PMID- 37048692
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231102
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 12
IP  - 7
DP  - 2023 Mar 30
TI  - Intranasal Fentanyl for Acute Pain Management in Children, Adults and Elderly 
      Patients in the Prehospital Emergency Service and in the Emergency Department: A 
      Systematic Review.
LID - 10.3390/jcm12072609 [doi]
LID - 2609
AB  - This systematic review examined the efficacy and safety of intranasal fentanyl 
      (INF) for acute pain treatment in children, adults, and the elderly in 
      prehospital emergency services (PHES) and emergency departments (ED). 
      ClinicalTrials.gov, LILACS, PubMed, SCOPUS, EMBASE, Google Scholar and Cochrane 
      databases were consulted until 31 December 2022. A total of 23 studies were 
      included: 18 in children (1 PHES, 17 ED), 5 in adults (1 PHES, 4 ED) and 1 in 
      older people (1 PHES subgroup analysis). In children, INF was effective in both 
      settings and as effective as the comparator drugs, with no differences in adverse 
      events (AEs); one randomised controlled trial (RCT) showed that INF was more 
      effective than the comparator drugs. In adults, one study demonstrated the 
      efficacy of INF in the PHES setting, one study demonstrated the efficacy of INF 
      in the ED setting, two RCTs showed INF to be less effective than the comparator 
      drugs and one RCT showed INF to be as effective as the comparator, with no 
      difference in AEs reported. In older people, one study showed effective pain 
      relief and no AEs. In summary, INF appears to be effective and safe in children 
      and adults in PHES and ED. More high-quality studies are needed, especially in 
      PHES and older people.
FAU - Serra, Sossio
AU  - Serra S
AUID- ORCID: 0000-0002-9281-3601
AD  - Emergency Department, Maurizio Bufalini Hospital, 47521 Cesena, Italy.
FAU - Spampinato, Michele Domenico
AU  - Spampinato MD
AUID- ORCID: 0000-0002-2285-327X
AD  - Department of Translational Medicine and for Romagna, University of Ferrara, 
      44124 Ferrara, Italy.
FAU - Riccardi, Alessandro
AU  - Riccardi A
AUID- ORCID: 0000-0002-4936-1531
AD  - Pronto Soccorso Ospedale di Imperia, 18100 Imperia, Italy.
FAU - Guarino, Mario
AU  - Guarino M
AD  - UOC MEU Ospedale CTO- AORN dei Colli Napoli, 80131 Naples, Italy.
FAU - Pavasini, Rita
AU  - Pavasini R
AUID- ORCID: 0000-0002-1763-9711
AD  - UO Cardiologia, Azienda Ospedaliero Universitaria di Ferrara, 44124 Ferrara, 
      Italy.
FAU - Fabbri, Andrea
AU  - Fabbri A
AUID- ORCID: 0000-0002-9837-4638
AD  - Emergency Department, AUSL Romagna, Presidio Ospedaliero Morgagni-Pierantoni, 
      47121 Forli, Italy.
FAU - De Iaco, Fabio
AU  - De Iaco F
AD  - Struttura Complessa di Medicina di Emergenza Urgenza Ospedale Maria Vittoria, ASL 
      Citta di Torino, 10144 Torino, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230330
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC10095441
OTO - NOTNLM
OT  - emergency department
OT  - fentanyl
OT  - intranasal administration
OT  - pain
OT  - prehospital emergency service
COIS- The authors declare no conflict of interest.
EDAT- 2023/04/14 06:00
MHDA- 2023/04/14 06:01
PMCR- 2023/03/30
CRDT- 2023/04/13 01:19
PHST- 2023/02/22 00:00 [received]
PHST- 2023/03/22 00:00 [revised]
PHST- 2023/03/26 00:00 [accepted]
PHST- 2023/04/14 06:01 [medline]
PHST- 2023/04/13 01:19 [entrez]
PHST- 2023/04/14 06:00 [pubmed]
PHST- 2023/03/30 00:00 [pmc-release]
AID - jcm12072609 [pii]
AID - jcm-12-02609 [pii]
AID - 10.3390/jcm12072609 [doi]
PST - epublish
SO  - J Clin Med. 2023 Mar 30;12(7):2609. doi: 10.3390/jcm12072609.