PMID- 37051543
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230415
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 13
DP  - 2023
TI  - Exploration of the methods of establishing the minimum clinical important 
      difference based on anchors and their applications in the quality of life 
      measurement scale QLICP-BR (V2.0) for breast cancer.
PG  - 1123258
LID - 10.3389/fonc.2023.1123258 [doi]
LID - 1123258
AB  - OBJECTIVE: The measurement of the quality of life (QOL) in patients with breast 
      cancer can evaluate the therapeutic effects of medical treatments and help to 
      provide reference for clinical decisions. The minimum clinically important 
      difference (MCID) can be better used in clinical interpretation than the 
      traditional statistical significance. Based on the anchors, a variety of ways 
      including traditional and updated anchor-based methods were used to explore most 
      suitable MCID, so that to find better interpretation on scores of the scale 
      QLICP-BR(V2.0) (Quality of Life Instruments for Cancer Patients-Breast cancer). 
      METHODS: According to the investigation data of breast cancer patients before and 
      after treatment, the most relevant indicators in various domains of QLICP-BR 
      (V2.0) was found as an anchor to statistically analyze the value of MCID, and 
      three analysis methods of anchors were used: Traditional anchor-based method, ROC 
      curve method, multiple linear regression model analysis. Anchors are divided into 
      four standards according to the degree of change in the treatment effect: one 
      grade difference (Standard A), at least one grade difference (Standard B), one 
      grade better (Standard C), better (Standard D). The final MCID value is selected 
      from different statistical methods and classification standards that are most 
      suitable for clinicians to use. RESULTS: Using Q29 of the EORTC QLQ-C30 as an 
      anchor has the highest correlation with each domain of QLICP. The order of 
      magnitude of MCID values among the four standard groups is: standard A< Standard 
      C< Standard B< Standard D. The MCID value obtained by the ROC curve method is the 
      most stable and is least affected by the sample size, and the MCID value obtained 
      by the multiple linear regression model is the least. After comparisons and 
      discussions, Standard C in the multiple linear regression model is used to 
      determine the final MCID, which is the closest to other methods. After integer 
      the MCID values of Physical domain (PHD), Psychological domain (PSD), Social 
      domain (SOD), Common symptoms and side effect domain (SSD), Core/general module 
      (CGD), Specific domain (SPD), Total score(TOT) can be taken as 15,10, 10, 11, 10, 
      9 and 9, respectively. CONCLUSION: In the evaluation of the QOL of breast cancer 
      patients, although the results of MCID values produced by different methods are 
      different, the results are relatively close. The anchor-based methods make the 
      results of MCID more clinically interpretable by introducing clinical variables, 
      and clinicians and researchers can choose the appropriate method according to the 
      research purpose.
CI  - Copyright (c) 2023 Zhou, Liu, Tan, Hu, Chen and Wan.
FAU - Zhou, Xuan
AU  - Zhou X
AD  - Key Laboratory for Quality of Life and Psychological assessment and Intervention, 
      School of Humanities and Management, Research Center for Quality of Life and 
      Applied Psychology, Guangdong Medical University, Dongguan, China.
FAU - Liu, Yuxi
AU  - Liu Y
AD  - Key Laboratory for Quality of Life and Psychological assessment and Intervention, 
      School of Humanities and Management, Research Center for Quality of Life and 
      Applied Psychology, Guangdong Medical University, Dongguan, China.
FAU - Tan, Jianfeng
AU  - Tan J
AD  - Key Laboratory for Quality of Life and Psychological assessment and Intervention, 
      School of Humanities and Management, Research Center for Quality of Life and 
      Applied Psychology, Guangdong Medical University, Dongguan, China.
FAU - Hu, Liren
AU  - Hu L
AD  - School of Public Health, Guangdong Medical University, Dongguan, China.
FAU - Chen, Huanwei
AU  - Chen H
AD  - Oncology Department, Central Hospital of Guangdong Nongken, Zhanjiang, China.
FAU - Wan, Chonghua
AU  - Wan C
AD  - Key Laboratory for Quality of Life and Psychological assessment and Intervention, 
      School of Humanities and Management, Research Center for Quality of Life and 
      Applied Psychology, Guangdong Medical University, Dongguan, China.
LA  - eng
PT  - Journal Article
DEP - 20230327
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC10083364
OTO - NOTNLM
OT  - QLICP-BR(V2.0)
OT  - ROC curve method
OT  - anchor-based methods
OT  - breast cancer
OT  - minimum clinically important difference
OT  - multiple linear regression model
OT  - quality of life
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/04/14 06:00
MHDA- 2023/04/14 06:01
PMCR- 2023/01/01
CRDT- 2023/04/13 02:04
PHST- 2022/12/13 00:00 [received]
PHST- 2023/03/14 00:00 [accepted]
PHST- 2023/04/14 06:01 [medline]
PHST- 2023/04/13 02:04 [entrez]
PHST- 2023/04/14 06:00 [pubmed]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2023.1123258 [doi]
PST - epublish
SO  - Front Oncol. 2023 Mar 27;13:1123258. doi: 10.3389/fonc.2023.1123258. eCollection 
      2023.