PMID- 3705100
OWN - NLM
STAT- MEDLINE
DCOM- 19860602
LR  - 20190819
IS  - 0378-4274 (Print)
IS  - 0378-4274 (Linking)
VI  - 30
IP  - 2
DP  - 1986 Feb
TI  - Relationship between the neurotoxicities of Soman, Sarin and Tabun, and 
      acetylcholinesterase inhibition.
PG  - 121-9
AB  - Acetylcholinesterase (AChE)-induced chewing movements, tremors, convulsions and 
      hind limb abduction at doses of 50-85% LD50 in rats were monitored in order to 
      determine whether the severity of these different signs would correlate with 
      brain AChE levels and the time course of such a relationship. 30 min after 
      subcutaneous (s.c.) injection of Soman, the intensities of toxic signs were 
      significantly correlated with the degree of striatal AChE inhibition. In the case 
      of Sarin, the corresponding r-values were not significant except for tremors. For 
      Tabun-induced chewing, tremor and hind-limb abduction, the r-values were 
      significant. The neurotoxicity was most intense between 15 min to 2 h after 
      treatment, but at 2 or 6 h, the r-values were well below 0.5. The inhibition of 
      brain AChE was maximal by 30 min and was still high at 24 h.
FAU - Hoskins, B
AU  - Hoskins B
FAU - Fernando, J C
AU  - Fernando JC
FAU - Dulaney, M D
AU  - Dulaney MD
FAU - Lim, D K
AU  - Lim DK
FAU - Liu, D D
AU  - Liu DD
FAU - Watanabe, H K
AU  - Watanabe HK
FAU - Ho, I K
AU  - Ho IK
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Cholinesterase Inhibitors)
RN  - 0 (Organophosphates)
RN  - 0 (Organophosphorus Compounds)
RN  - 96-64-0 (Soman)
RN  - B4XG72QGFM (Sarin)
RN  - S45M750QSH (tabun)
SB  - IM
MH  - Animals
MH  - Cholinesterase Inhibitors/*toxicity
MH  - Corpus Striatum/drug effects/metabolism
MH  - Injections, Subcutaneous
MH  - Male
MH  - Mastication/drug effects
MH  - Organophosphates/*toxicity
MH  - Organophosphorus Compounds/*toxicity
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sarin/*toxicity
MH  - Seizures/chemically induced
MH  - Soman/*toxicity
MH  - Tremor/chemically induced
EDAT- 1986/02/01 00:00
MHDA- 1986/02/01 00:01
CRDT- 1986/02/01 00:00
PHST- 1986/02/01 00:00 [pubmed]
PHST- 1986/02/01 00:01 [medline]
PHST- 1986/02/01 00:00 [entrez]
AID - 0378-4274(86)90094-9 [pii]
AID - 10.1016/0378-4274(86)90094-9 [doi]
PST - ppublish
SO  - Toxicol Lett. 1986 Feb;30(2):121-9. doi: 10.1016/0378-4274(86)90094-9.