04/14 06:41
PMCR- 2023/03/28
CRDT- 2023/04/13 01:15
PHST- 2023/02/17 00:00 [received]
PHST- 2023/03/18 00:00 [revised]
PHST- 2023/03/24 00:00 [accepted]
PHST- 2023/04/14 06:41 [medline]
PHST- 2023/04/13 01:15 [entrez]
PHST- 2023/04/14 06:00 [pubmed]
PHST- 2023/03/28 00:00 [pmc-release]
AID - ijerph20075289 [pii]
AID - ijerph-20-05289 [pii]
AID - 10.3390/ijerph20075289 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2023 Mar 28;20(7):5289. doi: 
      10.3390/ijerph20075289.