PMID- 37051904
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20231216
IS  - 1469-8978 (Electronic)
IS  - 0033-2917 (Linking)
VI  - 53
IP  - 15
DP  - 2023 Nov
TI  - Associations between aberrant working memory-related neural activity and 
      cognitive impairments in somatically healthy, remitted patients with mood 
      disorders.
PG  - 7203-7213
LID - 10.1017/S0033291723000715 [doi]
AB  - BACKGROUND: Persistent cognitive deficits are prevalent in patients with bipolar 
      disorder (BD) and unipolar disorder (UD), but treatments effectively targeting 
      cognition in these mood disorders are lacking. This is partly due to poor insight 
      into the neuronal underpinnings of cognitive deficits. METHODS: The aim of this 
      functional magnetic resonance imaging (fMRI) study was to investigate the 
      neuronal underpinnings of working memory (WM)-related deficits in somatically 
      healthy, remitted patients with BD or UD (n = 66) with cognitive and functional 
      impairments compared to 38 healthy controls (HC). The participants underwent 
      neuropsychological testing and fMRI, while performing a visuospatial and a verbal 
      N-back WM paradigm. RESULTS: Relative to HC, patients exhibited hypo-activity 
      across dorsolateral prefrontal cortex as well as frontal and parietal nodes of 
      the cognitive control network (CCN) and hyper-activity in left orbitofrontal 
      cortex within the default mode network (DMN) during both visuospatial and verbal 
      WM performance. Verbal WM-related response in the left posterior superior frontal 
      gyrus (SFG) within CCN was lower in patients and correlated positively with 
      out-of-scanner executive function performance across all participants. 
      CONCLUSIONS: Our findings suggest that cognitive impairments across BD and UD are 
      associated with insufficient recruitment of task-relevant regions in the CCN and 
      down-regulation of task-irrelevant orbitofrontal activity within the DMN during 
      task performance. Specifically, a lower recruitment of the left posterior SFG 
      within CCN during verbal WM was associated with lower cognitive performance.
FAU - Macoveanu, Julian
AU  - Macoveanu J
AUID- ORCID: 0000-0001-6148-9477
AD  - Neurocognition and Emotion in Affective Disorders (NEAD) Centre, Psychiatric 
      Centre Copenhagen, Mental Health Services, Capital Region of Denmark, and 
      Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
FAU - Petersen, Jeff Zarp
AU  - Petersen JZ
AUID- ORCID: 0000-0002-3415-8098
AD  - Neurocognition and Emotion in Affective Disorders (NEAD) Centre, Psychiatric 
      Centre Copenhagen, Mental Health Services, Capital Region of Denmark, and 
      Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
FAU - Fisher, Patrick M
AU  - Fisher PM
AUID- ORCID: 0000-0002-8115-0611
AD  - Neurobiology Research Unit and Center for Integrated Molecular Imaging, 
      Rigshospitalet, Copenhagen, Denmark.
FAU - Kessing, Lars Vedel
AU  - Kessing LV
AUID- ORCID: 0000-0001-9377-9436
AD  - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
AD  - Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre 
      Copenhagen, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
FAU - Knudsen, Gitte Moos
AU  - Knudsen GM
AUID- ORCID: 0000-0003-1508-6866
AD  - Neurobiology Research Unit and Center for Integrated Molecular Imaging, 
      Rigshospitalet, Copenhagen, Denmark.
AD  - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
FAU - Miskowiak, Kamilla Woznica
AU  - Miskowiak KW
AUID- ORCID: 0000-0003-2572-1384
AD  - Neurocognition and Emotion in Affective Disorders (NEAD) Centre, Psychiatric 
      Centre Copenhagen, Mental Health Services, Capital Region of Denmark, and 
      Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
AD  - Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre 
      Copenhagen, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
DEP - 20230413
PL  - England
TA  - Psychol Med
JT  - Psychological medicine
JID - 1254142
SB  - IM
MH  - Humans
MH  - Mood Disorders/complications
MH  - Memory, Short-Term/physiology
MH  - *Bipolar Disorder
MH  - *Cognitive Dysfunction
MH  - Executive Function
MH  - Memory Disorders/complications
MH  - Magnetic Resonance Imaging/methods
MH  - Neuropsychological Tests
OTO - NOTNLM
OT  - Bipolar disorder
OT  - cognitive impairment
OT  - depression
OT  - fMRI
EDAT- 2023/04/14 06:00
MHDA- 2023/12/17 09:42
CRDT- 2023/04/13 05:02
PHST- 2023/12/17 09:42 [medline]
PHST- 2023/04/14 06:00 [pubmed]
PHST- 2023/04/13 05:02 [entrez]
AID - S0033291723000715 [pii]
AID - 10.1017/S0033291723000715 [doi]
PST - ppublish
SO  - Psychol Med. 2023 Nov;53(15):7203-7213. doi: 10.1017/S0033291723000715. Epub 2023 
      Apr 13.